MolPharm

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jung, G.
Right arrow Articles by Bessler, W. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jung, G.
Right arrow Articles by Bessler, W. G.

Interaction of metal-complexing compounds with lymphocytes and lymphoid cell lines

G Jung, G Hennings, M Pfeifer and WG Bessler

A variety of metal-complexing flavonoids (beta-hydroxyethyl rutoside, catechin, naringin, taxifolin, and quercetin) as well as several compounds which form mainly iron complexes (bathophenathroline, bathophenanthrolinebisulfonic acid, desferri-ferrioxamine B, ethylenediamine-di-o-hydroxyphenylacetic acid) were tested for their effects on mitogen-free and mitogen-activated mouse splenocyte cell cultures and on two human cell lines (Daudi, Bristol-8). The compounds strongly inhibited the incorporation of [3H]thymidine into DNA at agent concentrations ranging from 10 to 500 microM. On the other hand, at subinhibitory concentrations, slightly enhancing or synergistic effects were observed. We conclude that immune cell behavior can be bidirectionally influenced by the presence of metal-complexing agents, depending on their concentration in the medium.

Volume 23, Issue 3, pp. 698-702, 05/01/1983
Copyright © 1983 by American Society for Pharmacology and Experimental Therapeutics




This article has been cited by other articles:


Home page
 Pharmacol. Rev.Home page
E. Middleton Jr., C. Kandaswami, and T. C. Theoharides
The Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and Cancer
Pharmacol. Rev., December 1, 2000; 52(4): 673 - 751.
[Abstract] [Full Text] [PDF]

Home page
 Hum Exp ToxicolHome page
E. J Calabrese and L. A Baldwin
A general classification of U-shaped dose-response relationships in toxicology and their mechanistic foundations
Human and Experimental Toxicology, July 1, 1998; 17(7): 353 - 364.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
P. B. Gordon, I. Holen, and P. O. Seglen
Protection by Naringin and Some Other Flavonoids of Hepatocytic Autophagy and Endocytosis against Inhibition by Okadaic Acid
J. Biol. Chem., March 17, 1995; 270(11): 5830 - 5838.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1983 by the American Society for Pharmacology and Experimental Therapeutics