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Molecular Pharmacology, Vol 1, 202-204, Copyright © 1965 by the American Society for Pharmacology and Experimental Therapeutics

Reductive Activation and Inactivation of Mitomycin As Studied with Human and Bacterial Cell Cultures

WACLAW SZYBALSKI 1 and V. G. ARNESON 1

1 McArdle Laboratory, University of Wisconsin, Madison, Wisconsin

Sodium borohydride at noninhibitory concentrations (50 µg/ml) reverses almost completely the lethal effects of mitomycin C when added within 5 min (human cell cultures) or 10 sec (bacteria) after cell exposure to the antibiotic. Sodium cyanide, dinitrophenol, and phenethyl alcohol, shown previously to augment the bactericidal effects of mitomycin, have no influence on the lethal action of this antibiotic for human cells.

Note:
ACKNOWLEDGMENTS We are indebted to Dr. S. Wakaki (Kyowa Hakko Kogyo Co., Tokyo) for supplying us with mitomycin C, and to Dr. Elizabeth H. Szybalska for her editorial help. This study was supported by Grant CA-07175 from the National Cancer Institute.

Submitted on June 21, 1965






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