Perspectives:

Delphine Baetz, James Shaw, and Lorrie A. Kirshenbaum

Nuclear Factor-B Decoys Suppress Endotoxin-Induced Lung Injury
Mol Pharmacol 2005 67: 977-979. Published online January 26, 2005; 10.1124/mol.105.011296 [Full Text] [PDF] Related Article  

Lee E. Eiden

Fusion Polypeptides That Inhibit Exocytosis: Fusing Aptamer and Cell-Penetrating Peptide Technologies and Pharmacologies
Mol Pharmacol 2005 67: 980-982. Published online January 26, 2005; 10.1124/mol.105.011429 [Abstract] [Full Text] [PDF] Related Article  

Accelerated Communications:

Maud Deraet, Philippe Manivet, Agnes Janoshazi, Jacques Callebert, Silke Guenther, Ludovic Drouet, Jean-Marie Launay, and Luc Maroteaux

The Natural Mutation Encoding a C Terminus-Truncated 5-Hydroxytryptamine_2B Receptor Is a Gain of Proliferative Functions
Mol Pharmacol 2005 67: 983-991. Published online December 29, 2004; 10.1124/mol.104.008268 [Abstract] [Full Text] [PDF] Data Supplement  

John D. Pediani, Janet F. Colston, Darren Caldwell, Graeme Milligan, Craig J. Daly, and John C. McGrath

-Arrestin-Dependent Spontaneous _1a-Adrenoceptor Endocytosis Causes Intracellular Transportation of -Blockers via Recycling Compartments
Mol Pharmacol 2005 67: 992-1004. Published online December 30, 2004; 10.1124/mol.104.008417 [Abstract] [Full Text] [PDF] Data Supplement  

Roland Baur and Erwin Sigel

Benzodiazepines Affect Channel Opening of GABA_A Receptors Induced by Either Agonist Binding Site
Mol Pharmacol 2005 67: 1005-1008. Published online January 18, 2005; 10.1124/mol.104.008151 [Abstract] [Full Text] [PDF]  

Thomas V. Wuttke, Guiscard Seebohm, Sigrid Bail, Snezana Maljevic, and Holger Lerche

The New Anticonvulsant Retigabine Favors Voltage-Dependent Opening of the K_v7.2 (KCNQ2) Channel by Binding to Its Activation Gate
Mol Pharmacol 2005 67: 1009-1017. Published online January 20, 2005; 10.1124/mol.104.010793 [Abstract] [Full Text] [PDF]  

Articles:

Naoyuki Matsuda, Yuichi Hattori, Subrina Jesmin, and Satoshi Gando

Nuclear Factor-B Decoy Oligodeoxynucleotides Prevent Acute Lung Injury in Mice with Cecal Ligation and Puncture-Induced Sepsis
Mol Pharmacol 2005 67: 1018-1025. Published online December 2, 2004; 10.1124/mol.104.005926 [Abstract] [Full Text] [PDF]  

Christophe Moreau, Fabienne Gally, Heélène Jacquet-Bouix, and Michel Vivaudou

The Size of a Single Residue of the Sulfonylurea Receptor Dictates the Effectiveness of K_ATP Channel Openers
Mol Pharmacol 2005 67: 1026-1033. Published online December 22, 2004; 10.1124/mol.104.008698 [Abstract] [Full Text] [PDF]  

Miklós Bagdáany, Cesar V. F. Batista, Norma A. Valdez-Cruz, Sándor Somodi, Ricardo C. Rodriguez de la Vega, Alexei F. Licea, Zoltáan Varga, Rezso Gáspár, Lourival D. Possani, and György Panyi

Anuroctoxin, a New Scorpion Toxin of the -KTx 6 Subfamily, Is Highly Selective for Kv1.3 over IKCa1 Ion Channels of Human T Lymphocytes
Mol Pharmacol 2005 67: 1034-1044. Published online December 22, 2004; 10.1124/mol.104.007187 [Abstract] [Full Text] [PDF] Data Supplement  

Martijn Bruysters, Aldo Jongejan, Michel Gillard, Frank van de Manakker, Remko A. Bakker, Pierre Chatelain, and Rob Leurs

Pharmacological Differences between Human and Guinea Pig Histamine H₁ Receptors: Asn⁸⁴ (2.61) as Key Residue within an Additional Binding Pocket in the H₁ Receptor
Mol Pharmacol 2005 67: 1045-1052. Published online December 30, 2004; 10.1124/mol.104.008847 [Abstract] [Full Text] [PDF]  

Asher Peretz, Nurit Degani, Rachel Nachman, Yael Uziyel, Gilad Gibor, Doron Shabat, and Bernard Attali

Meclofenamic Acid and Diclofenac, Novel Templates of KCNQ2/Q3 Potassium Channel Openers, Depress Cortical Neuron Activity and Exhibit Anticonvulsant Properties
Mol Pharmacol 2005 67: 1053-1066. Published online December 14, 2004; 10.1124/mol.104.007112 [Abstract] [Full Text] [PDF]  

Wendy M. Suhre, Sean Ekins, Cheng Chang, Peter W. Swaan, and Stephen H. Wright

Molecular Determinants of Substrate/Inhibitor Binding to the Human and Rabbit Renal Organic Cation Transporters hOCT2 and rbOCT2
Mol Pharmacol 2005 67: 1067-1077. Published online January 3, 2005; 10.1124/mol.104.004713 [Abstract] [Full Text] [PDF]  

Zonghe Yan, Zhaodong Liang, Melanija Tomic, Tomas Obsil, and Stanko S. Stojilkovic

Molecular Determinants of the Agonist Binding Domain of a P2X Receptor Channel
Mol Pharmacol 2005 67: 1078-1088. Published online January 4, 2005; 10.1124/mol.104.010108 [Abstract] [Full Text] [PDF]  

Mary A. Bittner and Ronald W. Holz

Phosphatidylinositol-4,5-bisphosphate: Actin Dynamics and the Regulation of ATP-Dependent and -Independent Secretion
Mol Pharmacol 2005 67: 1089-1098. Published online January 5, 2005; 10.1124/mol.104.008474 [Abstract] [Full Text] [PDF]  

Jian Hua Li, Han Choe, Ai Fen Wang, Kaushik Maiti, Chengbing Wang, Abdus Salam, Sang Young Chun, Won-Kyo Lee, Kyungjin Kim, Hyuk Bang Kwon, and Jae Young Seong

Extracellular Loop 3 (EL3) and EL3-Proximal Transmembrane Helix 7 of the Mammalian Type I and Type II Gonadotropin-Releasing Hormone (GnRH) Receptors Determine Differential Ligand Selectivity to GnRH-I and GnRH-II
Mol Pharmacol 2005 67: 1099-1110. Published online January 5, 2005; 10.1124/mol.104.004887 [Abstract] [Full Text] [PDF]  

Rym Barbouche, Hugues Lortat-Jacob, Ian M. Jones, and Emmanuel Fenouillet

Glycosaminoglycans and Protein Disulfide Isomerase-Mediated Reduction of HIV Env
Mol Pharmacol 2005 67: 1111-1118. Published online January 11, 2005; 10.1124/mol.104.008276 [Abstract] [Full Text] [PDF]  

Gang Lu, Dorian Henderson, Lieju Liu, Peter H. Reinhart, and Sidney A. Simon

TRPV1b, a Functional Human Vanilloid Receptor Splice Variant
Mol Pharmacol 2005 67: 1119-1127. Published online January 11, 2005; 10.1124/mol.104.009852 [Abstract] [Full Text] [PDF] Erratum  

Ricardo A. García, Dennis P. Pantazatos, Christopher R. Gessner, Katrina V. Go, Virgil L. Woods, Jr., and Francisco J. Villarreal

Molecular Interactions between Matrilysin and the Matrix Metalloproteinase Inhibitor Doxycycline Investigated by Deuterium Exchange Mass Spectrometry
Mol Pharmacol 2005 67: 1128-1136. Published online January 21, 2005; 10.1124/mol.104.006346 [Abstract] [Full Text] [PDF] Data Supplement  

Kenji Matsushita, Craig N. Morrell, and Charles J. Lowenstein

A Novel Class of Fusion Polypeptides Inhibits Exocytosis
Mol Pharmacol 2005 67: 1137-1144. Published online December 17, 2004; 10.1124/mol.104.004275 [Abstract] [Full Text] [PDF]  

Sanjay Kansra, Stefan W. Stoll, Jessica L. Johnson, and James T. Elder

Src Family Kinase Inhibitors Block Amphiregulin-Mediated Autocrine ErbB Signaling in Normal Human Keratinocytes
Mol Pharmacol 2005 67: 1145-1157. Published online December 22, 2004; 10.1124/mol.104.004689 [Abstract] [Full Text] [PDF]  

S. Rakhit, C. J. Clark, C. T. O'Shaughnessy, and B. J. Morris

N-Methyl-D-aspartate and Brain-Derived Neurotrophic Factor Induce Distinct Profiles of Extracellular Signal-Regulated Kinase, Mitogen- and Stress-Activated Kinase, and Ribosomal S6 Kinase Phosphorylation in Cortical Neurons
Mol Pharmacol 2005 67: 1158-1165. Published online December 29, 2004; 10.1124/mol.104.005447 [Abstract] [Full Text] [PDF]  

Mohamed Rahmani, Erin Reese, Yun Dai, Cheryl Bauer, Lora B. Kramer, Mei Huang, Richard Jove, Paul Dent, and Steven Grant

Cotreatment with Suberanoylanilide Hydroxamic Acid and 17-Allylamino 17-demethoxygeldanamycin Synergistically Induces Apoptosis in Bcr-Abl⁺ Cells Sensitive and Resistant to STI571 (Imatinib Mesylate) in Association with Down-Regulation of Bcr-Abl, Abrogation of Signal Transducer and Activator of Transcription 5 Activity, and Bax Conformational Change
Mol Pharmacol 2005 67: 1166-1176. Published online December 29, 2004; 10.1124/mol.104.007831 [Abstract] [Full Text] [PDF]  

Alatangaole Damirin, Hideaki Tomura, Mayumi Komachi, Masayuki Tobo, Koichi Sato, Chihiro Mogi, Hiromi Nochi, Koichi Tamoto, and Fumikazu Okajima

Sphingosine 1-Phosphate Receptors Mediate the Lipid-Induced cAMP Accumulation through Cyclooxygenase-2/Prostaglandin I₂ Pathway in Human Coronary Artery Smooth Muscle Cells
Mol Pharmacol 2005 67: 1177-1185. Published online December 29, 2004; 10.1124/mol.104.004317 [Abstract] [Full Text] [PDF]  

Jamal Tazi, Nadia Bakkour, Johann Soret, Latifa Zekri, Banasri Hazra, William Laine, Brigitte Baldeyrou, Amélie Lansiaux, and Christian Bailly

Selective Inhibition of Topoisomerase I and Various Steps of Spliceosome Assembly by Diospyrin Derivatives
Mol Pharmacol 2005 67: 1186-1194. Published online December 29, 2004; 10.1124/mol.104.007633 [Abstract] [Full Text] [PDF]  

Eddy H. T. Wu and Yung H. Wong

Involvement of G_i/o Proteins in Nerve Growth Factor-Stimulated Phosphorylation and Degradation of Tuberin in PC-12 Cells and Cortical Neurons
Mol Pharmacol 2005 67: 1195-1205. Published online December 30, 2004; 10.1124/mol.104.007237 [Abstract] [Full Text] [PDF]  

Danièle Lacasa, Nicolas Boute, and Tarik Issad

Interaction of the Insulin Receptor with the Receptor-Like Protein Tyrosine Phosphatases PTP and PTP in Living Cells
Mol Pharmacol 2005 67: 1206-1213. Published online January 3, 2005; 10.1124/mol.104.009514 [Abstract] [Full Text] [PDF]  

Anthony Collins, Haoran Wang, and Maureen K. Larson

Differential Sensitivity of K_ir2 Inward-Rectifier Potassium Channels to a Mitochondrial Uncoupler: Identification of a Regulatory Site
Mol Pharmacol 2005 67: 1214-1220. Published online January 4, 2005; 10.1124/mol.104.008292 [Abstract] [Full Text] [PDF]  

Andrea Barberis, Congyi Lu, Stefano Vicini, and Jerzy W. Mozrzymas

Developmental Changes of GABA Synaptic Transient in Cerebellar Granule Cells
Mol Pharmacol 2005 67: 1221-1228. Published online January 5, 2005; 10.1124/mol.104.006437 [Abstract] [Full Text] [PDF]  

Dacia L. Hunton, William G. Barnes, Jihee Kim, Xiu-Rong Ren, Jonathan D. Violin, Eric Reiter, Graeme Milligan, Dhavalkumar D. Patel, and Robert J. Lefkowitz

-Arrestin 2-Dependent Angiotensin II Type 1A Receptor-Mediated Pathway of Chemotaxis
Mol Pharmacol 2005 67: 1229-1236. Published online January 5, 2005; 10.1124/mol.104.006270 [Abstract] [Full Text] [PDF]  

Marta Enguita, Nuria DeGregorio-Rocasolano, Alba Abad, and Ramon Trullas

Glycogen Synthase Kinase 3 Activity Mediates Neuronal Pentraxin 1 Expression and Cell Death Induced by Potassium Deprivation in Cerebellar Granule Cells
Mol Pharmacol 2005 67: 1237-1246. Published online January 3, 2005; 10.1124/mol.104.007062 [Abstract] [Full Text] [PDF]  

Jessica A. Bonzo, Shujuan Chen, Alema Galijatovic, and Robert H. Tukey

Arsenite Inhibition of CYP1A1 Induction by 2,3,7,8-Tetrachlorodibenzo-p-dioxin Is Independent of Cell Cycle Arrest
Mol Pharmacol 2005 67: 1247-1256. Published online January 3, 2005; 10.1124/mol.104.006130 [Abstract] [Full Text] [PDF]  

Hai-Lin Fang, Stephen C. Strom, Hongbo Cai, Charles N. Falany, Thomas A. Kocarek, and Melissa Runge-Morris

Regulation of Human Hepatic Hydroxysteroid Sulfotransferase Gene Expression by the Peroxisome Proliferator-Activated Receptor Transcription Factor
Mol Pharmacol 2005 67: 1257-1267. Published online January 5, 2005; 10.1124/mol.104.005389 [Abstract] [Full Text] [PDF]  

Christian Watson, Stephen Jenkinson, Wieslaw Kazmierski, and Terry Kenakin

The CCR5 Receptor-Based Mechanism of Action of 873140, a Potent Allosteric Noncompetitive HIV Entry Inhibitor
Mol Pharmacol 2005 67: 1268-1282. Published online January 11, 2005; 10.1124/mol.104.008565 [Abstract] [Full Text] [PDF] Data Supplement  

Mauro Federici, Raffaella Geracitano, Alessandro Tozzi, Patrizia Longone, Silvia Di Angelantonio, C. Peter Bengtson, Giorgio Bernardi, and Nicola B. Mercuri

Trace Amines Depress GABA_B Response in Dopaminergic Neurons by Inhibiting G--Gated Inwardly Rectifying Potassium Channels
Mol Pharmacol 2005 67: 1283-1290. Published online January 11, 2005; 10.1124/mol.104.007427 [Abstract] [Full Text] [PDF]  

Frank Visser, Jing Zhang, R. Taylor Raborn, Stephen A. Baldwin, James D. Young, and Carol E. Cass

Residue 33 of Human Equilibrative Nucleoside Transporter 2 Is a Functionally Important Component of Both the Dipyridamole and Nucleoside Binding Sites
Mol Pharmacol 2005 67: 1291-1298. Published online January 11, 2005; 10.1124/mol.104.005884 [Abstract] [Full Text] [PDF]  

Julien Dairou, François Malecaze, Jean-Marie Dupret, and Fernando Rodrigues-Lima

The Xenobiotic-Metabolizing Enzymes Arylamine N-Acetyltransferases in Human Lens Epithelial Cells: Inactivation by Cellular Oxidants and UVB-Induced Oxidative Stress
Mol Pharmacol 2005 67: 1299-1306. Published online January 11, 2005; 10.1124/mol.104.009738 [Abstract] [Full Text] [PDF]  

Chun-Ling Sun and Chuck C.-K. Chao

Cross-Resistance to Death Ligand-Induced Apoptosis in Cisplatin-Selected HeLa Cells Associated with Overexpression of DDB2 and Subsequent Induction of cFLIP
Mol Pharmacol 2005 67: 1307-1314. Published online January 11, 2005; 10.1124/mol.104.008797 [Abstract] [Full Text] [PDF]  

Laurent Duca, Elise Lambert, Romain Debret, Bernard Rothhut, Charlotte Blanchevoye, Frédéric Delacoux, William Hornebeck, Laurent Martiny, and Laurent Debelle

Elastin Peptides Activate Extracellular Signal-Regulated Kinase 1/2 via a Ras-Independent Mechanism Requiring Both p110/Raf-1 and Protein Kinase A/B-Raf Signaling in Human Skin Fibroblasts
Mol Pharmacol 2005 67: 1315-1324. Published online January 13, 2005; 10.1124/mol.104.002725 [Abstract] [Full Text] [PDF]  

Satu Arpiainen, Françoise Raffalli-Mathieu, Matti A. Lang, Olavi Pelkonen, and Jukka Hakkola

Regulation of the Cyp2a5 Gene Involves an Aryl Hydrocarbon Receptor-Dependent Pathway
Mol Pharmacol 2005 67: 1325-1333. Published online January 18, 2005; 10.1124/mol.104.008078 [Abstract] [Full Text] [PDF]  

Peijin Zhang, Xianbin Tian, Priyamvada Chandra, and Kim L. R. Brouwer

Role of Glycosylation in Trafficking of Mrp2 in Sandwich-Cultured Rat Hepatocytes
Mol Pharmacol 2005 67: 1334-1341. Published online January 20, 2005; 10.1124/mol.104.004481 [Abstract] [Full Text] [PDF]  

Jui-Wen Huang, Chung-Wai Shiau, Ya-Ting Yang, Samuel K. Kulp, Kuen-Feng Chen, Robert W. Brueggemeier, Charles L. Shapiro, and Ching-Shih Chen

Peroxisome Proliferator-Activated Receptor -Independent Ablation of Cyclin D1 by Thiazolidinediones and Their Derivatives in Breast Cancer Cells
Mol Pharmacol 2005 67: 1342-1348. Published online January 13, 2005; 10.1124/mol.104.007732 [Abstract] [Full Text] [PDF]  

Ilan Ifergan, Gerrit Jansen, and Yehuda G. Assaraf

Cytoplasmic Confinement of Breast Cancer Resistance Protein (BCRP/ABCG2) as a Novel Mechanism of Adaptation to Short-Term Folate Deprivation
Mol Pharmacol 2005 67: 1349-1359. Published online January 18, 2005; 10.1124/mol.104.008250 [Abstract] [Full Text] [PDF]  

Kevin R. Hayes, Aaron L. Vollrath, Gina M. Zastrow, Brian J. McMillan, Mark Craven, Stevan Jovanovich, David R. Rank, Sharon Penn, Jacqueline A. Walisser, Janardan K. Reddy, Russell S. Thomas, and Christopher A. Bradfield

EDGE: A Centralized Resource for the Comparison, Analysis, and Distribution of Toxicogenomic Information
Mol Pharmacol 2005 67: 1360-1368. Published online January 20, 2005; 10.1124/mol.104.009175 [Abstract] [Full Text] [PDF]  

Christine Beeton, Michael W. Pennington, Heike Wulff, Satendra Singh, Daniel Nugent, George Crossley, Ilya Khaytin, Peter A. Calabresi, Chao-Yin Chen, George A. Gutman, and K. George Chandy

Targeting Effector Memory T Cells with a Selective Peptide Inhibitor of Kv1.3 Channels for Therapy of Autoimmune Diseases
Mol Pharmacol 2005 67: 1369-1381. Published online January 21, 2005; 10.1124/mol.104.008193 [Abstract] [Full Text] [PDF]  

Errata:

Correction to "Activation of the melastatin-related cation channel TRMP3 by D-erythro-sphingosine"
Mol Pharmacol 2005 67: 1382. [Full Text] [PDF]  

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