MolPharm

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by SCHENKMAN, J. B.
Right arrow Articles by ESTABROOK, R. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by SCHENKMAN, J. B.
Right arrow Articles by ESTABROOK, R. W.

Molecular Pharmacology, Vol 3, 516-525, Copyright © 1967 by the American Society for Pharmacology and Experimental Therapeutics

Sex Differences in Drug Metabolism by Rat Liver Microsomes

JOHN B. SCHENKMAN 1, INGEBORG FREY 1, HERBERT REMMER 1, and RONALD W. ESTABROOK 1

1 Department of Biophysics and Physical Biochemistry, Johnson Research Foundation, University of Pennsylvania, Philadelphia 19104 and Institut für Toxikologie, Universität Tübingen, Tübingen, Germany

Sex differences in drug oxidase activity of liver microsomes from rats have been shown to be related to a difference in substrate affinity for the mixed function oxidase reaction, and not to a difference in the content of cytochrome P-450. These results, as well as spectral studies of substrate interaction with microsomal cytochrome, showed that microsomes isolated from livers of male rats had over twice the magnitude of substrate (hexobarbital and aminopyrine) binding than did microsomes isolated from the livers of female rats. Similar studies with aniline indicated only a small difference in Vmax or substrate induced spectral change between microsomes isolated from livers of male or female rats.

Note:
ACKNOWLEDGMENTS This work was supported in part by a grant from the National Science Foundation (GB 2451) and grants from the U.S. Public Health Service (GM 12202-02 and GM 27706), and by the Deutsche Forschungsgemeinschaft.

Submitted on May 17, 1967




This article has been cited by other articles:


Home page
 CarcinogenesisHome page
M. B. Schabath, M. R. Spitz, X. Zhang, G. L. Delclos, and X. Wu
Genetic variants of myeloperoxidase and lung cancer risk
Carcinogenesis, June 1, 2000; 21(6): 1163 - 1166.
[Abstract] [Full Text] [PDF]


Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1967 by the American Society for Pharmacology and Experimental Therapeutics