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Molecular Pharmacology, Vol 11, 87-93, Copyright © 1975 by the American Society for Pharmacology and Experimental Therapeutics

Biosynthesis of Biopterin by Two Clones of Mouse Neuroblastoma

KLAUS BUFF 1 and WALLACE DAIRMAN 1

1 Roche Institute of Molecular Biology, Nutley, New Jersey 07110

Mouse neuroblastoma clones N-18 and N-1E were found to incorporate radioactivity from [2-14C]guanosine into biopterin on its oxidation product, pterin-6-carboxylic acid. When similar incubations were carried out in the presence of [8-14C]guanosine little or no incorporation of radioactivity into the pterins occurred. These results indicate that the mammalian neuroblastoma cell line can synthesize biopterin from a purine precursor. The lack of incorporation of radioactivity into the pterins from [8-14C]guanosine indicates that the mammalian biosynthetic pathway may be similar to that found in bacteria.

Submitted on July 31, 1974






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