Minireview:

Jaime Kapitulnik

Bilirubin: An Endogenous Product of Heme Degradation with Both Cytotoxic and Cytoprotective Properties
Mol Pharmacol 2004 66: 773-779. Published online July 21, 2004; 10.1124/mol.104.002832 [Full Text] [PDF]  

Perspectives:

Johannes Rudolph

Targeting the Neighbor's Pool
Mol Pharmacol 2004 66: 780-782. Published online July 16, 2004; 10.1124/mol.104.004788 [Full Text] [PDF]  

Accelerated Communications:

Aurélie Mousnier, Hervé Leh, Jean-François Mouscadet, and Catherine Dargemont

Nuclear Import of HIV-1 Integrase Is Inhibited in Vitro by Styrylquinoline Derivatives
Mol Pharmacol 2004 66: 783-788. Published online July 9, 2004; 10.1124/mol.104.001735 [Abstract] [Full Text] [PDF]  

Articles:

Ding-Wu Shen, Xing-Jie Liang, Mary Ann Gawinowicz, and Michael M. Gottesman

Identification of Cytoskeletal [¹⁴C]Carboplatin-Binding Proteins Reveals Reduced Expression and Disorganization of Actin and Filamin in Cisplatin-Resistant Cell Lines
Mol Pharmacol 2004 66: 789-793. [Abstract] [Full Text] [PDF]  

Edmund K. K. Tung, Roy C. Y. Choi, Nina L. Siow, Joy X. S. Jiang, Karen K. Y. Ling, Joseph Simon, Eric A. Barnard, and Karl W. K. Tsim

P2Y₂ Receptor Activation Regulates the Expression of Acetylcholinesterase and Acetylcholine Receptor Genes at Vertebrate Neuromuscular Junctions
Mol Pharmacol 2004 66: 794-806. Published online July 16, 2004; 10.1124/mol.104.003269 [Abstract] [Full Text] [PDF]  

Mitsuhiko Yamada, Masaru Ishii, Hiroshi Hibino, and Yoshihisa Kurachi

Mutation in Nucleotide-Binding Domains of Sulfonylurea Receptor 2 Evokes Na-ATP-Dependent Activation of ATP-Sensitive K⁺ Channels: Implication for Dimerization of Nucleotide-Binding Domains to Induce Channel Opening
Mol Pharmacol 2004 66: 807-816. Published online July 16, 2004; 10.1124/mol.104.002717 [Abstract] [Full Text] [PDF]  

Alison K. Holzer, Goli Samimi, Kuniyuki Katano, Wiltrud Naerdemann, Xinjian Lin, Roohangiz Safaei, and Stephen B. Howell

The Copper Influx Transporter Human Copper Transport Protein 1 Regulates the Uptake of Cisplatin in Human Ovarian Carcinoma Cells
Mol Pharmacol 2004 66: 817-823. Published online June 30, 2004; 10.1124/mol.104.001198 [Abstract] [Full Text] [PDF]  

Marni Brisson, Theresa Nguyen, Andreas Vogt, Jack Yalowich, Angela Giorgianni, Dror Tobi, Ivet Bahar, Corey R. J. Stephenson, Peter Wipf, and John S. Lazo

Discovery and Characterization of Novel Small Molecule Inhibitors of Human Cdc25B Dual Specificity Phosphatase
Mol Pharmacol 2004 66: 824-833. Published online July 1, 2004; 10.1124/mol.104.001784 [Abstract] [Full Text] [PDF]  

Erica Rosemond, Minghua Wang, Yi Yao, Laura Storjohann, Thomas Stormann, Edwin C. Johnson, and David R. Hampson

Molecular Basis for the Differential Agonist Affinities of Group III Metabotropic Glutamate Receptors
Mol Pharmacol 2004 66: 834-842. Published online July 1, 2004; 10.1124/mol.104.002956 [Abstract] [Full Text] [PDF]  

Daniel P. Morris, R. Reyn Price, Michael P. Smith, Beilei Lei, and Debra A. Schwinn

Cellular Trafficking of Human _1a-Adrenergic Receptors Is Continuous and Primarily Agonist-Independent
Mol Pharmacol 2004 66: 843-854. Published online July 16, 2004; 10.1124/mol.104.000430 [Abstract] [Full Text] [PDF] Data Supplement  

Collin E. Davidson, Brian E. Reese, Melvin L. Billingsley, and Jong K. Yun

Stannin, A Protein That Localizes to the Mitochondria and Sensitizes NIH-3T3 Cells to Trimethyltin and Dimethyltin Toxicity
Mol Pharmacol 2004 66: 855-863. Published online July 21, 2004; 10.1124/mol.104.001719 [Abstract] [Full Text] [PDF]  

Balaji M. Rao, Ian Driver, Douglas A. Lauffenburger, and K. Dane Wittrup

Interleukin 2 (IL-2) Variants Engineered for Increased IL-2 Receptor -Subunit Affinity Exhibit Increased Potency Arising from a Cell Surface Ligand Reservoir Effect
Mol Pharmacol 2004 66: 864-869. [Abstract] [Full Text] [PDF]  

Peter Storz, Heike Döppler, and Alex Toker

Activation Loop Phosphorylation Controls Protein Kinase D-Dependent Activation of Nuclear Factor B
Mol Pharmacol 2004 66: 870-879. Published online June 29, 2004; 10.1124/mol.104.000687 [Abstract] [Full Text] [PDF]  

Valérie Capra, Alessio Veltri, Chiara Foglia, Luca Crimaldi, Aïda Habib, Marco Parenti, and G. Enrico Rovati

Mutational Analysis of the Highly Conserved ERY Motif of the Thromboxane A₂ Receptor: Alternative Role in G Protein-Coupled Receptor Signaling
Mol Pharmacol 2004 66: 880-889. Published online June 30, 2004; 10.1124/mol.104.001487 [Abstract] [Full Text] [PDF]  

Elena Rapizzi, Silvia Fossati, Flavio Moroni, and Alberto Chiarugi

Inhibition of Poly(ADP-Ribose) Glycohydrolase by Gallotannin Selectively Up-Regulates Expression of Proinflammatory Genes
Mol Pharmacol 2004 66: 890-898. Published online June 30, 2004; 10.1124/mol.104.000968 [Abstract] [Full Text] [PDF]  

Xin Qi, Toru Hosoi, Yasunobu Okuma, Masayuki Kaneko, and Yasuyuki Nomura

Sodium 4-Phenylbutyrate Protects against Cerebral Ischemic Injury
Mol Pharmacol 2004 66: 899-908. Published online June 29, 2004; 10.1124/mol.104.001339 [Abstract] [Full Text] [PDF]  

Philip A. Verhoef, Sylvia B. Kertesy, Mark Estacion, William P. Schilling, and George R. Dubyak

Maitotoxin Induces Biphasic Interleukin-1 Secretion and Membrane Blebbing in Murine Macrophages
Mol Pharmacol 2004 66: 909-920. [Abstract] [Full Text] [PDF]  

Qingming Ding, Robert Gros, Ian D. Gray, Ronald Taussig, Stephen S. G. Ferguson, and Ross D. Feldman

Raf Kinase Activation of Adenylyl Cyclases: Isoform-Selective Regulation
Mol Pharmacol 2004 66: 921-928. [Abstract] [Full Text] [PDF]  

John H. Streiff, Nenad O. Juranic, Slobodan I. Macura, David O. Warner, Keith A. Jones, and William J. Perkins

Saturation Transfer Difference Nuclear Magnetic Resonance Spectroscopy As a Method for Screening Proteins for Anesthetic Binding
Mol Pharmacol 2004 66: 929-935. [Abstract] [Full Text] [PDF]  

Aby Joiakim, Patricia A. Mathieu, Althea A. Elliott, and John J. Reiners, Jr.

Superinduction of CYP1A1 in MCF10A Cultures by Cycloheximide, Anisomycin, and Puromycin: A Process Independent of Effects on Protein Translation and Unrelated to Suppression of Aryl Hydrocarbon Receptor Proteolysis by the Proteasome
Mol Pharmacol 2004 66: 936-947. [Abstract] [Full Text] [PDF]  

Zhenglin Gu and Zhen Yan

Bidirectional Regulation of Ca²⁺/Calmodulin-Dependent Protein Kinase II Activity by Dopamine D₄ Receptors in Prefrontal Cortex
Mol Pharmacol 2004 66: 948-955. Published online June 30, 2004; 10.1124/mol.104.001404 [Abstract] [Full Text] [PDF]  

Ning Gao, Yun Dai, Mohamed Rahmani, Paul Dent, and Steven Grant

Contribution of Disruption of the Nuclear Factor-B Pathway to Induction of Apoptosis in Human Leukemia Cells by Histone Deacetylase Inhibitors and Flavopiridol
Mol Pharmacol 2004 66: 956-963. Published online July 2, 2004; 10.1124/mol.104.002014 [Abstract] [Full Text] [PDF]  

Anwar Y. Dunbar, Yasuhiko Kamada, Gary J. Jenkins, Ezra R. Lowe, Scott S. Billecke, and Yoichi Osawa

Ubiquitination and Degradation of Neuronal Nitric-Oxide Synthase in Vitro: Dimer Stabilization Protects the Enzyme from Proteolysis
Mol Pharmacol 2004 66: 964-969. Published online July 2, 2004; 10.1124/mol.104.000125 [Abstract] [Full Text] [PDF]  

Peng Cheng, Beatriz Kanterewicz, Pamela A. Hershberger, Kenneth S. McCarty, Jr., Billy W. Day, and Mark Nichols

Inhibition of Estrogen Receptor -Mediated Transcription by Antiestrogenic 1,1-Dichloro-2,2,3-triarylcyclopropanes
Mol Pharmacol 2004 66: 970-977. Published online July 2, 2004; 10.1124/mol.104.000752 [Abstract] [Full Text] [PDF]  

Susan C. Hernandez, Stefano Vicini, Yingxian Xiao, Martha I. Dávila-García, Robert P. Yasuda, Barry B. Wolfe, and Kenneth J. Kellar

The Nicotinic Receptor in the Rat Pineal Gland Is an 34 Subtype
Mol Pharmacol 2004 66: 978-987. Published online July 9, 2004; 10.1124/mol.104.002345 [Abstract] [Full Text] [PDF]  

Hua-Jun Feng, Matt T. Bianchi, and Robert L. Macdonald

Pentobarbital Differentially Modulates 13 and 132L GABA_A Receptor Currents
Mol Pharmacol 2004 66: 988-1003. Published online July 9, 2004; 10.1124/mol.104.002543 [Abstract] [Full Text] [PDF]  

Xianbin Tian, Maciej J. Zamek-Gliszczynski, Peijin Zhang, and Kim L. R. Brouwer

Modulation of Multidrug Resistance-Associated Protein 2 (Mrp2) and Mrp3 Expression and Function with Small Interfering RNA in Sandwich-Cultured Rat Hepatocytes
Mol Pharmacol 2004 66: 1004-1010. [Abstract] [Full Text] [PDF]  

Baoyong Sun, Xiqun Chen, Lu Xu, Carol Sterling, and A. William Tank

Chronic Nicotine Treatment Leads to Induction of Tyrosine Hydroxylase in Locus Ceruleus Neurons: The Role of Transcriptional Activation
Mol Pharmacol 2004 66: 1011-1021. Published online July 16, 2004; 10.1124/mol.104.001974 [Abstract] [Full Text] [PDF]  

Yingying Le, Pablo Iribarren, Ye Zhou, Wanghua Gong, Jinyue Hu, Xia Zhang, and Ji Ming Wang

Silencing the Formylpeptide Receptor FPR by Short-Interfering RNA
Mol Pharmacol 2004 66: 1022-1028. Published online July 16, 2004; 10.1124/mol.104.001982 [Abstract] [Full Text] [PDF]  

Susumu Nakamura, Barry Kreutz, Shihori Tanabe, Nobuchika Suzuki, and Tohru Kozasa

Critical Role of Lysine 204 in Switch I Region of G₁₃ for Regulation of p115RhoGEF and Leukemia-Associated RhoGEF
Mol Pharmacol 2004 66: 1029-1034. Published online July 16, 2004; 10.1124/mol.104.002287 [Abstract] [Full Text] [PDF]  

Krzysztof Lemke, Virginie Poindessous, Andrzej Skladanowski, and Annette K. Larsen

The Antitumor Triazoloacridone C-1305 Is a Topoisomerase II Poison with Unusual Properties
Mol Pharmacol 2004 66: 1035-1042. Published online July 16, 2004; 10.1124/mol.104.000703 [Abstract] [Full Text] [PDF]  

Johanna T. A. Meij, Carole L. Haselton, Kristin L. Hillman, Dhanasekaran Muralikrishnan, Manuchair Ebadi, and Lei Yu

Differential Mechanisms of Nitric Oxide- and Peroxynitrite-Induced Cell Death
Mol Pharmacol 2004 66: 1043-1053. Published online July 16, 2004; 10.1124/mol.104.001354 [Abstract] [Full Text] [PDF]  

Michiel de Bruin, Godefridus J. Peters, Ruud Oerlemans, Yehuda G. Assaraf, Allan J. Masterson, Auke D. Adema, Ben A. C. Dijkmans, Herbert M. Pinedo, and Gerrit Jansen

Sulfasalazine Down-Regulates the Expression of the Angiogenic Factors Platelet-Derived Endothelial Cell Growth Factor/Thymidine Phosphorylase and Interleukin-8 in Human Monocytic-Macrophage THP1 and U937 Cells
Mol Pharmacol 2004 66: 1054-1060. Published online July 21, 2004; 10.1124/mol.104.000315 [Abstract] [Full Text] [PDF]  

Hiroshi Tsuneki, Yueren You, Naoki Toyooka, Syota Kagawa, Soushi Kobayashi, Toshiyasu Sasaoka, Hideo Nemoto, Ikuko Kimura, and John A. Dani

Alkaloids Indolizidine 235B', Quinolizidine 1-epi-207I, and the Tricyclic 205B are Potent and Selective Noncompetitive Inhibitors of Nicotinic Acetylcholine Receptors
Mol Pharmacol 2004 66: 1061-1069. Published online July 16, 2004; 10.1124/mol.104.000729 [Abstract] [Full Text] [PDF]  

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