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Molecular Pharmacology, Vol 19, 345-348, Copyright © 1981 by the American Society for Pharmacology and Experimental Therapeutics

Toxin T446 from Ptychodiscus brevis (Formerly Gymnodinium breve) Enhances Activation of Voltage-Sensitive Sodium Channels by Veratridine

WILLIAM A. CATTERALL 1 and MARTIN RISK 1

1 Department of Pharmacology, University of Washington, Seattle, Washington 98195, and Division of Environmental Toxicology and Epidemiology, University of Texas Medical Branch, Galveston, Texas 77550

Ptychodiscus brevis toxin T446 markedly enhances persistent activation of voltage-sensitive sodium channels in neuroblastoma cells by veratridine. Half-maximal enhancement is observed at 50 ng of T446 per milliliter. At maximally effective concentrations, T446 has no effect on specific binding of 125I-labeled scorpion toxin and slightly enhances specific binding of [3H]saxitoxin. Thus, T446 enhances veratridine action but does not bind to any of the three neurotoxin receptor sites on the sodium channels that have been previously described. T446 may act at a new toxin-receptor site associated with voltage-sensitive sodium channels.

Note:
ACKNOWLEDGMENTS We thank Ms. Cynthia S. Morrow and Ms. Sherryann C. Pesheck for excellent technical assistance.

Submitted on August 25, 1980
Accepted on November 4, 1980




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