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Molecular Pharmacology, Vol 20, 592-597, Copyright © 1981 by the American Society for Pharmacology and Experimental Therapeutics

Dopamine- and Serotonin-Sensitive Adenylate Cyclase in the Gill of Aplysia californica

SAM WEISS 1 and GEORGE I. DRUMMOND 1

1 University Biochemistry Group, Division of Biochemistry, Department of Chemistry, University of Calgary, Calgary T2N 1N4 Canada

Stimulation of adenylate cyclase by dopamine and serotonin was examined in a particulate fraction of Aplysia gill homogenates. Dopamine augmented activity 3- to 5-fold (EC50, 10 µM), whereas serotonin increased activity 15- to 20-fold (EC50, 1 µM). Lysergic acid diethylamide and several ergot alkaloids were full or partial agonists for enzyme stimulation. Structure-activity relationships of dopaminergic and serotonergic stimulation and the blocking action of several antagonists suggest that structural similarities exist between the receptors that mediate dopamine and serotonin stimulation of adenylate cyclase.

Note:
ACKNOWLEDGMENTS The authors thank Dr. Ken Lukowiak and his graduate students, Jeff I. Goldberg and Peter C. Ruben, for providing gill tissue samples and for many thoughtful suggestions throughout the course of the study.

Submitted on May 7, 1981
Accepted on July 27, 1981




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