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Computer-automated structure evaluation of antileukemic 9- anilinoacridines

G Klopman and OT Macina

The computer-automated structure evaluation (CASE) program has been applied to the evaluation of antileukemic (L1210) and toxic activities of an extensive series of 9-anilinoacridines. Major molecular fragments relevant to the respective biological endpoints were automatically generated and incorporated within equations used to estimate the degree of activity. Correlations of these activating/inactivating fragments with the biological activities are discussed.

Volume 31, Issue 4, pp. 457-476, 04/01/1987
Copyright © 1987 by American Society for Pharmacology and Experimental Therapeutics






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All ASPET Journals Molecular Pharmacology Pharmacological Reviews
Molecular Interventions Drug Metabolism and Disposition

Copyright © 1987 by the American Society for Pharmacology and Experimental Therapeutics