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Molecular Pharmacology, Vol 20, 579-584, Copyright © 1981 by the American Society for Pharmacology and Experimental Therapeutics

The Binding of s-Triazine Metabolites to Rodent Hemoglobins Appears Irrelevant to Other Species

H. HAMBOECK 1, R. W. FISCHER 1, E. E. DI IORIO 1, and K. H. WINTERHALTER 1

1 Agricultural Division, Ciba-Geigy Ltd., 4002 Basel, and Laboratorium fuer Biochemie I, Eidgenoessische Technische Hochschule, 8092 Zurich, Switzerland

A sulfoxide metabolite of s-triazines binds to Cys beta-125 of rat hemoglobin rather than to the usually more reactive Cys beta-93, which is present in most mammalian hemoglobins. Hemoglobins from species other than rodents and chicken (Cys beta3-126) do not react with the sulfoxide. An attempt to explain this unexpected finding on a stereochemical basis is presented and the general implications of this phenomenon are discussed.

Submitted on January 19, 1981
Accepted on June 29, 1981






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