Perspectives:

Chris J. van Koppen and Karl H. Jakobs

Arrestin-Independent Internalization of G Protein-Coupled Receptors
Mol Pharmacol 2004 66: 365-367. [Full Text] [PDF]  

Articles:

Joo-Young Im, Doyeun Kim, Kang-Woo Lee, Jung-Bin Kim, Ja-Kyeong Lee, Dong Sik Kim, Young Ik Lee, Kwon-Soo Ha, Cheol O Joe, and Pyung-Lim Han

COX-2 Regulates the Insulin-Like Growth Factor I–Induced Potentiation of Zn²⁺-Toxicity in Primary Cortical Culture
Mol Pharmacol 2004 66: 368-376. [Abstract] [Full Text] [PDF]  

Zhangguo Chen, Rémi Gaudreau, Christian Le Gouill, Marek Rola-Pleszczynski, and Jana Stanková

Agonist-Induced Internalization of Leukotriene B₄ Receptor 1 Requires G-Protein-Coupled Receptor Kinase 2 but Not Arrestins
Mol Pharmacol 2004 66: 377-386. [Abstract] [Full Text] [PDF]  

Anika M. S. Hartz, Björn Bauer, Gert Fricker, and David S. Miller

Rapid Regulation of P-Glycoprotein at the Blood-Brain Barrier by Endothelin-1
Mol Pharmacol 2004 66: 387-394. Published online June 10, 2004; 10.1124/mol.104.001503 [Abstract] [Full Text] [PDF]  

Zhigang Zhang, Jin-Ying Wu, William N. Hait, and Jin-Ming Yang

Regulation of the Stability of P-Glycoprotein by Ubiquitination
Mol Pharmacol 2004 66: 395-403. Published online June 14, 2004; 10.1124/mol.104.001966 [Abstract] [Full Text] [PDF]  

Julia C. Kennedy, Sylvie Memet, and Peter G. Wells

Antisense Evidence for Nuclear Factor-B–Dependent Embryopathies Initiated by Phenytoin-Enhanced Oxidative Stress
Mol Pharmacol 2004 66: 404-412. [Abstract] [Full Text] [PDF]  

Björn Bauer, Anika M. S. Hartz, Gert Fricker, and David S. Miller

Pregnane X Receptor Up-Regulation of P-Glycoprotein Expression and Transport Function at the Blood-Brain Barrier
Mol Pharmacol 2004 66: 413-419. [Abstract] [Full Text] [PDF]  

Emily G. Severance, Hongling Zhang, Yolmari Cruz, Sergei Pakhlevaniants, Stephen H. Hadley, Jahanshah Amin, Lynn Wecker, Crystal Reed, and Javier Cuevas

The 7 Nicotinic Acetylcholine Receptor Subunit Exists in Two Isoforms that Contribute to Functional Ligand-Gated Ion Channels
Mol Pharmacol 2004 66: 420-429. Published online June 24, 2004; 10.1124/mol.104.000059 [Abstract] [Full Text] [PDF]  

Chrysoula Leontiou, Jeremy H. Lakey, and Caroline A. Austin

Mutation E522K in Human DNA Topoisomerase II Confers Resistance to Methyl N-(4'-(9-acridinylamino)-phenyl)carbamate hydrochloride and Methyl N-(4'-(9-acridinylamino)-3-methoxy-phenyl) methane sulfonamide but Hypersensitivity to Etoposide
Mol Pharmacol 2004 66: 430-439. [Abstract] [Full Text] [PDF]  

Chih-Hsin Tang, Rong-Sen Yang, Tsang-Hai Huang, Shing-Hwa Liu, and Wen-Mei Fu

Enhancement of Fibronectin Fibrillogenesis and Bone Formation by Basic Fibroblast Growth Factor via Protein Kinase C-Dependent Pathway in Rat Osteoblasts
Mol Pharmacol 2004 66: 440-449. [Abstract] [Full Text] [PDF]  

Makoto Sasaki, Hiroshi Suzuki, Jun Aoki, Kousei Ito, Peter J. Meier, and Yuichi Sugiyama

Prediction of in Vivo Biliary Clearance from the in Vitro Transcellular Transport of Organic Anions across a Double-Transfected Madin-Darby Canine Kidney II Monolayer Expressing Both Rat Organic Anion Transporting Polypeptide 4 and Multidrug Resistance Associated Protein 2
Mol Pharmacol 2004 66: 450-459. [Abstract] [Full Text] [PDF]  

Sonia Arora, Jin-Ming Yang, Ryutaro Utsumi, Tadashi Okamoto, Takashi Kitayama, and William N. Hait

P-Glycoprotein Mediates Resistance to Histidine Kinase Inhibitors
Mol Pharmacol 2004 66: 460-467. [Abstract] [Full Text] [PDF]  

Alexander K. Filippov, Jose M. Fernández-Fernández, Stephen J. Marsh, Joseph Simon, Eric A. Barnard, and David A. Brown

Activation and Inhibition of Neuronal G Protein-Gated Inwardly Rectifying K⁺ Channels by P2Y Nucleotide Receptors
Mol Pharmacol 2004 66: 468-477. [Abstract] [Full Text] [PDF]  

Simona Caporali, Sabrina Falcinelli, Giuseppe Starace, Maria Teresa Russo, Enzo Bonmassar, Josef Jiricny, and Stefania D'Atri

DNA Damage Induced by Temozolomide Signals to both ATM and ATR: Role of the Mismatch Repair System
Mol Pharmacol 2004 66: 478-491. [Abstract] [Full Text] [PDF]  

Chiung-Chun Huang, Samuel H. H. Chan, and Kuei-Sen Hsu

3-Morpholinylsydnonimine Inhibits Glutamatergic Transmission in Rat Rostral Ventrolateral Medulla via Peroxynitrite Formation and Adenosine Release
Mol Pharmacol 2004 66: 492-501. Published online May 26, 2004; 10.1124/mol.104.000554 [Abstract] [Full Text] [PDF]  

Sonya Barnes-Ellerbe, Karen E. Knudsen, and Alvaro Puga

2,3,7,8-Tetrachlorodibenzo-p-dioxin Blocks Androgen-Dependent Cell Proliferation of LNCaP Cells through Modulation of pRB Phosphorylation
Mol Pharmacol 2004 66: 502-511. Published online May 26, 2004; 10.1124/mol.104.000356 [Abstract] [Full Text] [PDF]  

Sara A. Carney, Richard E. Peterson, and Warren Heideman

2,3,7,8-Tetrachlorodibenzo-p-dioxin Activation of the Aryl Hydrocarbon Receptor/Aryl Hydrocarbon Receptor Nuclear Translocator Pathway Causes Developmental Toxicity through a CYP1A-Independent Mechanism in Zebrafish
Mol Pharmacol 2004 66: 512-521. [Abstract] [Full Text] [PDF]  

Marcella Funicello, Paola Conti, Marco De Amici, Carlo De Micheli, Tiziana Mennini, and Marco Gobbi

Dissociation of [³H]L-Glutamate Uptake from L-Glutamate-Induced [³H]D-Aspartate release by 3-Hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-4-carboxylic Acid and 3-Hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-6-carboxylic Acid, Two Conformationally Constrained Aspartate and Glutamate Analogs
Mol Pharmacol 2004 66: 522-529. [Abstract] [Full Text] [PDF]  

Marco Gruss, Alistair Mathie, William R. Lieb, and Nicholas P. Franks

The Two-Pore-Domain K⁺ Channels TREK-1 and TASK-3 Are Differentially Modulated by Copper and Zinc
Mol Pharmacol 2004 66: 530-537. [Abstract] [Full Text] [PDF]  

Lifen Zhang, Fu-Ming Zhou, and John A. Dani

Cholinergic Drugs for Alzheimer's Disease Enhance in Vitro Dopamine Release
Mol Pharmacol 2004 66: 538-544. Published online June 2, 2004; 10.1124/mol.104.000299 [Abstract] [Full Text] [PDF]  

Sonnet J. H. Arlander, Maoqing Dong, Xi-Qin Ding, Delia I. Pinon, and Laurence J. Miller

Key Differences in Molecular Complexes of the Cholecystokinin Receptor with Structurally Related Peptide Agonist, Partial Agonist, and Antagonist
Mol Pharmacol 2004 66: 545-552. Published online June 2, 2004; 10.1124/mol.104.001396 [Abstract] [Full Text] [PDF]  

Allan Y. Chen, Shyh-Jen Shih, Michael Hsiao, Mace L. Rothenberg, and Michelle Prudhomme

Induction of Radiosensitization by Indolocarbazole Derivatives: The Role of DNA Topoisomerase I
Mol Pharmacol 2004 66: 553-560. [Abstract] [Full Text] [PDF]  

Ming-Shyan Chang, Wen-Sen Lee, Bing-Chang Chen, Joen-Rong Sheu, and Chien-Huang Lin

YC-1-Induced Cyclooxygenase-2 Expression Is Mediated by cGMP-Dependent Activations of Ras, Phosphoinositide-3-OH-kinase, Akt, and Nuclear Factor-B in Human Pulmonary Epithelial Cells
Mol Pharmacol 2004 66: 561-571. [Abstract] [Full Text] [PDF]  

Andrew M. Siwkowski, Lisa A. Madge, Seongjoon Koo, Erin L. McMillan, Brett P. Monia, Jordan S. Pober, and Brenda F. Baker

Effects of Antisense Oligonucleotide-Mediated Depletion of Tumor Necrosis Factor (TNF) Receptor 1-Associated Death Domain Protein on TNF-Induced Gene Expression
Mol Pharmacol 2004 66: 572-579. [Abstract] [Full Text] [PDF]  

Bertrand Pourroy, Manon Carré, Stéphane Honoré, Véronique Bourgarel-Rey, Anna Kruczynski, Claudette Briand, and Diane Braguer

Low Concentrations of Vinflunine Induce Apoptosis in Human SK-N-SH Neuroblastoma Cells through a Postmitotic G₁ Arrest and a Mitochondrial Pathway
Mol Pharmacol 2004 66: 580-591. [Abstract] [Full Text] [PDF]  

Melissa A. Moss, Nicholas H. Varvel, Michael R. Nichols, Dana Kim Reed, and Terrone L. Rosenberry

Nordihydroguaiaretic Acid Does Not Disaggregate -Amyloid(1–40) Protofibrils but Does Inhibit Growth Arising from Direct Protofibril Association
Mol Pharmacol 2004 66: 592-600. [Abstract] [Full Text] [PDF]  

Steven J. Ennion, Andrew D. Powell, and Elizabeth P. Seward

Identification of the P2Y₁₂ Receptor in Nucleotide Inhibition of Exocytosis from Bovine Chromaffin Cells
Mol Pharmacol 2004 66: 601-611. Published online June 2, 2004; 10.1124/mol.104.000224 [Abstract] [Full Text] [PDF]  

Shankung Lin, Shiow-Chwen Tsai, Chun-Chung Lee, Bao-Wei Wang, Jer-Young Liou, and Kou-Gi Shyu

Berberine Inhibits HIF-1 Expression via Enhanced Proteolysis
Mol Pharmacol 2004 66: 612-619. [Abstract] [Full Text] [PDF]  

Sara E. Koehler and Robert D. Ladner

Small Interfering RNA-Mediated Suppression of dUTPase Sensitizes Cancer Cell Lines to Thymidylate Synthase Inhibition
Mol Pharmacol 2004 66: 620-626. [Abstract] [Full Text] [PDF]  

Sarit Bendetz-Nezer, Aviv Gazit, and Esther Priel

DNA Topoisomerase I As One of the Cellular Targets of Certain Tyrphostin Derivatives
Mol Pharmacol 2004 66: 627-634. [Abstract] [Full Text] [PDF]  

Stuart Emanuel, Robert H. Gruninger, Angel Fuentes-Pesquera, Peter J. Connolly, Jennifer A. Seamon, Susan Hazel, Rose Tominovich, Beth Hollister, Cheryl Napier, Michael R. D'Andrea, Michael Reuman, Gilles Bignan, Robert Tuman, Dana Johnson, David Moffatt, Mark Batchelor, Anne Foley, James O'Connell, Rodger Allen, Martin Perry, Linda Jolliffe, and Steven A. Middleton

A Vascular Endothelial Growth Factor Receptor-2 Kinase Inhibitor Potentiates the Activity of the Conventional Chemotherapeutic Agents Paclitaxel and Doxorubicin in Tumor Xenograft Models
Mol Pharmacol 2004 66: 635-647. Published online June 10, 2004; 10.1124/mol.104.000638 [Abstract] [Full Text] [PDF]  

Walter Sandtner, Julia Szendroedi, Touran Zarrabi, Eva Zebedin, Karlheinz Hilber, Ian Glaaser, Harry A. Fozzard, Samuel C. Dudley, and Hannes Todt

Lidocaine: A Foot in the Door of the Inner Vestibule Prevents Ultra-Slow Inactivation of a Voltage-Gated Sodium Channel
Mol Pharmacol 2004 66: 648-657. [Abstract] [Full Text] [PDF]  

Dmitriy Fayuk and Jerrel L. Yakel

Regulation of Nicotinic Acetylcholine Receptor Channel Function by Acetylcholinesterase Inhibitors in Rat Hippocampal CA1 Interneurons
Mol Pharmacol 2004 66: 658-666. Published online June 24, 2004; 10.1124/mol.104.000042 [Abstract] [Full Text] [PDF]  

Keigo Nakatani, Tohru Yamakuni, Nobuhiko Kondo, Tsutomu Arakawa, Kenji Oosawa, Susumu Shimura, Hiroyasu Inoue, and Yasushi Ohizumi

-Mangostin Inhibits Inhibitor-B Kinase Activity and Decreases Lipopolysaccharide-Induced Cyclooxygenase-2 Gene Expression in C6 Rat Glioma Cells
Mol Pharmacol 2004 66: 667-674. Published online June 24, 2004; 10.1124/mol.104.002626 [Abstract] [Full Text] [PDF]  

M. Imad Damaj, F. Ivy Carroll, J. Brek Eaton, Hernan A. Navarro, Bruce E. Blough, Sadiq Mirza, Ronald J. Lukas, and Billy R. Martin

Enantioselective Effects of Hydroxy Metabolites of Bupropion on Behavior and on Function of Monoamine Transporters and Nicotinic Receptors
Mol Pharmacol 2004 66: 675-682. Published online June 24, 2004; 10.1124/mol.104.001313 [Abstract] [Full Text] [PDF]  

Ching-Chow Chen, Man-Ping Chow, Wei-Chien Huang, Yi-Chu Lin, and Ya-Jen Chang

Flavonoids Inhibit Tumor Necrosis Factor--Induced Up-Regulation of Intercellular Adhesion Molecule-1 (ICAM-1) in Respiratory Epithelial Cells through Activator Protein-1 and Nuclear Factor-B: Structure-Activity Relationships
Mol Pharmacol 2004 66: 683-693. [Abstract] [Full Text] [PDF]  

Ning Li and Curtis D. Klaassen

Role of Liver-Enriched Transcription Factors in the Down-Regulation of Organic Anion Transporting Polypeptide 4 (Oatp4; Oatplb2; Slc21a10) by Lipopolysaccharide
Mol Pharmacol 2004 66: 694-701. [Abstract] [Full Text] [PDF]  

Sergey I. Zakharov, Tarik Smani, Yuliya Dobrydneva, Francisco Monje, Craig Fichandler, Peter F. Blackmore, and Victoria M. Bolotina

Diethylstilbestrol Is a Potent Inhibitor of Store-Operated Channels and Capacitative Ca²⁺ Influx
Mol Pharmacol 2004 66: 702-707. [Abstract] [Full Text] [PDF]  

Jürgen Borlak and Carolin Zwadlo

The Myosin ATPase Inhibitor 2,3-Butanedione monoxime Dictates Transcriptional Activation of Ion Channels and Ca²⁺-Handling Proteins
Mol Pharmacol 2004 66: 708-717. [Abstract] [Full Text] [PDF]  

Adam L. Numis, Erica L. Unger, Douglas L. Sheridan, Angela C. Chisnell, and Anne M. Andrews

The Role of Membrane and Vesicular Monoamine Transporters in the Neurotoxic and Hypothermic Effects of 1-Methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine (2'-NH₂-MPTP)
Mol Pharmacol 2004 66: 718-727. [Abstract] [Full Text] [PDF]  

F. Libert, J. Bonnefont, E. Bourinet, E. Doucet, A. Alloui, M. Hamon, J. Nargeot, and A. Eschalier

Acetaminophen: A Central Analgesic Drug That Involves a Spinal Tropisetron-Sensitive, Non–5-HT₃ Receptor-Mediated Effect
Mol Pharmacol 2004 66: 728-734. [Abstract] [Full Text] [PDF]  

Stéphanie C. M. Choisy, Jules C. Hancox, Lesley A. Arberry, A. Martyn Reynolds, Michael J. Shattock, and Andrew F. James

Evidence for a Novel K⁺ Channel Modulated by _1A-Adrenoceptors in Cardiac Myocytes
Mol Pharmacol 2004 66: 735-748. Published online June 24, 2004; 10.1124/mol.104.000760 [Abstract] [Full Text] [PDF]  

Defeng Wu and Arthur Cederbaum

Glutathione Depletion in CYP2E1-Expressing Liver Cells Induces Toxicity Due to the Activation of p38 Mitogen-Activated Protein Kinase and Reduction of Nuclear Factor-B DNA Binding Activity
Mol Pharmacol 2004 66: 749-760. Published online June 14, 2004; 10.1124/mol.104.002048 [Abstract] [Full Text] [PDF]  

Bin Li, Huijun Zhong, Todd Scheuer, and William A. Catterall

Functional Role of a C-Terminal G-Binding Domain of Ca_v2.2 Channels
Mol Pharmacol 2004 66: 761-769. [Abstract] [Full Text] [PDF]  

Errata:

Correction to "In silico simulation of inhibitor drug effects on nuclear factor--B pathway dynamics"
Mol Pharmacol 2004 66: 770. [Full Text] [PDF]  

Correction to "Preferential formation of MT1/MT2 melatonin receptor heterodimers with distinct ligand interaction properties compared with MT2 homodimers"
Mol Pharmacol 2004 66: 771. [Full Text] [PDF]  

Correction to "Ca²⁺ regulation of inositol 1,4,5-trisphosphate receptors: can Ca²⁺ function without calmodulin?"
Mol Pharmacol 2004 66: 772. [Full Text] [PDF]  

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