Minireview:

Graeme Milligan

Constitutive Activity and Inverse Agonists of G Protein-Coupled Receptors: a Current Perspective
Mol Pharmacol 2003 64: 1271-1276. [Abstract] [Full Text] [PDF]  

Perspectives:

Vincent Setola and Bryan L. Roth

Why Mice Are Neither Miniature Humans nor Small Rats: A Cautionary Tale Involving 5-Hydroxytryptamine-6 Serotonin Receptor Species Variants
Mol Pharmacol 2003 64: 1277-1278. [Full Text] [PDF]  

Kim E. Barrett

Loosening the Ties That Bind—Novel Strategy to Enhance Oral Bioavailability
Mol Pharmacol 2003 64: 1279-1282. [Full Text] [PDF]  

Articles:

J. Brek Eaton, Jian-Hong Peng, Katherine M. Schroeder, Andrew A. George, John D. Fryer, Chandra Krishnan, Lori Buhlman, Yen-Ping Kuo, Ortrud Steinlein, and Ronald J. Lukas

Characterization of Human 42-Nicotinic Acetylcholine Receptors Stably and Heterologously Expressed in Native Nicotinic Receptor-Null SH-EP1 Human Epithelial Cells
Mol Pharmacol 2003 64: 1283-1294. [Abstract] [Full Text] [PDF]  

Warren D. Hirst, Bjarke Abrahamsen, Frank E. Blaney, Andrew R. Calver, Lucia Aloj, Gary W. Price, and Andrew D. Medhurst

Differences in the Central Nervous System Distribution and Pharmacology of the Mouse 5-Hydroxytryptamine-6 Receptor Compared with Rat and Human Receptors Investigated by Radioligand Binding, Site-Directed Mutagenesis, and Molecular Modeling
Mol Pharmacol 2003 64: 1295-1308. [Abstract] [Full Text] [PDF]  

Laura A. Volpicelli-Daley, Anna Hrabovska, Ellen G. Duysen, Shawn M. Ferguson, Randy D. Blakely, Oksana Lockridge, and Allan I. Levey

Altered Striatal Function and Muscarinic Cholinergic Receptors in Acetylcholinesterase Knockout Mice
Mol Pharmacol 2003 64: 1309-1316. [Abstract] [Full Text] [PDF]  

B. A. Jordan, I. Gomes, C Rios, J. Filipovska, and L. A. Devi

Functional Interactions between µ Opioid and _2A-Adrenergic Receptors
Mol Pharmacol 2003 64: 1317-1324. [Abstract] [Full Text] [PDF]  

Karl A. Werbovetz, Dan L. Sackett, Dawn Delfín, Gautam Bhattacharya, Manar Salem, Tomasz Obrzut, Donna Rattendi, and Cyrus Bacchi

Selective Antimicrotubule Activity of N1-Phenyl-3,5-dinitro-N4,N4-di-n-propylsulfanilamide (GB-II-5) against Kinetoplastid Parasites
Mol Pharmacol 2003 64: 1325-1333. [Abstract] [Full Text] [PDF]  

Iris Lavon, Tatiana Sheinin, Sigal Meilin, Efrat Biton, Ayelet Weksler, Gilat Efroni, Avi Bar-Joseph, George Fink, and Ayelet Avraham

A Novel Synthetic Cannabinoid Derivative Inhibits Inflammatory Liver Damage via Negative Cytokine Regulation
Mol Pharmacol 2003 64: 1334-1341. [Abstract] [Full Text] [PDF]  

Qiming J. Wang, Tzan-Wei Fang, Dazhi Yang, Nancy E. Lewin, Johan Van Lint, Victor E. Marquez, and Peter M. Blumberg

Ligand Structure-Activity Requirements and Phospholipid Dependence for the Binding of Phorbol Esters to Protein Kinase D
Mol Pharmacol 2003 64: 1342-1348. [Abstract] [Full Text] [PDF]  

Charmaine Griffiths, Victoria Wykes, Tomas C. Bellamy, and John Garthwaite

A New and Simple Method for Delivering Clamped Nitric Oxide Concentrations in the Physiological Range: Application to Activation of Guanylyl Cyclase-Coupled Nitric Oxide Receptors
Mol Pharmacol 2003 64: 1349-1356. [Abstract] [Full Text] [PDF]  

Jillian G. Baker, Ian P. Hall, and Stephen J. Hill

Agonist and Inverse Agonist Actions of -Blockers at the Human ₂-Adrenoceptor Provide Evidence for Agonist-Directed Signaling
Mol Pharmacol 2003 64: 1357-1369. [Abstract] [Full Text] [PDF]  

Marco Corazzari, Penny E. Lovat, Serafina Oliverio, Andy D. J. Pearson, Mauro Piacentini, and Christopher P. F. Redfern

Growth and DNA Damage-Inducible Transcription Factor 153 Mediates Apoptosis in Response to Fenretinide but Not Synergy between Fenretinide and Chemotherapeutic Drugs in Neuroblastoma
Mol Pharmacol 2003 64: 1370-1378. [Abstract] [Full Text] [PDF]  

Michelle A. Uberti, Randy A. Hall, and Kenneth P. Minneman

Subtype-Specific Dimerization of ₁-Adrenoceptors: Effects on Receptor Expression and Pharmacological Properties
Mol Pharmacol 2003 64: 1379-1390. [Abstract] [Full Text] [PDF]  

Mariana M. Belcheva, Yun Tan, Virginia M. Heaton, Amy L. Clark, and Carmine J. Coscia

µ Opioid Transactivation and Down-Regulation of the Epidermal Growth Factor Receptor in Astrocytes: Implications for Mitogen-Activated Protein Kinase Signaling
Mol Pharmacol 2003 64: 1391-1401. [Abstract] [Full Text] [PDF]  

Yun Dai, Paul Dent, and Steven Grant

Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Promotes Mitochondrial Dysfunction and Apoptosis Induced by 7-Hydroxystaurosporine and Mitogen-Activated Protein Kinase Kinase Inhibitors in Human Leukemia Cells That Ectopically Express Bcl-2 and Bcl-xL
Mol Pharmacol 2003 64: 1402-1409. [Abstract] [Full Text] [PDF]  

Po-Wei Lee and Yu-May Lee

Transcriptional Regulation of µ Opioid Receptor Gene by cAMP Pathway
Mol Pharmacol 2003 64: 1410-1418. [Abstract] [Full Text] [PDF]  

Tsong-Long Hwang, Hsiu-Wen Hung, Shu-Hui Kao, Che-Ming Teng, Chin-Chung Wu, and Samantha Ju-San Cheng

Soluble Guanylyl Cyclase Activator YC-1 Inhibits Human Neutrophil Functions through a cGMP-Independent but cAMP-Dependent Pathway
Mol Pharmacol 2003 64: 1419-1427. [Abstract] [Full Text] [PDF]  

Sofia Movérare, Johanna Dahllund, Niklas Andersson, Ulrika Islander, Hans Carlsten, Jan-Åke Gustafsson, Stefan Nilsson, and Claes Ohlsson

Estren Is a Selective Estrogen Receptor Modulator with Transcriptional Activity
Mol Pharmacol 2003 64: 1428-1433. [Abstract] [Full Text] [PDF]  

Kimberly R. Kalli, Kathryn E. Devine, Myles C. Cabot, Christina R. Arnt, Michael P. Heldebrant, Phyllis A. Svingen, Charles Erlichman, Lynn C. Hartmann, Cheryl A. Conover, and Scott H. Kaufmann

Heterogeneous Role of Caspase-8 in Fenretinide-Induced Apoptosis in Epithelial Ovarian Carcinoma Cell Lines
Mol Pharmacol 2003 64: 1434-1443. [Abstract] [Full Text] [PDF]  

Nicole Struckmann, Sandra Schwering, Silke Wiegand, Anja Gschnell, Masahisa Yamada, Wolfgang Kummer, Jürgen Wess, and Rainer V. Haberberger

Role of Muscarinic Receptor Subtypes in the Constriction of Peripheral Airways: Studies on Receptor-Deficient Mice
Mol Pharmacol 2003 64: 1444-1451. [Abstract] [Full Text] [PDF]  

Takeo Nakanishi, L. Austin Doyle, Bret Hassel, Yuetong Wei, Kenneth S. Bauer, Suhlan Wu, David W. Pumplin, Hong-Bin Fang, and Douglas D. Ross

Functional Characterization of Human Breast Cancer Resistance Protein (BCRP, ABCG2) Expressed in the Oocytes of Xenopus laevis
Mol Pharmacol 2003 64: 1452-1462. [Abstract] [Full Text] [PDF]  

Anthony H. Stonehouse, Megumi Adachi, Elisabeth C. Walcott, and Frederick S. Jones

Caffeine Regulates Neuronal Expression of the Dopamine 2 Receptor Gene
Mol Pharmacol 2003 64: 1463-1473. [Abstract] [Full Text] [PDF]  

Fu-Yue Zeng, Alison J. McLean, Graeme Milligan, Michael Lerner, Derek T. Chalmers, and Dominic P. Behan

Ligand Specific Up-Regulation of a Renilla reniformis Luciferase-Tagged, Structurally Unstable Muscarinic M₃ Chimeric G Protein-Coupled Receptor
Mol Pharmacol 2003 64: 1474-1484. [Abstract] [Full Text] [PDF]  

Todd Davidson, Konstantin Salnikow, and Max Costa

Hypoxia Inducible Factor-1-Independent Suppression of Aryl Hydrocarbon Receptor-Regulated Genes by Nickel
Mol Pharmacol 2003 64: 1485-1493. [Abstract] [Full Text] [PDF]  

Uwe Wenzel, Sabine Kuntz, and Hannelore Daniel

Nitric Oxide Levels in Human Preneoplastic Colonocytes Determine Their Susceptibility toward Antineoplastic Agents
Mol Pharmacol 2003 64: 1494-1502. [Abstract] [Full Text] [PDF]  

Sung Ho Hahm, Yun Chen, Charles Vinson, and Lee E. Eiden

A Calcium-Initiated Signaling Pathway Propagated through Calcineurin and cAMP Response Element-Binding Protein Activates Proenkephalin Gene Transcription after Depolarization
Mol Pharmacol 2003 64: 1503-1511. [Abstract] [Full Text] [PDF]  

Jing Zhang, Frank Visser, Mark F. Vickers, Thack Lang, Morris J. Robins, Lars P.C. Nielsen, Ireneusz Nowak, Stephen A. Baldwin, James D. Young, and Carol E. Cass

Uridine Binding Motifs of Human Concentrative Nucleoside Transporters 1 and 3 Produced in Saccharomyces cerevisiae
Mol Pharmacol 2003 64: 1512-1520. [Abstract] [Full Text] [PDF]  

Takayuki Ikezoe, Yang Yang, David Heber, Hirokuni Taguchi, and H. Phillip Koeffler

PC-SPES: A Potent Inhibitor of Nuclear Factor-B Rescues Mice from Lipopolysaccharide-Induced Septic Shock
Mol Pharmacol 2003 64: 1521-1529. [Abstract] [Full Text] [PDF]  

Staffan Tavelin, Kei Hashimoto, John Malkinson, Lucia Lazorova, Istvan Toth, and Per Artursson

A New Principle for Tight Junction Modulation Based on Occludin Peptides
Mol Pharmacol 2003 64: 1530-1540. [Abstract] [Full Text] [PDF]  

Doo-Sup Choi, Hannah Young, Thomas McMahon, Dan Wang, and Robert O. Messing

The Mouse RACK1 Gene Is Regulated by Nuclear Factor-B and Contributes to Cell Survival
Mol Pharmacol 2003 64: 1541-1548. [Abstract] [Full Text] [PDF]  

Marc B. Cox and Charles A. Miller, III

Pharmacological and Genetic Analysis of 90-kDa Heat Shock Isoprotein-Aryl Hydrocarbon Receptor Complexes
Mol Pharmacol 2003 64: 1549-1556. [Abstract] [Full Text] [PDF]  

Heidi Figler, Ray A. Olsson, and Joel Linden

Allosteric Enhancers of A₁ Adenosine Receptors Increase Receptor-G Protein Coupling and Counteract Guanine Nucleotide Effects on Agonist Binding
Mol Pharmacol 2003 64: 1557-1564. [Abstract] [Full Text] [PDF]  

Jean-Claude Marie, Christiane Rouyer-Fessard, Alain Couvineau, Pascal Nicole, Hélène Devaud, Jamel El Benna, and Marc Laburthe

Serine 447 in the Carboxyl Tail of Human VPAC₁ Receptor Is Crucial for Agonist-Induced Desensitization but Not Internalization of the Receptor
Mol Pharmacol 2003 64: 1565-1574. [Abstract] [Full Text] [PDF]  

M. E. O'Leary, M. Digregorio, and M. Chahine

Closing and Inactivation Potentiate the Cocaethylene Inhibition of Cardiac Sodium Channels by Distinct Mechanisms
Mol Pharmacol 2003 64: 1575-1585. [Abstract] [Full Text] [PDF]  

Elicia B. E. Berry, Roberta Eykholt, Rachel J. A. Helliwell, R. Stewart Gilmour, Murray D. Mitchell, and Keith W. Marvin

Peroxisome Proliferator-Activated Receptor Isoform Expression Changes in Human Gestational Tissues with Labor at Term
Mol Pharmacol 2003 64: 1586-1590. [Abstract] [Full Text] [PDF]  

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