MolPharm

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Garel, M. C.
Right arrow Articles by Beuzard, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Garel, M. C.
Right arrow Articles by Beuzard, Y.

Inhibition of erythrocyte sickling by thiol reagents

MC Garel, C Domenget, F Galacteros, J Martin-Caburi and Y Beuzard

The antisickling effects of eight thiol reagents that cross the red cell membrane and then react with the cysteine beta 93, the only accessible thiol group of hemoglobin, have been investigated at various pO2 values. In spite of completely reacted hemoglobins, the potent antisickling effect varied from one compound to the other and was partially related to the extent of the increased oxygen affinity of intact sickle cells induced by these compounds. The formation of methemoglobin upon the incubation of red blood cells with some disulfides had only a small effect on the sickling process.

Volume 26, Issue 3, pp. 559-565, 11/01/1984
Copyright © 1984 by American Society for Pharmacology and Experimental Therapeutics




This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
M. T. Gladwin, X. Wang, C. D. Reiter, B. K. Yang, E. X. Vivas, C. Bonaventura, and A. N. Schechter
S-Nitrosohemoglobin Is Unstable in the Reductive Erythrocyte Environment and Lacks O2/NO-linked Allosteric Function
J. Biol. Chem., July 26, 2002; 277(31): 27818 - 27828.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. T. GLADWIN, A. N. SCHECHTER, J. H. SHELHAMER, and F. P. OGNIBENE
The Acute Chest Syndrome in Sickle Cell Disease . Possible Role of Nitric Oxide in Its Pathophysiology and Treatment
Am. J. Respir. Crit. Care Med., May 1, 1999; 159(5): 1368 - 1376.
[Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1984 by the American Society for Pharmacology and Experimental Therapeutics