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In vitro translation of messenger RNA following exposure of human colon carcinoma cells in culture to 5-fluorouracil and 5-fluorouridine

RI Glazer and KD Hartman

Total mRNA from human colon carcinoma cell line HT-29 treated with either 5-fluorouracil or 5-fluorouridine was assessed in vitro in a reticulocyte lysate translation system. Under conditions of known drug- induced cell lethality, fluoropyrimidine-modified mRNA did not show major quantitative or qualitative changes in translational activity. These results suggest that drug-modified mRNA is probably not associated with the cytotoxicity manifested by these drugs.

Volume 23, Issue 2, pp. 540-546, 03/01/1983
Copyright © 1983 by American Society for Pharmacology and Experimental Therapeutics






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Molecular Interventions Drug Metabolism and Disposition

Copyright © 1983 by the American Society for Pharmacology and Experimental Therapeutics