MolPharm

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by KIRSHNER, N.
Right arrow Articles by SMITH, W. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by KIRSHNER, N.
Right arrow Articles by SMITH, W. J.

Molecular Pharmacology, Vol 3, 254-265, Copyright © 1967 by the American Society for Pharmacology and Experimental Therapeutics

Mechanism of Secretion from the Adrenal Medulla

II. Release of Catecholamines and Storage Vesicle Protein in Response to Chemical Stimulation

N. KIRSHNER 1, H. J. SAGE 1, and W. J. SMITH 1

1 Departments of Biochemistry and Pathology Duke University Medical Center, Durham, North Carolina 27706

The release of catecholamines and a specific protein of the storage vesicles was measured in isolated perfused bovine adrenal glands. Stimulation of catecholamine secretion by acetylcholine, nicotine, or Ba++ caused a parallel increase in the secretion of the storage vesicle protein. The ratio of catecholamines: vesicle protein in the perfusates was, within the limits of experimental error, the same as that in the intact gland. The release of both the vesicle protein and the catecholamines required Ca++ and was temperature dependent. These studies provide additional evidence to support the hypothesis that catecholamines are secreted from the medulla by a process in which the storage vesicle contents are released directly to the exterior of the cell.

Note:
ACKNOWLEDGMENT This work was supported by grants AM-0542 and AI-06710 from the National Institutes of Health.

Submitted on December 19, 1966






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1967 by the American Society for Pharmacology and Experimental Therapeutics