Mol Pharm -- Table of Contents (52 [2])

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August 1997; 52 (2)   [Index by Author] [Cover Caption]

       Accelerated Communication

       Articles

       Errata

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Accelerated Communication:

Val J. Watts and Kim A. Neve: Activation of Type II Adenylate Cyclase by D₂ and D₄ but Not D₃ Dopamine Receptors
Mol Pharmacol 1997 52: 181-186. [Abstract] [Full Text] [PDF]

Articles:

Hakan Gürdal, Richard A. Bond, Mark D. Johnson, Eitan Friedman, and H. Ongun Onaran: An Efficacy-Dependent Effect of Cardiac Overexpression of $beta$ ₂-Adrenoceptor on Ligand Affinity in Transgenic Mice
Mol Pharmacol 1997 52: 187-194. [Abstract] [Full Text] [PDF]

Yukihiro Kondo, James M. Rusnak, Dale G. Hoyt, Catherine E. Settineri, Bruce R. Pitt, and John S. Lazo: Enhanced Apoptosis in Metallothionein Null Cells
Mol Pharmacol 1997 52: 195-201. [Abstract] [Full Text] [PDF]

Jennifer L. Holmes and Richard S. Pollenz: Determination of Aryl Hydrocarbon Receptor Nuclear Translocator Protein Concentration and Subcellular Localization in Hepatic and Nonhepatic Cell Culture Lines: Development of Quantitative Western Blotting Protocols for Calculation of Aryl Hydrocarbon Receptor and Aryl Hydrocarbon Receptor Nuclear Translocator Protein in Total Cell Lysates
Mol Pharmacol 1997 52: 202-211. [Abstract] [Full Text] [PDF]

Christian P. Strassburg, Karl Oldhafer, Michael P. Manns, and Robert H. Tukey: Differential Expression of the UGT1A Locus in Human Liver, Biliary, and Gastric Tissue: Identification of UGT1A7 and UGT1A10 Transcripts in Extrahepatic Tissue
Mol Pharmacol 1997 52: 212-220. [Abstract] [Full Text] [PDF]

Daniel S. Cowen, Perry B. Molinoff, and David R. Manning: 5-Hydroxytryptamine_1A Receptor-Mediated Increases in Receptor Expression and Activation of Nuclear Factor- $kappa$ B in Transfected Chinese Hamster Ovary Cells
Mol Pharmacol 1997 52: 221-226. [Abstract] [Full Text] [PDF]

Dicky G. Abraham, Elka M. Nutt, Rodney A. Bednar, Bohumil Bednar, Robert J. Gould, and Le T. Duong: Arginine-Glycine-Aspartic Acid Mimics Can Identify a Transitional Activation State of Recombinant $alpha$ IIb $beta$ 3 in Human Embryonic Kidney 293 Cells
Mol Pharmacol 1997 52: 227-236. [Abstract] [Full Text] [PDF]

Joseph Simon, Emma J. Kidd, Fiona M. Smith, Iain P. Chessell, Ruth Murrell-Lagnado, Patrick P. A. Humphrey, and Eric A. Barnard: Localization and Functional Expression of Splice Variants of the P2X₂ Receptor
Mol Pharmacol 1997 52: 237-248. [Abstract] [Full Text] [PDF]

Lucio Tentori, Laura Orlando, Pedro Miguel Lacal, Elena Benincasa, Isabella Faraoni, Enzo Bonmassar, Stefania D'Atri, and Grazia Graziani: Inhibition of O⁶-Alkylguanine DNA-Alkyltransferase or Poly(ADP-ribose) Polymerase Increases Susceptibility of Leukemic Cells to Apoptosis Induced by Temozolomide
Mol Pharmacol 1997 52: 249-258. [Abstract] [Full Text] [PDF]

B. L. Roth, M. Shoham, M. S. Choudhary, and N. Khan: Identification of Conserved Aromatic Residues Essential for Agonist Binding and Second Messenger Production at 5-Hydroxytryptamine_2A Receptors
Mol Pharmacol 1997 52: 259-266. [Abstract] [Full Text] [PDF]

Alexandra Kikonyogo and Regina Pietruszko: Cimetidine and Other H₂-Receptor Antagonists as Inhibitors of Human E3 Aldehyde Dehydrogenase
Mol Pharmacol 1997 52: 267-271. [Abstract] [Full Text] [PDF]

George Bot, Allan D. Blake, Shuixing Li, and Terry Reisine: Opioid Regulation of the Mouse $delta$ -Opioid Receptor Expressed in Human Embryonic Kidney 293 Cells
Mol Pharmacol 1997 52: 272-281. [Abstract] [Full Text] [PDF]

Lee R. Shekter, Ronald Taussig, Samantha E. Gillard, and Richard J. Miller: Regulation of Human Neuronal Calcium Channels by G Protein $beta$ $gamma$ Subunits Expressed in Human Embryonic Kidney 293 Cells
Mol Pharmacol 1997 52: 282-291. [Abstract] [Full Text] [PDF]

Catherine Oiry, Didier Gagne, Éric Cottin, Nicole Bernad, Jean-Claude Galleyrand, Gilbert Bergé, Marie-Francoise Lignon, Patrick Eldin, Martine Le Cunff, Jean Léger, Pascal Clerc, Daniel Fourmy, and Jean Martinez: Cholecystokinin_B Receptor from Human Jurkat Lymphoblastic T Cells Is Involved in Activator Protein-1-Responsive Gene Activation
Mol Pharmacol 1997 52: 292-299. [Abstract] [Full Text] [PDF]

David Siegel, Emiko M. Bolton, Jeanne A. Burr, Daniel C. Liebler, and David Ross: The Reduction of $alpha$ -Tocopherolquinone by Human NAD(P)H:Quinone Oxidoreductase: The Role of $alpha$ -Tocopherolhydroquinone as a Cellular Antioxidant
Mol Pharmacol 1997 52: 300-305. [Abstract] [Full Text] [PDF]

Jiefa Wang, Jialin Zheng, Jodi L. Anderson, and Myron L. Toews: A Mutation in the Hamster $alpha$ _1B-Adrenergic Receptor that Differentiates Two Steps in the Pathway of Receptor Internalization
Mol Pharmacol 1997 52: 306-313. [Abstract] [Full Text] [PDF]

Antonio E. Lacerda, Mary-Louise Roy, Eric W. Lewis, and David Rampe: Interactions of the Nonsedating Antihistamine Loratadine with a Kv1.5-Type Potassium Channel Cloned from Human Heart
Mol Pharmacol 1997 52: 314-322. [Abstract] [Full Text] [PDF]

Gilles Klopman, Leming M. Shi, and Avner Ramu: Quantitative Structure-Activity Relationship of Multidrug Resistance Reversal Agents
Mol Pharmacol 1997 52: 323-334. [Abstract] [Full Text] [PDF]

Errata:

: Correction for vol. 50, p. 1619
Mol Pharmacol 1997 52: 335. [Full Text] [PDF]

: Correction for vol. 51, p. 922
Mol Pharmacol 1997 52: 335. [Full Text]

Cover Caption:

About the cover: Rapid agonist-induced sequestration of a GFP-tagged $beta$ 2-adrenergic receptor. A fusion protein was constructedthat consisted of the S65T mutant of green fluorescent protein(GFP) attached to the carboxyl terminus of the $beta$ 2-adrenergic receptor.The GFP tag did not interfere with ligand recognition, G proteincoupling or internalization. Left, when expressed in HEK 293 cells,receptor is distributed diffusely over the surface membrane. Right,5 min after exposure to 10 µM isoproterenol, receptors are internalizedwithin endosomal vesicular membranes. The left and right panelsare two different cells representative of control and agonist-treatedpopulations. From Barak, L. S., S. S. G. Ferguson, J. Zhang, C.Martenson, T. Meyer, and M. C. Caron. Internal trafficking andsurface mobility of a functionally intact $beta$ 2-adrenergic receptor-greenfluorescent protein conjugate. Mol. Pharmacol. 51:177-184(1997).