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Molecular Pharmacology, Vol 12, 191-193, Copyright © 1976 by the American Society for Pharmacology and Experimental Therapeutics

Aurintricarboxylic Acid Is a Nonspecific Enzyme Inhibitor

MINOU BINA-STEIN 1 and THOMAS R. TRITTON 1

1 Department of Chemistry, Yale University, New Haven, Connecticut 06520

Aurintricarboxylic acid (ATA) has been previously categorized as a drug which inhibits enzymes of polynucleotide metabolism. In this paper we present evidence that ATA does not show specificity toward this class of enzymes only. Rather, the drug will bind to and inhibit most enzymes regardless of their specific catalytic function.

Note:
ACKNOWLEDGMENTS We thank Dr. R. E. Handschumacher for purified E. coli asparaginase, Dr. L. Lachman for teaching us the asparaginase assay method, and Dr. F. Kalousek for a gift of E. coli seryl-tRNA synthetase. We are also grateful to Dr. Alan Cooper for stimulating conversations, and to Dr. Julian Sturtevant and Dr. Donald Crothers for providing laboratory space.

Submitted on May 6, 1975




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Copyright © 1976 by the American Society for Pharmacology and Experimental Therapeutics