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Molecular Pharmacology, Vol 13, 181-184, Copyright © 1977 by the American Society for Pharmacology and Experimental Therapeutics

Inhibition of Sodium- and Potassium-Dependent Adenosine Triphosphatase by Serotonin

SIXTO GARCÍA-CASTINEIRAS 1, JOHN I. WHITE 1, and EFRAÍN TORO-GOYCO 1

1 Department of Biochemistry and Nutrition, University of Puerto Rico School of Medicine, San Juan, Puerto Rico 00936, and Department of Physiology, University of Maryland Dental School, Baltimore, Maryland 21201

Serotonin was identified as the potent (Na+ + K+-ATPase inhibitor previously reported to be present in the coelenterate Palythoa caribaeorum. As the serotonin-creatinine sulfate complex (commercial preparations) its inhibitory potency is sharply reduced. Inhibition is fully restored on fractionation of the complex on cation-exchange resins.

Note:
ACKNOWLEDGMENTS We thank Professor J. del Castillo and Mr. F. McKenzie for their generous supply of E. electricus and P. caribaeorum.

Submitted on June 7, 1976
Accepted on August 25, 1976






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