Perspectives:

Dianne M. Perez

From Plants to Man: The GPCR "Tree of Life"
Mol Pharmacol 2005 67: 1383-1384. Published online February 9, 2005; 10.1124/mol.105.011890 [Abstract] [Full Text] [PDF] Related Article  

Joel Linden

Adenosine in Tissue Protection and Tissue Regeneration
Mol Pharmacol 2005 67: 1385-1387. Published online February 9, 2005; 10.1124/mol.105.011783 [Abstract] [Full Text] [PDF] Related Article  

JoAnn Trejo

Internal PDZ Ligands: Novel Endocytic Recycling Motifs for G Protein-Coupled Receptors
Mol Pharmacol 2005 67: 1388-1390. Published online February 15, 2005; 10.1124/mol.105.011288 [Abstract] [Full Text] [PDF] Related Article  

Gerhard Burckhardt

Polyspecific Organic Cation Transport: Insights into the Substrate Binding Site
Mol Pharmacol 2005 67: 1391-1392. Published online February 25, 2005; 10.1124/mol.105.012161 [Abstract] [Full Text] [PDF] Related Articles  

Accelerated Communications:

Kalyan Pande, Susan M. Moran, and Christopher A. Bradfield

Aspects of Dioxin Toxicity Are Mediated by Interleukin 1-Like Cytokines
Mol Pharmacol 2005 67: 1393-1398. Published online February 18, 2005; 10.1124/mol.105.010983 [Abstract] [Full Text] [PDF]  

Orazio Cantoni, Andrea Guidarelli, Letizia Palomba, and Mara Fiorani

U937 Cell Necrosis Mediated by Peroxynitrite Is Not Caused by Depletion of ATP and Is Prevented by Arachidonate via an ATP-Dependent Mechanism
Mol Pharmacol 2005 67: 1399-1405. Published online February 2, 2005; 10.1124/mol.104.009498 [Abstract] [Full Text] [PDF]  

Articles:

Avani Desai, Cassandre Victor-Vega, Swathi Gadangi, M. Carmen Montesinos, Charles C. Chu, and Bruce N. Cronstein

Adenosine A_2A Receptor Stimulation Increases Angiogenesis by Down-Regulating Production of the Antiangiogenic Matrix Protein Thrombospondin 1
Mol Pharmacol 2005 67: 1406-1413. Published online January 26, 2005; 10.1124/mol.104.007807 [Abstract] [Full Text] [PDF]  

Robert Fredriksson and Helgi B. Schiöth

The Repertoire of G-Protein–Coupled Receptors in Fully Sequenced Genomes
Mol Pharmacol 2005 67: 1414-1425. Published online February 1, 2005; 10.1124/mol.104.009001 [Abstract] [Full Text] [PDF] Data Supplement  

B. J. Eickholt, G. J. Towers, W. J. Ryves, D. Eikel, K. Adley, L. M. J. Ylinen, N. H. Chadborn, A. J. Harwood, H. Nau, and R. S. B. Williams

Effects of Valproic Acid Derivatives on Inositol Trisphosphate Depletion, Teratogenicity, Glycogen Synthase Kinase-3 Inhibition, and Viral Replication: A Screening Approach for New Bipolar Disorder Drugs Derived from the Valproic Acid Core Structure
Mol Pharmacol 2005 67: 1426-1433. Published online February 1, 2005; 10.1124/mol.104.009308 [Abstract] [Full Text] [PDF]  

Evgeni Ponimaskin, Aline Dumuis, Florence Gaven, Gaël Barthet, Martin Heine, Konstantin Glebov, Diethelm W. Richter, and Martin Oppermann

Palmitoylation of the 5-Hydroxytryptamine_4a Receptor Regulates Receptor Phosphorylation, Desensitization, and -Arrestin-Mediated Endocytosis
Mol Pharmacol 2005 67: 1434-1443. Published online February 2, 2005; 10.1124/mol.104.008748 [Abstract] [Full Text] [PDF]  

Xiao-Feng Zhu, Bin-Fen Xie, Jun-Min Zhou, Gong-Kan Feng, Zong-Chao Liu, Xiao-Yi Wei, Feng-Xian Zhang, Mei-Fang Liu, and Yi-Xin Zeng

Blockade of Vascular Endothelial Growth Factor Receptor Signal Pathway and Antitumor Activity of ON-III (2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone), a Component from Chinese Herbal Medicine
Mol Pharmacol 2005 67: 1444-1450. Published online February 9, 2005; 10.1124/mol.104.009894 [Abstract] [Full Text] [PDF]  

Mirella Belleri, Domenico Ribatti, Stefania Nicoli, Franco Cotelli, Luca Forti, Vanio Vannini, Lucia Anna Stivala, and Marco Presta

Antiangiogenic and Vascular-Targeting Activity of the Microtubule-Destabilizing trans-Resveratrol Derivative 3,5,4'-Trimethoxystilbene
Mol Pharmacol 2005 67: 1451-1459. Published online February 9, 2005; 10.1124/mol.104.009043 [Abstract] [Full Text] [PDF] Data Supplement  

Mingxiang Liao, Victor G. Zgoda, Bernard P. Murray, and Maria Almira Correia

Vacuolar Degradation of Rat Liver CYP2B1 in Saccharomyces cerevisiae: Further Validation of the Yeast Model and Structural Implications for the Degradation of Mammalian Endoplasmic Reticulum P450 Proteins
Mol Pharmacol 2005 67: 1460-1469. Published online February 9, 2005; 10.1124/mol.104.009654 [Abstract] [Full Text] [PDF] Erratum  

Philip E. Chen, Matthew T. Geballe, Phillip J. Stansfeld, Alexander R. Johnston, Hongjie Yuan, Amanda L. Jacob, James P. Snyder, Stephen F. Traynelis, and David J. A. Wyllie

Structural Features of the Glutamate Binding Site in Recombinant NR1/NR2A N-Methyl-D-aspartate Receptors Determined by Site-Directed Mutagenesis and Molecular Modeling
Mol Pharmacol 2005 67: 1470-1484. Published online February 9, 2005; 10.1124/mol.104.008185 [Abstract] [Full Text] [PDF]  

F. Boudsocq, P. Benaim, Y. Canitrot, M. Knibiehler, F. Ausseil, J. P. Capp, A. Bieth, C. Long, B. David, I. Shevelev, E. Frierich-Heinecken, U. Hübscher, F. Amalric, G. Massiot, J. S. Hoffmann, and C. Cazaux

Modulation of Cellular Response to Cisplatin by a Novel Inhibitor of DNA Polymerase
Mol Pharmacol 2005 67: 1485-1492. Published online February 9, 2005; 10.1124/mol.104.001776 [Abstract] [Full Text] [PDF]  

John A. Allen, Jiang Z. Yu, Robert J. Donati, and Mark M. Rasenick

-Adrenergic Receptor Stimulation Promotes Gs Internalization through Lipid Rafts: A Study in Living Cells
Mol Pharmacol 2005 67: 1493-1504. Published online February 9, 2005; 10.1124/mol.104.008342 [Abstract] [Full Text] [PDF] Data Supplement  

Henry A. Charlier, Jr., Richard D. Olson, Carissa M. Thornock, Wendy K. Mercer, David R. Olson, T. Stephen Broyles, Dawn J. Muhlestein, Corianton L. Larson, Barry J. Cusack, and Susan E. Shadle

Investigations of Calsequestrin as a Target for Anthracyclines: Comparison of Functional Effects of Daunorubicin, Daunorubicinol, and Trifluoperazine
Mol Pharmacol 2005 67: 1505-1512. Published online February 10, 2005; 10.1124/mol.104.005728 [Abstract] [Full Text] [PDF]  

Lizhen Yan, James Herrington, Ethan Goldberg, Paula M. Dulski, Randal M. Bugianesi, Robert S. Slaughter, Priya Banerjee, Richard M. Brochu, Birgit T. Priest, Gregory J. Kaczorowski, Bernardo Rudy, and Maria L. Garcia

Stichodactyla helianthus Peptide, a Pharmacological Tool for Studying Kv3.2 Channels
Mol Pharmacol 2005 67: 1513-1521. Published online February 11, 2005; 10.1124/mol.105.011064 [Abstract] [Full Text] [PDF]  

Yueming Huang and Zhiyi Zuo

Isoflurane Induces a Protein Kinase C -Dependent Increase in Cell-Surface Protein Level and Activity of Glutamate Transporter Type 3
Mol Pharmacol 2005 67: 1522-1533. Published online February 11, 2005; 10.1124/mol.104.007443 [Abstract] [Full Text] [PDF]  

Sun-Young Chang, Hyun-Jeong Ko, Tae-Hwe Heo, and Chang-Yuil Kang

Heparan Sulfate Regulates the Antiangiogenic Activity of Endothelial Monocyte-Activating Polypeptide-II at Acidic pH
Mol Pharmacol 2005 67: 1534-1543. Published online February 14, 2005; 10.1124/mol.104.008532 [Abstract] [Full Text] [PDF]  

T. Fahrig, I. Gerlach, and E. Horváth

A Synthetic Derivative of the Natural Product Rocaglaol Is a Potent Inhibitor of Cytokine-Mediated Signaling and Shows Neuroprotective Activity in Vitro and in Animal Models of Parkinson's Disease and Traumatic Brain Injury
Mol Pharmacol 2005 67: 1544-1555. Published online February 16, 2005; 10.1124/mol.104.008177 [Abstract] [Full Text] [PDF]  

Jan Balzarini, Kristel Van Laethem, Sigrid Hatse, Matheus Froeyen, Els Van Damme, Anders Bolmstedt, Willy Peumans, Erik De Clercq, and Dominique Schols

Marked Depletion of Glycosylation Sites in HIV-1 gp120 under Selection Pressure by the Mannose-Specific Plant Lectins of Hippeastrum Hybrid and Galanthus nivalis
Mol Pharmacol 2005 67: 1556-1565. Published online February 17, 2005; 10.1124/mol.104.005082 [Abstract] [Full Text] [PDF]  

Guy Eelen, Lieve Verlinden, Natacha Rochel, Frank Claessens, Pierre De Clercq, Maurits Vandewalle, Giuseppe Tocchini-Valentini, Dino Moras, Roger Bouillon, and Annemieke Verstuyf

Superagonistic Action of 14-epi-Analogs of 1,25-Dihydroxyvitamin D Explained by Vitamin D Receptor-Coactivator Interaction
Mol Pharmacol 2005 67: 1566-1573. Published online February 22, 2005; 10.1124/mol.104.008730 [Abstract] [Full Text] [PDF]  

Dirk Daelemans, Christophe Pannecouque, George N. Pavlakis, Oriana Tabarrini, and Erik De Clercq

A Novel and Efficient Approach to Discriminate between Pre- and Post-Transcription HIV Inhibitors
Mol Pharmacol 2005 67: 1574-1580. Published online February 23, 2005; 10.1124/mol.104.010249 [Abstract] [Full Text] [PDF]  

Joachim D. Paasche, Toril Attramadal, Kurt Kristiansen, Morten P. Oksvold, Heidi K. Johansen, Henrik S. Huitfeldt, Svein G. Dahl, and Håvard Attramadal

Subtype-Specific Sorting of the ET_A Endothelin Receptor by a Novel Endocytic Recycling Signal for G Protein-Coupled Receptors
Mol Pharmacol 2005 67: 1581-1590. Published online February 15, 2005; 10.1124/mol.104.007013 [Abstract] [Full Text] [PDF]  

Hugh C. Hemmings, Jr., Wayne Yan, Robert I. Westphalen, and Timothy A. Ryan

The General Anesthetic Isoflurane Depresses Synaptic Vesicle Exocytosis
Mol Pharmacol 2005 67: 1591-1599. Published online February 22, 2005; 10.1124/mol.104.003210 [Abstract] [Full Text] [PDF]  

Christian Popp, Valentin Gorboulev, Thomas D. Müller, Dmitry Gorbunov, Natalia Shatskaya, and Hermann Koepsell

Amino Acids Critical for Substrate Affinity of Rat Organic Cation Transporter 1 Line the Substrate Binding Region in a Model Derived from the Tertiary Structure of Lactose Permease
Mol Pharmacol 2005 67: 1600-1611. Published online January 20, 2005; 10.1124/mol.104.008839 [Abstract] [Full Text] [PDF]  

Valentin Gorboulev, Natalia Shatskaya, Christopher Volk, and Hermann Koepsell

Subtype-Specific Affinity for Corticosterone of Rat Organic Cation Transporters rOCT1 and rOCT2 Depends on Three Amino Acids within the Substrate Binding Region
Mol Pharmacol 2005 67: 1612-1619. Published online January 20, 2005; 10.1124/mol.104.008821 [Abstract] [Full Text] [PDF]  

Armando Ialenti, Gianluca Grassia, Paola Di Meglio, Pasquale Maffia, Massimo Di Rosa, and Angela Ianaro

Mechanism of the Anti-Inflammatory Effect of Thiazolidinediones: Relationship with the Glucocorticoid Pathway
Mol Pharmacol 2005 67: 1620-1628. Published online January 31, 2005; 10.1124/mol.104.004895 [Abstract] [Full Text] [PDF]  

Katrin Popowski, Jyrki J. Eloranta, Michael Saborowski, Michael Fried, Peter J. Meier, and Gerd A. Kullak-Ublick

The Human Organic Anion Transporter 2 Gene Is Transactivated by Hepatocyte Nuclear Factor-4 and Suppressed by Bile Acids
Mol Pharmacol 2005 67: 1629-1638. Published online February 3, 2005; 10.1124/mol.104.010223 [Abstract] [Full Text] [PDF]  

Albert Lai, Neeraja Parameswaran, Mirium Khwaja, Paul Whiteaker, Jon M. Lindstrom, Hong Fan, J. Michael McIntosh, Sharon R. Grady, and Maryka Quik

Long-Term Nicotine Treatment Decreases Striatal 6* Nicotinic Acetylcholine Receptor Sites and Function in Mice
Mol Pharmacol 2005 67: 1639-1647. Published online January 28, 2005; 10.1124/mol.104.006429 [Abstract] [Full Text] [PDF]  

V. Yarotskyy, A. V. Glushakov, C. Sumners, N. Gravenstein, D. M. Dennis, C. N. Seubert, and A. E. Martynyuk

Differential Modulation of Glutamatergic Transmission by 3,5-Dibromo-L-phenylalanine
Mol Pharmacol 2005 67: 1648-1654. Published online February 1, 2005; 10.1124/mol.104.005983 [Abstract] [Full Text] [PDF]  

Debbie L. Hay, George Christopoulos, Arthur Christopoulos, David R. Poyner, and Patrick M. Sexton

Pharmacological Discrimination of Calcitonin Receptor: Receptor Activity-Modifying Protein Complexes
Mol Pharmacol 2005 67: 1655-1665. Published online February 3, 2005; 10.1124/mol.104.008615 [Abstract] [Full Text] [PDF]  

Jian-Mei Li, Masaru Iwai, Tai-Xing Cui, Li-Juan Min, Masahiro Tsuda, Jun Iwanami, Jun Suzuki, Masaki Mogi, and Masatsugu Horiuchi

Effect of Azelnidipine on Angiotensin II-Mediated Growth-Promoting Signaling in Vascular Smooth Muscle Cells
Mol Pharmacol 2005 67: 1666-1673. Published online February 4, 2005; 10.1124/mol.104.008144 [Abstract] [Full Text] [PDF]  

Hack Sun Choi, Cheol Kyu Hwang, Chun Sung Kim, Kyu Young Song, Ping-Yee Law, Li-Na Wei, and Horace H. Loh

Transcriptional Regulation of Mouse µ Opioid Receptor Gene: Sp3 Isoforms (M1, M2) Function as Repressors in Neuronal Cells to Regulate the µ Opioid Receptor Gene
Mol Pharmacol 2005 67: 1674-1683. Published online February 9, 2005; 10.1124/mol.104.008284 [Abstract] [Full Text] [PDF]  

Irina M. Müller, Verena M. Dirsch, Anita Rudy, Nancy López-Antón, George R. Pettit, and Angelika M. Vollmar

Cephalostatin 1 Inactivates Bcl-2 by Hyperphosphorylation Independent of M-Phase Arrest and DNA Damage
Mol Pharmacol 2005 67: 1684-1689. Published online February 9, 2005; 10.1124/mol.104.004234 [Abstract] [Full Text] [PDF]  

Ashley E. Brady, Qin Wang, Patrick B. Allen, Mark Rizzo, Paul Greengard, and Lee E. Limbird

2-Adrenergic Agonist Enrichment of Spinophilin at the Cell Surface Involves Subunits of G_i Proteins and Is Preferentially Induced by the _2A-Subtype
Mol Pharmacol 2005 67: 1690-1696. Published online February 10, 2005; 10.1124/mol.104.005215 [Abstract] [Full Text] [PDF]  

Christopher S. Kearn, Katherine Blake-Palmer, Emma Daniel, Ken Mackie, and Michelle Glass

Concurrent Stimulation of Cannabinoid CB1 and Dopamine D2 Receptors Enhances Heterodimer Formation: A Mechanism for Receptor Cross-Talk?
Mol Pharmacol 2005 67: 1697-1704. Published online February 14, 2005; 10.1124/mol.104.006882 [Abstract] [Full Text] [PDF]  

Samantha J. Pitt, Juan Martinez-Pinna, Eric A. Barnard, and Martyn P. Mahaut-Smith

Potentiation of P2Y Receptors by Physiological Elevations of Extracellular K⁺ via a Mechanism Independent of Ca²⁺ Influx
Mol Pharmacol 2005 67: 1705-1713. Published online February 14, 2005; 10.1124/mol.104.009902 [Abstract] [Full Text] [PDF]  

Jérôme Fagart, Cendrine Seguin, Grégory Maurice Pinon, and Marie-Edith Rafestin-Oblin

The Met852 Residue Is a Key Organizer of the Ligand-Binding Cavity of the Human Mineralocorticoid Receptor
Mol Pharmacol 2005 67: 1714-1722. Published online February 16, 2005; 10.1124/mol.104.010710 [Abstract] [Full Text] [PDF]  

Guanghua Tang, Lingyun Wu, and Rui Wang

The Effect of Hydroxylamine on K_ATP Channels in Vascular Smooth Muscle and Underlying Mechanisms
Mol Pharmacol 2005 67: 1723-1731. Published online February 16, 2005; 10.1124/mol.104.008953 [Abstract] [Full Text] [PDF]  

Tim O. Lankisch, Arndt Vogel, Stefan Eilermann, Anette Fiebeler, Britta Krone, Ayse Barut, Michael P. Manns, and Christian P. Strassburg

Identification and Characterization of a Functional TATA Box Polymorphism of the UDP Glucuronosyltransferase 1A7 Gene
Mol Pharmacol 2005 67: 1732-1739. Published online February 16, 2005; 10.1124/mol.104.007146 [Abstract] [Full Text] [PDF]  

Lenka L. Allan and David H. Sherr

Constitutive Activation and Environmental Chemical Induction of the Aryl Hydrocarbon Receptor/Transcription Factor in Activated Human B Lymphocytes
Mol Pharmacol 2005 67: 1740-1750. Published online January 28, 2005; 10.1124/mol.104.009100 [Abstract] [Full Text] [PDF]  

Christian Feißt, Dana Albert, Dieter Steinhilber, and Oliver Werz

The Aminosteroid Phospholipase C Antagonist U-73122 (1-[6-[[17--3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione) Potently Inhibits Human 5-Lipoxygenase in Vivo and in Vitro
Mol Pharmacol 2005 67: 1751-1757. Published online January 31, 2005; 10.1124/mol.105.011007 [Abstract] [Full Text] [PDF]  

Gracia Merino, Johan W. Jonker, Els Wagenaar, Antonius E. van Herwaarden, and Alfred H. Schinkel

The Breast Cancer Resistance Protein (BCRP/ABCG2) Affects Pharmacokinetics, Hepatobiliary Excretion, and Milk Secretion of the Antibiotic Nitrofurantoin
Mol Pharmacol 2005 67: 1758-1764. Published online February 11, 2005; 10.1124/mol.104.010439 [Abstract] [Full Text] [PDF]  

Gracia Merino, Antonius E. van Herwaarden, Els Wagenaar, Johan W. Jonker, and Alfred H. Schinkel

Sex-Dependent Expression and Activity of the ATP-Binding Cassette Transporter Breast Cancer Resistance Protein (BCRP/ABCG2) in Liver
Mol Pharmacol 2005 67: 1765-1771. Published online February 18, 2005; 10.1124/mol.105.011080 [Abstract] [Full Text] [PDF]  

Jörg Zukunft, Thomas Lang, Tanja Richter, Karen I. Hirsch-Ernst, Andreas K. Nussler, Kathrin Klein, Matthias Schwab, Michel Eichelbaum, and Ulrich M. Zanger

A Natural CYP2B6 TATA Box Polymorphism (–82T C) Leading to Enhanced Transcription and Relocation of the Transcriptional Start Site
Mol Pharmacol 2005 67: 1772-1782. Published online February 18, 2005; 10.1124/mol.104.008086 [Abstract] [Full Text] [PDF]  

Jean-Marie Mangin, Laurent Nguyen, Catherine Gougnard, Grégory Hans, Bernard Rogister, Shibeshih Belachew, Gustave Moonen, Pascal Legendre, and Jean-Michel Rigo

Developmental Regulation of -Carboline-Induced Inhibition of Glycine-Evoked Responses Depends on Glycine Receptor Subunit Expression
Mol Pharmacol 2005 67: 1783-1796. Published online February 18, 2005; 10.1124/mol.104.007435 [Abstract] [Full Text] [PDF]  

Nicoletta Pedemonte, N. D. Sonawane, Alessandro Taddei, Jie Hu, Olga Zegarra-Moran, Yat Fan Suen, Lori I. Robins, Christopher W. Dicus, Dan Willenbring, Michael H. Nantz, Mark J. Kurth, Luis J. V. Galietta, and A. S. Verkman

Phenylglycine and Sulfonamide Correctors of Defective F508 and G551D Cystic Fibrosis Transmembrane Conductance Regulator Chloride-Channel Gating
Mol Pharmacol 2005 67: 1797-1807. Published online February 18, 2005; 10.1124/mol.105.010959 [Abstract] [Full Text] [PDF] Data Supplement  

Makoto Osanai and Martin Petkovich

Expression of the Retinoic Acid-Metabolizing Enzyme CYP26A1 Limits Programmed Cell Death
Mol Pharmacol 2005 67: 1808-1817. Published online February 9, 2005; 10.1124/mol.104.005769 [Abstract] [Full Text] [PDF]  

Errata:

Correction to "TRPV1b, a Functional Human Vanilloid Receptor Splice Variant"
Mol Pharmacol 2005 67: 1818. [Full Text] [PDF]  

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