Mol Pharm -- Table of Contents (58 [4])

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October 2000; 58 (4)   [Index by Author] [Cover Caption]

       Minireview

       Accelerated Communications

       Articles

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Minireview:

Miles D. Houslay and Walter Kolch: Cell-Type Specific Integration of Cross-Talk between Extracellular Signal-Regulated Kinase and cAMP Signaling
Mol Pharmacol 2000 58: 659-668. [Full Text] [PDF]

Accelerated Communications:

Raymond D. Price and Elaine Sanders-Bush: RNA Editing of the Human Serotonin 5-HT_2C Receptor Delays Agonist-Stimulated Calcium Release
Mol Pharmacol 2000 58: 859-862. [Abstract] [Full Text] [PDF]

Lu-Bin Lan, James T. Dalton, and Erin G. Schuetz: Mdr1 Limits CYP3A Metabolism in Vivo
Mol Pharmacol 2000 58: 863-869. [Abstract] [Full Text] [PDF]

Joseph A. Hedrick, Kelley Morse, LiXin Shan, Xudong Qiao, Ling Pang, Suke Wang, Thomas Laz, Eric L. Gustafson, Marvin Bayne, and Frederick J. Monsma, Jr.: Identification of a Human Gastrointestinal Tract and Immune System Receptor for the Peptide Neuromedin U
Mol Pharmacol 2000 58: 870-875. [Abstract] [Full Text] [PDF]

Articles:

Iain J. McFadyen, Hani Houshyar, Lee-Yuan Liu-Chen, James H. Woods, and John R. Traynor: The Steroid 17 $alpha$ -Acetoxy-6-dimethylaminomethyl-21-fluoro-3-ethoxy-pregna-3,5-dien-20-one (SC17599) Is a Selective µ-Opioid Agonist: Implications for the µ-Opioid Pharmacophore
Mol Pharmacol 2000 58: 669-676. [Abstract] [Full Text] [PDF]

Kelly D. Karpa, Ridwan Lin, Nadine Kabbani, and Robert Levenson: The Dopamine D3 Receptor Interacts with Itself and the Truncated D3 Splice Variant D3nf: D3-D3nf Interaction Causes Mislocalization of D3 Receptors
Mol Pharmacol 2000 58: 677-683. [Abstract] [Full Text] [PDF]

Gilles Auzou, Jérôme Fagart, Anny Souque, Chantal Hellal-Lévy, Jean-Marie Wurtz, Dino Moras, and Marie-Edith Rafestin-Oblin: A Single Amino Acid Mutation of Ala-773 in the Mineralocorticoid Receptor Confers Agonist Properties to 11 $beta$ -Substituted Spirolactones
Mol Pharmacol 2000 58: 684-691. [Abstract] [Full Text] [PDF]

Masuhide Yakehiro, Tsunetsugu Yuki, Kaoru Yamaoka, Toshiaki Furue, Yasuo Mori, Keiji Imoto, and Issei Seyama: An Analysis of the Variations in Potency of Grayanotoxin Analogs in Modifying Frog Sodium Channels of Differing Subtypes
Mol Pharmacol 2000 58: 692-700. [Abstract] [Full Text] [PDF]

Aaron M. Robida, Kaiming Xu, Michelle L. Ellington, and T. J. Murphy: Cyclosporin A Selectively Inhibits Mitogen-Induced Cyclooxygenase-2 Gene Transcription in Vascular Smooth Muscle Cells
Mol Pharmacol 2000 58: 701-708. [Abstract] [Full Text] [PDF]

Sandrine Le Mée, Françoise Chaminade, Charlotte Delaporte, Judith Markovits, Jean-Marie Saucier, and Alain Jacquemin-Sablon: Cellular Resistance to the Antitumor DNA Topoisomerase II Inhibitor S16020-2: Importance of the N-[2(Dimethylamino)ethyl]carbamoyl Side Chain
Mol Pharmacol 2000 58: 709-718. [Abstract] [Full Text] [PDF]

Astrid Scheschonka, Carmen W. Dessauer, Srikumar Sinnarajah, Peter Chidiac, Chong-Shan Shi, and John H. Kehrl: RGS3 Is a GTPase-Activating Protein for G_i and G_q and a Potent Inhibitor of Signaling by GTPase-Deficient Forms of G_q and G₁₁
Mol Pharmacol 2000 58: 719-728. [Abstract] [Full Text] [PDF]

Regina M. Sullivan, Michael Stone, John F. Marshall, Florian Uberall, and Susan A. Rotenberg: Photo-Induced Inactivation of Protein Kinase C $alpha$ by Dequalinium Inhibits Motility of Murine Melanoma Cells
Mol Pharmacol 2000 58: 729-737. [Abstract] [Full Text] [PDF]

Itzhak Goldwaser, Sun Qian, Eytan Gershonov, Mati Fridkin, and Yoram Shechter: Organic Vanadium Chelators Potentiate Vanadium-Evoked Glucose Metabolism In Vitro and In Vivo: Establishing Criteria for Optimal Chelators
Mol Pharmacol 2000 58: 738-746. [Abstract] [Full Text] [PDF]

Yushu Rao, Ewa Hoffmann, Mohammad Zia, Laurent Bodin, Marilyn Zeman, Edward M. Sellers, and Rachel F. Tyndale: Duplications and Defects in the CYP2A6 Gene: Identification, Genotyping, and In Vivo Effects on Smoking
Mol Pharmacol 2000 58: 747-755. [Abstract] [Full Text] [PDF]

Martin Davies, J. Glen Newell, Jason M. C. Derry, Ian L. Martin, and Susan M. J. Dunn: Characterization of the Interaction of Zopiclone with $gamma$ -Aminobutyric Acid Type A Receptors
Mol Pharmacol 2000 58: 756-762. [Abstract] [Full Text] [PDF]

Stephane Supplisson and Dominique Chesnoy-Marchais: Glycine Receptor $beta$ Subunits Play a Critical Role in Potentiation of Glycine Responses by ICS-205,930
Mol Pharmacol 2000 58: 763-770. [Abstract] [Full Text] [PDF]

Björn Kull, Per Svenningsson, and Bertil B. Fredholm: Adenosine A_2A Receptors are Colocalized with and Activate G_olf in Rat Striatum
Mol Pharmacol 2000 58: 771-777. [Abstract] [Full Text] [PDF]

Rashid A. Giniatullin, Elena M. Sokolova, Silvia Di Angelantonio, Andrei Skorinkin, Maria V. Talantova, and Andrea Nistri: Rapid Relief of Block by Mecamylamine of Neuronal Nicotinic Acetylcholine Receptors of Rat Chromaffin Cells In Vitro: An Electrophysiological and Modeling Study
Mol Pharmacol 2000 58: 778-787. [Abstract] [Full Text] [PDF]

Robin L. Haynes, Luke Szweda, Kerry Pickin, Mark E. Welker, and Alan J. Townsend: Structure-Activity Relationships for Growth Inhibition and Induction of Apoptosis by 4-Hydroxy-2-nonenal in Raw 264.7 Cells
Mol Pharmacol 2000 58: 788-794. [Abstract] [Full Text] [PDF]

Jian-Guo Li, Jeffrey L. Benovic, and Lee-Yuan Liu-Chen: Mechanisms of Agonist-Induced Down-Regulation of the Human $kappa$ -Opioid Receptor: Internalization Is Required for Down-Regulation
Mol Pharmacol 2000 58: 795-801. [Abstract] [Full Text] [PDF]

Amy C. Arai, Markus Kessler, Gary Rogers, and Gary Lynch: Effects of the Potent Ampakine CX614 on Hippocampal and Recombinant AMPA Receptors: Interactions with Cyclothiazide and GYKI 52466
Mol Pharmacol 2000 58: 802-813. [Abstract] [Full Text] [PDF]

Daniel Rueda, Ismael Galve-Roperh, Amador Haro, and Manuel Guzmán: The CB₁ Cannabinoid Receptor Is Coupled to the Activation of c-Jun N-Terminal Kinase
Mol Pharmacol 2000 58: 814-820. [Abstract] [Full Text] [PDF]

Stéphane Schaak, Cécile Cayla, Anastasios Lymperopoulos, Christodoulos Flordellis, Daniel Cussac, Colette Denis, and Hervé Paris: Transcriptional Down-Regulation of the Human $alpha$ 2C-Adrenergic Receptor by cAMP
Mol Pharmacol 2000 58: 821-827. [Abstract] [Full Text] [PDF]

Claudie Hecquet, Fulong Tan, Branislav M. Marcic, and Ervin G. Erdös: Human Bradykinin B₂ Receptor Is Activated by Kallikrein and Other Serine Proteases
Mol Pharmacol 2000 58: 828-836. [Abstract] [Full Text] [PDF]

Yoshikazu Miwa, Toshiyuki Sasaguri, Hiroyasu Inoue, Yoji Taba, Akio Ishida, and Takeo Abumiya: 15-Deoxy- $Delta$ ^12,14-prostaglandin J₂ Induces G₁ Arrest and Differentiation Marker Expression in Vascular Smooth Muscle Cells
Mol Pharmacol 2000 58: 837-844. [Abstract] [Full Text] [PDF]

Masahiro Tohkin, Morio Fukuhara, Guillermo Elizondo, Shuhei Tomita, and Frank J. Gonzalez: Aryl Hydrocarbon Receptor Is Required for p300-Mediated Induction of DNA Synthesis by Adenovirus E1A
Mol Pharmacol 2000 58: 845-851. [Abstract] [Full Text] [PDF]

Kevin W. Gaido, Susan C. Maness, Donald P. McDonnell, Shangara S. Dehal, David Kupfer, and Stephen Safe: Interaction of Methoxychlor and Related Compounds with Estrogen Receptor $alpha$ and $beta$ , and Androgen Receptor: Structure-Activity Studies
Mol Pharmacol 2000 58: 852-858. [Abstract] [Full Text] [PDF]

Cover Caption:

About the cover: Model of the receptor-G protein complex. The G protein heterotrimer is an $alpha$ _t/ $alpha$ _i1 chimera complexed with $beta$ _t $gamma$ _t(Lambright et al., 1996). The receptor model is the MII rhodopsinmodel (Pogozheva et al., 1997). Positioning of the heterotrimerrelative to the receptor is based on the model in Bourne (1997).The GTPase domain of the $alpha$ -subunit is light blue. The helicaldomain of the $alpha$ -subunit is pink. The GDP is yellow. Switch I isdark blue, switch II is green, and switch III is magenta. The $alpha$ 2/ $beta$ 4 loop is yellow, the $alpha$ 3/ $beta$ 5 loop is orange, and the $alpha$ 4/ $beta$ 6loop is red. The carboxyl terminus (labeled C) of the $alpha$ -subunitis magenta. Selected regions of secondary structure in the $alpha$ -subunit,including the amino-terminal $alpha$ -helix ( $alpha$ N), are indicated. The $beta$ -strands of the $beta$ -subunit are orange, and the amino-terminalhelix and connecting loops are yellow. the $gamma$ -subunit is white.Receptor helices are numbered, and those connected to each otherby an intracellular loop are the same color. These figures weredrawn using MidasPlus, developed by the Computer Graphics Laboratoryat the University of California at San Francisco. From GrishnaG and Berlot CH (2000) A surface-exposed region of G_s inwhich substitutions decrease receptor-mediated activation andincrease receptor affinity. Mol Pharmacol 57:1081-1092.