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Molecular Pharmacology, Vol 2, 92-94, Copyright © 1966 by the American Society for Pharmacology and Experimental Therapeutics

Alanine Racemase from Staphylococcus aureus: Conformation of Its Substrates and Its Inhibitor, D-Cycloserine

ULDIS ROZE 1 and JACK L. STROMINGER 1

1 Department of Pharmacology, University of Wisconsin, Medical School, Madison, Wisconsin

D-Cycloserine is a competitive inhibitor of alanine racemase for which its Ki is 100 times smaller than the Km for either of the substrates, D- and L-alanine. L-Cycloserine, however, does not inhibit this enzyme. A hypothesis is proposed, based on molecular models, that D-cycloserine has the conformation required of the substrates on the enzyme surface. L-Cycloserine cannot have this conformation.

Submitted on October 4, 1965






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Copyright © 1966 by the American Society for Pharmacology and Experimental Therapeutics