MolPharm

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by O’MALLEY, J. A.
Right arrow Articles by CARTER, W. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by O’MALLEY, J. A.
Right arrow Articles by CARTER, W. A.

Molecular Pharmacology, Vol 11, 61-69, Copyright © 1975 by the American Society for Pharmacology and Experimental Therapeutics

Antiviral Activity of Partially Thiolated Polynucleotides

J. A. O’MALLEY 1, Y. K. HO 1, P. CHAKRABARTI 1, L. DIBERARDINO 1, P. CHANDRA 1, D. A. O. ORINDA 1, D. M. BYRD 1, T. J. BARDOS 1, and W. A. CARTER 1

1 Departments of Medical Viral Oncology, Roswell Park Memorial Institute 14203, and Medicinal Chemistry, State University of New York at Buffalo, Buffalo, New York 14214, and University of Frankfurt Medical School, Frankfurt, Germany

Structural modification of poly(I)·poly(C) (thiolation of position 5 of some of the cytosine bases in polycytidylate) produces compounds which induce antiviral activity in both human and murine cells. Since increasing degrees of thiolation increase nuclease resistance, this study reaffirms the notion that enhanced nucleolytic resistance of double-stranded RNAs is not a critical property for interferon induction. Depletion of the full expression of the antiviral state in human cells occurred after washing the cells shortly after poly(I)·poly(C) exposure; addition of fresh poly(I)·poly(C) did not restore full antiviral function to the washed cells. However, prior treatment with thiolated complexes abolished this depletion. The thiolated polymers may prove to be useful in circumventing the hyporesponsiveness usually seen after repeated stimulation with the interferon inducer poly(I)·poly(C), in experimental viral infections.

Submitted on July 23, 1974




This article has been cited by other articles:


Home page
 Exp. Biol. Med.Home page
J. L. Ambrus Sr., K. C. Chadha, A. Islam, S. Akhter, and J. L. Ambrus Jr.
Treatment of Viral and Neoplastic Diseases with Double-Stranded RNA Derivatives and Other New Agents
Experimental Biology and Medicine, September 1, 2006; 231(8): 1283 - 1286.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1975 by the American Society for Pharmacology and Experimental Therapeutics