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Molecular Pharmacology, Vol 2, 610-613, Copyright © 1966 by the American Society for Pharmacology and Experimental Therapeutics

Increased Synthesis of Norepinephrine in the Rat Heart on Electrical Stimulation of the Stellate Ganglia

ROBERT GORDON 1, JOHN V. O. REID 1, ALBERT SJOERDSMA 1, and SIDNEY UDENFRIEND 1

1 Laboratory of Clinical Biochemistry and Experimental Therapeutics Branch, National Heart Institute, National Institutes of Health, Bethesda, Maryland 20014

Electrical stimulation of the stellate ganglia results in increased formation of radioactive norepinephrine (NE) in the rat heart from L-tyrosine-14C but not from L-dopa-3H. These findings represent additional evidence that the activity of tyrosine hydroxylase, the rate-limiting step in NE synthesis, is increased by sympathetic nerve activity.

Submitted on September 23, 1966
Revised on October 6, 1966






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