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Molecular Pharmacology, Vol 3, 399-400, Copyright © 1967 by the American Society for Pharmacology and Experimental Therapeutics

A Nuclear Magnetic Resonance Study of Hapten-Antibody Interaction

SEYMOUR JOFFE 1

1 The Saul R. Korey Department of Neurology and the Department of Biochemistry, Albert Einstein College of Medicine, New York, New York 10061

In the presence of purified specific antigalactosyl antibody, the hapten p-nitrophenyl-beta-D-galactoside showed changes in its nuclear magnetic resonance (NMR) spectrum for those protons attached to the aromatic ring. These changes were interpreted as line broadening and thus indicated the most energetic site of attachment of the hapten to the antibody.

Note:
This work was supported by U.S.P.H.S. Research Grants Nos. NB 03356-04 and NB 5114-08.

Submitted on April 3, 1967






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