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Molecular Pharmacology, Vol 12, 504-513, Copyright © 1976 by the American Society for Pharmacology and Experimental Therapeutics

Characterization of an Endogenous Morphine-like Factor (Enkephalin) in Mammalian Brain

GAVRIL W. PASTERNAK 1, RABI SIMANTOV 1, and SOLOMON H. SNYDER 1

1 Departments of Pharmacology and Experimental Therapeutics and Psychiatry and the Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

Mammalian brain extracts contain a substance, "enkephalin," which competes for opiate receptor binding in a highly selective fashion. This material behaves in opiate receptor assays as an opiate agonist, with its effects enhanced by manganese and decreased by sodium. The regional distribution of enkephalin parallels that of the opiate receptor itself. Enkephalin activity is degraded by carboxypeptidases A and B and leucinaminopeptidase as well as by chymotrypsin, but is resistant to trypsin and neuraminidase. Thus enkephalin appears to be a peptide. Gel filtration experiments indicate a molecular weight of about 1000.

Submitted on September 12, 1975




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Copyright © 1976 by the American Society for Pharmacology and Experimental Therapeutics