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Molecular Pharmacology, Vol 2, 608-610, Copyright © 1966 by the American Society for Pharmacology and Experimental Therapeutics

Formation of a Dead Code Triplet through Replacement of the Terminal Ribonucleoside in Guanylyl-Uridylyl-Uridine and Guanylyl-Uridylyl-Cytidine by 6-Azacytidine

J. ScaronKODA 1, V. LISYacute 1, J. SMRT 1, A. HOLYacute 1, and F. ScaronORM 1

1 Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, Prague, Czechoslovakia

The binding of valyl-tRNA to ribosomes in vitro, stimulated by guanylyl-uridylyluridine and guanylyl-uridylyl-cytidine is not effected by guanylyl-uridylyl-6-azacytidine. This finding indicates the high chemical specificity of the pyrimidine components of the codon.

Note:
We express our thanks to the workers of the Isotope Laboratory of this Institute for radioactivity counts.

Submitted on September 30, 1966






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