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Molecular size of the canine and human brain D2 dopamine receptor as determined by radiation inactivation

L Lilly, CM Fraser, CY Jung, P Seeman and JC Venter

Target-size analysis (radiation inactivation) has been utilized for determination of the molecular size of the striatal D2 dopamine receptor of both canine and human membranes. The dog and human receptors were found to have a molecular size of 123,000 daltons. The identity of molecular size values is consistent with available pharmacological and biochemical evidence supporting D2 dopamine receptor identity in canine and human tissues. These data suggest that the canine receptor may be a valid model for molecular and structural investigation of the human D2 dopamine receptor.

Volume 24, Issue 1, pp. 10-14, 07/01/1983
Copyright © 1983 by American Society for Pharmacology and Experimental Therapeutics






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All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1983 by the American Society for Pharmacology and Experimental Therapeutics