Minireview:

Jesse Strock and María A. Diversé-Pierluissi

Ca²⁺ Channels As Integrators of G Protein-Mediated Signaling in Neurons
Mol Pharmacol 2004 66: 1071-1076. Published online July 21, 2004; 10.1124/mol.104.002261 [Abstract] [Full Text] [PDF]  

Perspectives:

Jonathan A. Javitch

The Ants Go Marching Two by Two: Oligomeric Structure of G-Protein-Coupled Receptors
Mol Pharmacol 2004 66: 1077-1082. Published online August 19, 2004; 10.1124/mol.104.006320 [Abstract] [Full Text] [PDF] Related Article  

Articles:

Pieter J. Peeters, Hinrich W. Göhlmann, Ilse Van den Wyngaert, Sigrid M. Swagemakers, Luc Bijnens, Stefan U. Kass, and Thomas Steckler

Transcriptional Response to Corticotropin-Releasing Factor in AtT-20 Cells
Mol Pharmacol 2004 66: 1083-1092. Published online July 22, 2004; 10.1124/mol.104.000950 [Abstract] [Full Text] [PDF] Data Supplement  

Chloé Bellocq, Ronald Wilders, Jean-Jacques Schott, Bénédicte Louérat-Oriou, Pierre Boisseau, Hervé Le Marec, Denis Escande, and Isabelle Baró

A Common Antitussive Drug, Clobutinol, Precipitates the Long QT Syndrome 2
Mol Pharmacol 2004 66: 1093-1102. Published online July 27, 2004; 10.1124/mol.104.001065 [Abstract] [Full Text] [PDF]  

Violeta Visan, Ziad Fajloun, Jean-Marc Sabatier, and Stephan Grissmer

Mapping of Maurotoxin Binding Sites on hKv1.2, hKv1.3, and hIKCa1 Channels
Mol Pharmacol 2004 66: 1103-1112. Published online July 30, 2004; 10.1124/mol.104.002774 [Abstract] [Full Text] [PDF]  

Darryl C. Baptiste, Andrew T. E. Hartwick, Christine A. B. Jollimore, William H. Baldridge, Gail M. Seigel, and Melanie E. M. Kelly

An Investigation of the Neuroprotective Effects of Tetracycline Derivatives in Experimental Models of Retinal Cell Death
Mol Pharmacol 2004 66: 1113-1122. Published online August 10, 2004; 10.1124/mol.104.001081 [Abstract] [Full Text] [PDF]  

Juan J. Carrillo, Juan F. López-Giménez, and Graeme Milligan

Multiple Interactions between Transmembrane Helices Generate the Oligomeric _1b-Adrenoceptor
Mol Pharmacol 2004 66: 1123-1137. Published online August 10, 2004; 10.1124/mol.104.001586 [Abstract] [Full Text] [PDF]  

Carlo Leonetti, Sarah Amodei, Carmen D'Angelo, Angela Rizzo, Barbara Benassi, Anna Antonelli, Raffaella Elli, Malcolm F. G. Stevens, Maurizio D'Incalci, Gabriella Zupi, and Annamaria Biroccio

Biological Activity of the G-Quadruplex Ligand RHPS4 (3,11-Difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate) Is Associated with Telomere Capping Alteration
Mol Pharmacol 2004 66: 1138-1146. Published online August 10, 2004; 10.1124/mol.104.001537 [Abstract] [Full Text] [PDF]  

William A. Sands, Anthony F. Martin, Elaine W. Strong, and Timothy M. Palmer

Specific Inhibition of Nuclear Factor-B–Dependent Inflammatory Responses by Cell Type-Specific Mechanisms upon A_2A Adenosine Receptor Gene Transfer
Mol Pharmacol 2004 66: 1147-1159. Published online July 30, 2004; 10.1124/mol.104.001107 [Abstract] [Full Text] [PDF]  

Hai Wang, Ying-li Zhang, Xing-Chun Tang, Hua-Song Feng, and Gang Hu

Targeting Ischemic Stroke with a Novel Opener of ATP-Sensitive Potassium Channels in the Brain
Mol Pharmacol 2004 66: 1160-1168. Published online August 10, 2004; 10.1124/mol.104.003178 [Abstract] [Full Text] [PDF]  

Gerhard F. Ecker, Karin Pleban, Stephan Kopp, Edina Csaszar, Gerrit J. Poelarends, Monique Putman, Dominik Kaiser, Wil N. Konings, and Peter Chiba

A Three-Dimensional Model for the Substrate Binding Domain of the Multidrug ATP Binding Cassette Transporter LmrA
Mol Pharmacol 2004 66: 1169-1179. Published online August 10, 2004; 10.1124/mol.104.001420 [Abstract] [Full Text] [PDF]  

Sushil K. Mahata, Manjula Mahata, Gen Wen, William B. Wong, Nitish R. Mahapatra, Bruce A. Hamilton, and Daniel T. O'Connor

The Catecholamine Release-Inhibitory "Catestatin" Fragment of Chromogranin A: Naturally Occurring Human Variants with Different Potencies for Multiple Chromaffin Cell Nicotinic Cholinergic Responses
Mol Pharmacol 2004 66: 1180-1191. Published online August 23, 2004; 10.1124/mol.104.002139 [Abstract] [Full Text] [PDF]  

Xinping Lu, Wei Huang, Sharon Worthington, Piotr Drabik, Roman Osman, and Marvin C. Gershengorn

A Model of Inverse Agonist Action at Thyrotropin-Releasing Hormone Receptor Type 1: Role of a Conserved Tryptophan in Helix 6
Mol Pharmacol 2004 66: 1192-1200. Published online August 11, 2004; 10.1124/mol.104.000349 [Abstract] [Full Text] [PDF]  

Harry J. Witchel, Christopher E. Dempsey, Richard B. Sessions, Matthew Perry, James T. Milnes, Jules C. Hancox, and John S. Mitcheson

The Low-Potency, Voltage-Dependent HERG Blocker Propafenone—Molecular Determinants and Drug Trapping
Mol Pharmacol 2004 66: 1201-1212. Published online August 12, 2004; 10.1124/mol.104.001743 [Abstract] [Full Text] [PDF]  

Masakatsu Nanamori, Xiyuan Cheng, Jianghua Mei, Hairong Sang, Yunxia Xuan, Caihong Zhou, Ming-Wei Wang, and Richard D. Ye

A Novel Nonpeptide Ligand for Formyl Peptide Receptor-Like 1
Mol Pharmacol 2004 66: 1213-1222. Published online August 12, 2004; 10.1124/mol.104.004309 [Abstract] [Full Text] [PDF]  

Slobodan M. Todorovic, Sriyani Pathirathna, Barbara C. Brimelow, Miljen M. Jagodic, Seong-Hoon Ko, Xin Jiang, Kent R. Nilsson, Charles F. Zorumski, Douglas F. Covey, and Vesna Jevtovic-Todorovic

5-Reduced Neuroactive Steroids Are Novel Voltage-Dependent Blockers of T-Type Ca²⁺ Channels in Rat Sensory Neurons in Vitro and Potent Peripheral Analgesics in Vivo
Mol Pharmacol 2004 66: 1223-1235. Published online July 27, 2004; 10.1124/mol.104.002402 [Abstract] [Full Text] [PDF]  

Nejmi Dilmac, Nathan Hilliard, and Gregory H. Hockerman

Molecular Determinants of Frequency Dependence and Ca²⁺ Potentiation of Verapamil Block in the Pore Region of Ca_v1.2
Mol Pharmacol 2004 66: 1236-1247. Published online July 30, 2004; 10.1124/mol.104.000893 [Abstract] [Full Text] [PDF]  

Makoto Sugita, Hiroyasu Kongo, and Yoshiki Shiba

Molecular Dissection of the Butyrate Action Revealed the Involvement of Mitogen-Activated Protein Kinase in Cystic Fibrosis Transmembrane Conductance Regulator Biogenesis
Mol Pharmacol 2004 66: 1248-1259. Published online August 10, 2004; 10.1124/mol.104.001008 [Abstract] [Full Text] [PDF]  

Thien P. Dinh, Satish Kathuria, and Daniele Piomelli

RNA Interference Suggests a Primary Role for Monoacylglycerol Lipase in the Degradation of the Endocannabinoid 2-Arachidonoylglycerol
Mol Pharmacol 2004 66: 1260-1264. Published online July 22, 2004; 10.1124/mol.104.002071 [Abstract] [Full Text] [PDF]  

Jianzhong Shen, Cheikh I. Seye, Meifang Wang, Gary A. Weisman, Peter A. Wilden, and Michael Sturek

Cloning, Up-Regulation, and Mitogenic Role of Porcine P2Y₂ Receptor in Coronary Artery Smooth Muscle Cells
Mol Pharmacol 2004 66: 1265-1274. Published online July 27, 2004; 10.1124/mol.104.002642 [Abstract] [Full Text] [PDF]  

Dana E. Selley, Michael P. Cassidy, Billy R. Martin, and Laura J. Sim-Selley

Long-Term Administration of ⁹-Tetrahydrocannabinol Desensitizes CB₁-, Adenosine A₁-, and GABA_B-Mediated Inhibition of Adenylyl Cyclase in Mouse Cerebellum
Mol Pharmacol 2004 66: 1275-1284. Published online July 30, 2004; 10.1124/mol.104.000604 [Abstract] [Full Text] [PDF]  

Wei Guang, Hongyan Wang, Tao Su, I. Bernard Weinstein, and Jia Bei Wang

Role of mPKCI, a Novel µ-Opioid Receptor Interactive Protein, in Receptor Desensitization, Phosphorylation, and Morphine-Induced Analgesia
Mol Pharmacol 2004 66: 1285-1292. [Abstract] [Full Text] [PDF]  

Lisa A. Hazelwood and Elaine Sanders-Bush

His452Tyr Polymorphism in the Human 5-HT_2A Receptor Destabilizes the Signaling Conformation
Mol Pharmacol 2004 66: 1293-1300. [Abstract] [Full Text] [PDF]  

Katherine A. Gould, Cally Nixon, and Michael J. Tilby

p53 Elevation in Relation to Levels and Cytotoxicity of Mono- and Bifunctional Melphalan-DNA Adducts
Mol Pharmacol 2004 66: 1301-1309. Published online August 12, 2004; 10.1124/mol.104.000596 [Abstract] [Full Text] [PDF]  

Tatjana Ignjatovic, Sinisa Stanisavljevic, Viktor Brovkovych, Randal A. Skidgel, and Ervin G. Erdos

Kinin B₁ Receptors Stimulate Nitric Oxide Production in Endothelial Cells: Signaling Pathways Activated by Angiotensin I-Converting Enzyme Inhibitors and Peptide Ligands
Mol Pharmacol 2004 66: 1310-1316. Published online August 10, 2004; 10.1124/mol.104.001990 [Abstract] [Full Text] [PDF]  

Sheng-Ming Wu, Wen-Chih Kuo, Wuh-Liang Hwu, Kuo-Yuan Hwa, Roberto Mantovani, and Yu-May Lee

RNF4 Is a Coactivator for Nuclear Factor Y on GTP Cyclohydrolase I Proximal Promoter
Mol Pharmacol 2004 66: 1317-1324. [Abstract] [Full Text] [PDF]  

Alan C. Embry, Jennifer L. Glick, Maurine E. Linder, and Patrick J. Casey

Reciprocal Signaling between the Transcriptional Co-Factor Eya2 and Specific Members of the Gi Family
Mol Pharmacol 2004 66: 1325-1331. Published online August 12, 2004; 10.1124/mol.104.004093 [Abstract] [Full Text] [PDF]  

Joachim Troost, Heike Lindenmaier, Walter Emil Haefeli, and Johanna Weiss

Modulation of Cellular Cholesterol Alters P-Glycoprotein Activity in Multidrug-Resistant Cells
Mol Pharmacol 2004 66: 1332-1339. Published online August 12, 2004; 10.1124/mol.104.002329 [Abstract] [Full Text] [PDF]  

Chun-Lin Su, Chun-Hung Chen, Hsin-Yi Lu, and Po-Wu Gean

The Involvement of PTEN in Sleep Deprivation-Induced Memory Impairment in Rats
Mol Pharmacol 2004 66: 1340-1348. Published online August 18, 2004; 10.1124/mol.104.001156 [Abstract] [Full Text] [PDF]  

Francisco J. Sánchez-Gómez, Eva Cernuda-Morollón, Konstantinos Stamatakis, and Dolores Pérez-Sala

Protein Thiol Modification by 15-deoxy-^12,14-Prostaglandin J₂ Addition in Mesangial Cells: Role in the Inhibition of Pro-inflammatory Genes
Mol Pharmacol 2004 66: 1349-1358. Published online August 18, 2004; 10.1124/mol.104.002824 [Abstract] [Full Text] [PDF]  

Errata:

Correction to "Maitotoxin induces biphasic interleukin-1 secretion and membrane blebbing in murine macrophages"
Mol Pharmacol 2004 66: 1359. [Full Text] [PDF]  

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