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Molecular Pharmacology, Vol 2, 89-92, Copyright © 1966 by the American Society for Pharmacology and Experimental Therapeutics

Enhancement of 5-Iododeoxyuridine Incorporation into DNA of Cat Tissues in Vivo by Inhibition of Uridine-Deoxyuridine Phosphorylase

P. LANGEN 1 and G. ETZOLD 1

1 Institute of Biochemistry, German Academy of Sciences, Berlin, Berlin-Buch, Germany (G.D.R.)

When 131I-iododeoxyuridine (IUdR) (31 µmoles/kg) was given to cats, the in vivo incorporation into DNA of bone marrow, intestine, and spleen was increased 3- to 7-fold by deoxyglucosylthymine (TdG) given at a ratio IUdR:TdG = 1:2, and 5- to 14-fold at a ratio 1:5.

Submitted on October 20, 1965







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