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Molecular Pharmacology, Vol 2, 543-557, Copyright © 1966 by the American Society for Pharmacology and Experimental Therapeutics

Synthesis of Ribonucleic Acid in L Cells during Inhibition of Protein Synthesis by Cycloheximide

HERBERT L. ENNIS 1

1 Laboratory of Microbiol Genetics and Physiology St. Jude Children’s Research Hospital, and University of Tennessee Medical Units, Memphis, Tennessee 38101

The role of protein synthesis in ribonucleic acid (RNA) synthesis was studied using the antibiotic cycloheximide to dissociate the synthesis of these macromolecules in L cells growing in suspension culture. The experimental evidence indicated that uninterrupted synthesis of protein was required for normal ribosomal RNA formation and for normal transport of RNA from nucleus to cytoplasm.

Note:
ACKNOWLEDGMENTS I wish to thank Dr. A. E. Osterberg, National Cancer Institute, Bethesda, Maryland, for the gift of actinomycin D, and Mrs. R. Tirey for her excellent technical assistance. This investigation was supported by Public Health Service Grant GM 12359-02 from the Division of General Medical Sciences, by Grant GB 3521 from the National Science Foundation, and by the American Lebanese Syrian Associated Charities (ALSAC).

Submitted on July 8, 1966




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