![[Feedback]](/icons/banner/feedbackACT.gif){kind=icon}
![[For Subscribers]](/icons/banner/subscriberACT.gif){kind=icon}
![[Archive]](/icons/banner/archiveACT.gif){kind=icon}
![[Search]](/icons/banner/searchACT.gif){kind=icon}
![[Contents]](/icons/banner/tocACT.gif){kind=icon}
|
|
|
|
|
||
Molecular Pharmacology, Vol 2, 187-190, Copyright © 1966 by the American Society for Pharmacology and Experimental Therapeutics
1 Johnson Research Foundation, University of Pennsylvania, Philadelphia, Pennsylvania
2 Laboratory of Chemical Pharmacology, National Institutes of Health, Bethesda, Maryland
3 Harrison Department of Surgical Research, University of Pennsylvania
The addition to liver microsomes of various substrates, such as hexobarbital, aminopyrine, or aniline, causes two types of spectral changes. Spectrophotometric studies suggest that these changes are related to substrate interaction with a microsomal hemoprotein. On the basis of these observations, two hypotheses are suggested to explain the interaction of substrates with the liver microsomal mixed function oxidase system.
Note:
This work was supported in part by a grant
from the National Science Foundation (GB 2451)
and grants (AM 07217, AM 04484, and GM 12202)
of the U. S. Public Health Service. The studies
were carried out during tenures of U.S.P.H.S.
Research Career Development Awards HE 25132
to D. Y. Cooper and GM-K3-4111 to R. W.
Estabrook.
This article has been cited by other articles:
|
|
 |
|
  P. J. Murphy The Development of Drug Metabolism Research as Expressed in the Publications of ASPET: Part 2, 1959-1983 Drug Metab. Dispos., June 1, 2008; 36(6): 981 - 985. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. K. M. Miller, J. Cai, S. L. Ripp, W. M. Pierce Jr., T. H. Rushmore, and R. A. Prough STEREO- AND REGIOSELECTIVITY ACCOUNT FOR THE DIVERSITY OF DEHYDROEPIANDROSTERONE (DHEA) METABOLITES PRODUCED BY LIVER MICROSOMAL CYTOCHROMES P450 Drug Metab. Dispos., March 1, 2004; 32(3): 305 - 313. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Zhong, X. Li, S. Yamashina, M. von Frankenberg, N. Enomoto, K. Ikejima, M. Kolinsky, J. A. Raleigh, and R. G. Thurman Cyclosporin A Causes a Hypermetabolic State and Hypoxia in the Liver: Prevention by Dietary Glycine J. Pharmacol. Exp. Ther., December 1, 2001; 299(3): 858 - 865. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Qu, L. M. Graves, and R. G. Thurman PGE2 stimulates O2 uptake in hepatic parenchymal cells: involvement of the cAMP-dependent protein kinase Am J Physiol Gastrointest Liver Physiol, November 1, 1999; 277(5): G1048 - G1054. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Zhong, H. Connor, R. F. Stachlewitz, M. v. Frankenberg, R. P. Mason, J. J. Lemasters, and R. G. Thurman Role of Free Radicals in Primary Nonfunction of Marginal Fatty Grafts from Rats Treated Acutely with Ethanol Mol. Pharmacol., November 1, 1997; 52(5): 912 - 919. [Abstract] [Full Text]
|
|
|
|
 |
|
 D. W. Shoeman, J. G. White, and G. J. Mannering Cytochrome P-420: Tubular Aggregates from Hepatic Microsomes Science, September 26, 1969; 165(3900): 1371 - 1372. [Abstract] [PDF]
|
|
|
|
|
|
C. J. Sih Enzymatic Mechanism of Steroid Hydroxylation Science, March 21, 1969; 163(3873): 1297 - 1300. [PDF]
|
|
 |
 |
 |
|
 |
 |
 |
