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Molecular Pharmacology, Vol 13, 382-385, Copyright © 1977 by the American Society for Pharmacology and Experimental Therapeutics

Localization of Adenylate Cyclase in Adrenal Medulla

STEVEN P. WILSON 1 and NORMAN KIRSHNER 1

1 Department of Biochemistry, Duke University Medical Center, Durham, North Carolina 27710

The localization of adenylate cyclase in bovine adrenal medulla was explored using a continuous sucrose density gradient to separate the various subcellular components of this tissue. The results indicate that adenylate cyclase is not a component of chromaffin vesicle membranes as reported earlier by Zinder et al. [(1976) J. Biol. Chem., 251, 2179-2181]. Adenylate cyclase activity observed in chromaffin vesicle membrane fractions is most likely due to contamination by plasma membranes.

Note:
ACKNOWLEDGMENT The authors thank Mrs. Dorothy Kamin for performing the catecholamine determinations.

Submitted on August 30, 1976
Accepted on November 3, 1976






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