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Molecular Pharmacology, Vol 12, 185-190, Copyright © 1976 by the American Society for Pharmacology and Experimental Therapeutics

Interactions of the Antibiotic Distamycin A with Homopolymeric Single-Stranded Polydeoxyribonucleotides and with PHgrX 174 Deoxyribonucleic Acid

ANNE K. KREY 1, JOHN G. OLENICK 1, and FRED E. HAHN 1

1 Department of Molecular Biology, Walter Reed Army Institute of Research, Washington, D. C. 20012

The absorption spectrum of distamycin A was changed by poly dA, poly dT, poly dG, and poly dC and also by PHgrX 174 DNA. Poly dA and, to a lesser extent, poly dG induced a Cotton effect in the optical rotatory dispersion spectrum of distamycin A. The complex of distamycin A and PHgrX 174 DNA showed a reverisble cooperative transition upon heating and cooling. Distamycin A inhibited the template activities of poly dA and poly dT in an RNA polymerase reaction in vitro.

Submitted on June 6, 1975






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