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Molecular Pharmacology, Vol 11, 232-235, Copyright © 1975 by the American Society for Pharmacology and Experimental Therapeutics

Evidence That Dopamine Is Not a Substrate for Adrenal Phenylethanolamine N-Methyltransferase

ROBERT G. PENDLETON 1 and GEORGE GESSNER 1

1 Smith Kline & French Laboratories, Philadelphia, Pennsylvania 19101

We found that dopamine is not a substrate for adrenal phenylethanolamine N-methyltransferase in vitro at concentrations from 1 µM to 10 mM, using both the bovine and the rabbit adrenal enzyme. In the adrenal glands of intact rats, [3H]dopamine was rapidly converted to [3H]norepinephrine and subsequently to [3H]epinephrine. No significant levels of [3H]epinine were detected.

Submitted on December 30, 1974






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