Perspective:

Jon W. Johnson

Acid Tests of N-Methyl-D-aspartate Receptor Gating Basics
Mol Pharmacol 2003 63: 1199-1201. [Full Text] [PDF]  

Dianne M. Perez

The Evolutionarily Triumphant G-Protein-Coupled Receptor
Mol Pharmacol 2003 63: 1202-1205. [Full Text] [PDF]  

David S. Bredt

Nitric Oxide Signaling in Brain: Potentiating the Gain with YC-1
Mol Pharmacol 2003 63: 1206-1208. [Full Text] [PDF]  

Vincent Manganiello

Cyclic Nucleotide Phosphodiesterase 5 and Sildenafil: Promises Realized
Mol Pharmacol 2003 63: 1209-1211. [Full Text] [PDF]  

Accelerated Communications:

Chian-Ming Low, Polina Lyuboslavsky, Adam French, Phuong Le, Karen Wyatte, William H. Thiel, Edward M. Marchan, Kazuei Igarashi, Keiko Kashiwagi, Kim Gernert, Keith Williams, Stephen F. Traynelis, and Fang Zheng

Molecular Determinants of Proton-Sensitive N-Methyl-D-aspartate Receptor Gating
Mol Pharmacol 2003 63: 1212-1222. [Abstract] [Full Text] [PDF]  

Vincent Setola, Sandra J. Hufeisen, K. Jane Grande-Allen, Ivan Vesely, Richard A. Glennon, Bruce Blough, Richard B. Rothman, and Bryan L. Roth

3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") Induces Fenfluramine-Like Proliferative Actions on Human Cardiac Valvular Interstitial Cells in Vitro
Mol Pharmacol 2003 63: 1223-1229. [Abstract] [Full Text] [PDF]  

Articles:

Sami Väisänen, Mikael Peräkylä, Jouni I. Kärkkäinen, Milan R. Uskokovic, and Carsten Carlberg

Structural Evaluation of the Agonistic Action of a Vitamin D Analog with Two Side Chains Binding to the Nuclear Vitamin D Receptor
Mol Pharmacol 2003 63: 1230-1237. [Abstract] [Full Text] [PDF]  

Sandeep C. Pingle, Joseph F. Sanchez, Daniel M. Hallam, Andrea L. Williamson, Sanjay B. Maggirwar, and Vickram Ramkumar

Hypertonicity Inhibits Lipopolysaccharide-Induced Nitric Oxide Synthase Expression in Smooth Muscle Cells by Inhibiting Nuclear Factor B
Mol Pharmacol 2003 63: 1238-1247. [Abstract] [Full Text] [PDF]  

Edwin C. Chinje, Rachel L. Cowen, Jian Feng, Sanjeev P. Sharma, Natasha S. Wind, Adrian L. Harris, and Ian J. Stratford

Non-Nuclear Localized Human NOSII Enhances the Bioactivation and Toxicity of Tirapazamine (SR4233) in Vitro
Mol Pharmacol 2003 63: 1248-1255. [Abstract] [Full Text] [PDF]  

Robert Fredriksson, Malin C. Lagerström, Lars-Gustav Lundin, and Helgi B. Schiöth

The G-Protein-Coupled Receptors in the Human Genome Form Five Main Families. Phylogenetic Analysis, Paralogon Groups, and Fingerprints
Mol Pharmacol 2003 63: 1256-1272. [Abstract] [Full Text] [PDF]  

Zobeida Cruz-Monserrate, Hélène C. Vervoort, Ruoli Bai, David J. Newman, Stephen B. Howell, Gerrit Los, Jeffrey T. Mullaney, Michael D. Williams, George R. Pettit, William Fenical, and Ernest Hamel

Diazonamide A and a Synthetic Structural Analog: Disruptive Effects on Mitosis and Cellular Microtubules and Analysis of Their Interactions with Tubulin
Mol Pharmacol 2003 63: 1273-1280. [Abstract] [Full Text] [PDF]  

Mike F. Burbridge, Virginie Venot, Patrick J. Casara, Françoise Perron-Sierra, John A. Hickman, and Gordon C. Tucker

Decrease in Survival Threshold of Quiescent Colon Carcinoma Cells in the Presence of a Small Molecule Integrin Antagonist
Mol Pharmacol 2003 63: 1281-1288. [Abstract] [Full Text] [PDF]  

Elke Oetjen, Diana Baun, Stephan Beimesche, Doris Krause, Irmgard Cierny, Roland Blume, Corinna Dickel, Simone Wehner, and Willhart Knepel

Inhibition of Human Insulin Gene Transcription by the Immunosuppressive Drugs Cyclosporin A and Tacrolimus in Primary, Mature Islets of Transgenic Mice
Mol Pharmacol 2003 63: 1289-1295. [Abstract] [Full Text] [PDF]  

Stéphane Fourcade, Stéphane Savary, Catherine Gondcaille, Johannes Berger, Angela Netik, Françoise Cadepond, Martine El Etr, Brunhilde Molzer, and Maurice Bugaut

Thyroid Hormone Induction of the Adrenoleukodystrophy-Related Gene (ABCD2)
Mol Pharmacol 2003 63: 1296-1303. [Abstract] [Full Text] [PDF]  

Franz-Josef Braun, Omar Aziz, and James W. Putney, Jr.

2-Aminoethoxydiphenyl Borane Activates a Novel Calcium-Permeable Cation Channel
Mol Pharmacol 2003 63: 1304-1311. [Abstract] [Full Text] [PDF]  

Jillian G. Baker, Ian P. Hall, and Stephen J. Hill

Agonist Actions of "-Blockers" Provide Evidence for Two Agonist Activation Sites or Conformations of the Human ₁-Adrenoceptor
Mol Pharmacol 2003 63: 1312-1321. [Abstract] [Full Text] [PDF]  

Wei-Lin Chien, Keng-Chen Liang, Che-Ming Teng, Sheng-Chu Kuo, Fang-Yu Lee, and Wen-Mei Fu

Enhancement of Long-Term Potentiation by a Potent Nitric Oxide-Guanylyl Cyclase Activator, 3-(5-Hydroxymethyl-2-furyl)-1-benzyl-indazole
Mol Pharmacol 2003 63: 1322-1328. [Abstract] [Full Text] [PDF]  

S. Vailati, M. Moretti, R. Longhi, G. E. Rovati, F. Clementi, and C. Gotti

Developmental Expression of Heteromeric Nicotinic Receptor Subtypes in Chick Retina
Mol Pharmacol 2003 63: 1329-1337. [Abstract] [Full Text] [PDF]  

Vitalyi O. Rybin, Elena Pak, Sasha Alcott, and Susan F. Steinberg

Developmental Changes in ₂-Adrenergic Receptor Signaling in Ventricular Myocytes: the Role of Gi proteins and Caveolae Microdomains
Mol Pharmacol 2003 63: 1338-1348. [Abstract] [Full Text] [PDF]  

Ralf Gerhard, Harald John, Klaus Aktories, and Ingo Just

Thiol-Modifying Phenylarsine Oxide Inhibits Guanine Nucleotide Binding of Rho but Not of Rac GTPases
Mol Pharmacol 2003 63: 1349-1355. [Abstract] [Full Text] [PDF]  

Pamela J. White, Tania E. Webb, and Michael R. Boarder

Characterization of a Ca²⁺ Response to Both UTP and ATP at Human P2Y₁₁ Receptors: Evidence for Agonist-Specific Signaling
Mol Pharmacol 2003 63: 1356-1363. [Abstract] [Full Text] [PDF]  

Jackie D. Corbin, Mitsi A. Blount, James L. Weeks, II, Alfreda Beasley, Karl P. Kuhn, Yew S. J. Ho, Layla F. Saidi, James H. Hurley, Jun Kotera, and Sharron H. Francis

[³H]Sildenafil Binding to Phosphodiesterase-5 Is Specific, Kinetically Heterogeneous, and Stimulated by cGMP
Mol Pharmacol 2003 63: 1364-1372. [Abstract] [Full Text] [PDF]  

Maen Abdelrahim, Roger Smith, III, and Stephen Safe

Aryl Hydrocarbon Receptor Gene Silencing with Small Inhibitory RNA Differentially Modulates Ah-Responsiveness in MCF-7 and HepG2 Cancer Cells
Mol Pharmacol 2003 63: 1373-1381. [Abstract] [Full Text] [PDF]  

Hanlin Gao, Edith F. Yamasaki, Kenneth K. Chan, Linus L. Shen, and Robert M. Snapka

DNA Sequence Specificity for Topoisomerase II Poisoning by the Quinoxaline Anticancer Drugs XK469 and CQS
Mol Pharmacol 2003 63: 1382-1388. [Abstract] [Full Text] [PDF]  

Miduturu Srinivas and David C. Spray

Closure of Gap Junction Channels by Arylaminobenzoates
Mol Pharmacol 2003 63: 1389-1397. [Abstract] [Full Text] [PDF]  

Carla Nau, Sho-Ya Wang, and Ging Kuo Wang

Point Mutations at L1280 in Na_v1.4 Channel D3-S6 Modulate Binding Affinity and Stereoselectivity of Bupivacaine Enantiomers
Mol Pharmacol 2003 63: 1398-1406. [Abstract] [Full Text] [PDF]  

Xuenong Bo, Lin-Hua Jiang, Heather L. Wilson, Miran Kim, Geoffrey Burnstock, Annmarie Surprenant, and R. Alan North

Pharmacological and Biophysical Properties of the Human P2X₅ Receptor
Mol Pharmacol 2003 63: 1407-1416. [Abstract] [Full Text] [PDF]  

Johanna Nilsson, Michael Madeja, and Peter Århem

Local Anesthetic Block of Kv Channels: Role of the S6 Helix and the S5-S6 Linker for Bupivacaine Action
Mol Pharmacol 2003 63: 1417-1429. [Abstract] [Full Text] [PDF]  

Eugen Brailoiu and Nae J. Dun

Extra- and Intracellular Sphingosylphosphorylcholine Promote Spontaneous Transmitter Release from Frog Motor Nerve Endings
Mol Pharmacol 2003 63: 1430-1436. [Abstract] [Full Text] [PDF]  

Stefania Ceruti, Elena Beltrami, Paola Matarrese, Alessia Mazzola, Flaminio Cattabeni, Walter Malorni, and Maria P. Abbracchio

A Key Role for Caspase-2 and Caspase-3 in the Apoptosis Induced by 2-Chloro-2'-deoxy-adenosine (Cladribine) and 2-Chloro-adenosine in Human Astrocytoma Cells
Mol Pharmacol 2003 63: 1437-1447. [Abstract] [Full Text] [PDF]  

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