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Molecular Pharmacology, Vol 3, 396-398, Copyright © 1967 by the American Society for Pharmacology and Experimental Therapeutics

The Effect of Reduced and Oxidized Pteridine on Dopamine-beta-Hydroxylase Activity

MENEK GOLDSTEIN 1 and TONG HYUB JOH 1

1 New York University School of Medicine, Department of Psychiatry and Neurology, Neurochemistry Laboratory, New York, New York 10016

Tetrahydropteridine (DMPH4) reacts with dopamine-beta-hydroxylase anaerobically and forms a reduced enzyme intermediate which aerobically catalyzes the beta-hydroxylation of tyramine-3H. Under aerobic conditions DMPH4, in combination with NADH, is effective in the stimulation of enzymic beta-hydroxylation. Oxidized DMPH4 inhibits the enzymic activity.

Submitted on March 9, 1967






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