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Molecular Pharmacology, Vol 2, 491-495, Copyright © 1966 by the American Society for Pharmacology and Experimental Therapeutics

Factors Influencing the Metabolism and Distribution of Corticosterone-1,2-3H in the Rat

R. P. MAICKEL 1, M. T. BUSH 1, W. R. JONDORF 1, F. P. MILLER 1, and J. R. GILLETTE 1

1 Laboratory of Chemical Pharmacology, National Heart Institute, Bethesda, Maryland 20014

The metabolism and distribution of intravenously administered tracer doses of corticosterone-1,2-3H are not affected by elevated plasma levels of endogenous corticosterone due to cold stress. Pretreatment with methylcholanthrene increased the plasma half-life of the labeled steroid, reflecting a decreased rate of metabolic destruction, but had no effect on the apparent volume of distribution. Pretreatment with phenylbutazone caused an increased volume of distribution with no change in the plasma half-life.

Submitted on May 18, 1966






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