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Molecular Pharmacology, Vol 20, 224-226, Copyright © 1981 by the American Society for Pharmacology and Experimental Therapeutics

The Effect of Alprenolol on the Beta-Receptor and Adenylate Cyclase Activity in Rabbit Heart Membranes

V. A. TKACHUK 1 and M. WOLLEMANN 1

1 Department of Biochemistry, Moscow State University, Moscow, Union of Soviet Socialist Republics, and Institute of Biochemistry, Biological Research Center, Hungarian Academy of Sciences, Szeged, Hungary

Incubation of rabbit heart membranes at 37° with 10-5 M alprenolol significantly increased the number of beta-receptor binding sites but did not change the adenylate cyclase activity. In the presence of guanine nucleotides, the effect of alprenolol incubation on the beta-receptor was enhanced. When the incubation was carried out at 4°, the alprenolol effect was lost.

Submitted on December 5, 1980
Accepted on February 24, 1981






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