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2-Fluoroestradiol. Separation of estrogenicity from carcinogenicity

JG Liehr

Estrogenic and carcinogenic activity are shown to be separable properties. 2-Fluoroestradiol, a modified estrogen, did not induce renal clear-cell carcinoma in male Syrian hamsters despite its estrogenic potency, which is comparable to that of estradiol. 4- Fluoroestradiol, also a potent estrogen, did induce renal clear-cell carcinoma in this animal model, but more slowly than estradiol. 2,4- Dideuterioestradiol was found to be as estrogenic and also as carcinogenic as estradiol itself.

Volume 23, Issue 2, pp. 278-281, 03/01/1983
Copyright © 1983 by American Society for Pharmacology and Experimental Therapeutics




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Copyright © 1983 by the American Society for Pharmacology and Experimental Therapeutics