Molecular Pharmacology, Vol 3, 581-585, Copyright © 1967 by the American Society for Pharmacology and Experimental Therapeutics

The Interaction of Local Anesthetics with Lecithin Monolayers

¹ Department of Physiology, University of Chicago, Chicago, Illinois

The pressure-area curves were determined for synthetic L--(dipalmitoyl) lecithin monolayers on subsolutions containing the minimum blocking concentrations of the local anesthetics -naphthol thymol, ephedrine, procaine, tetracaine, phenyltoloxamine, quinine, and dibucaine. It is shown that there is an approximately linear relationship between the log of the rate of change of the surface pressure with concentration of these anesthetics and the product of the mole refraction and ionization potential. This correlation is related to a partition function based upon the London interaction energy.

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ACKNOWLEDGMENTS This research was supported by grants to Dr. Daniel P. Agin from the U.S. Public Health Service and from the Dr. Wallace C. and Clara A. Abbott Memorial Fund of the University of Chicago.