Minireview:

Milin R. Acharya, Alex Sparreboom, Jürgen Venitz, and William D. Figg

Rational Development of Histone Deacetylase Inhibitors as Anticancer Agents: A Review
Mol Pharmacol 2005 68: 917-932. Published online June 14, 2005; 10.1124/mol.105.014167 [Abstract] [Full Text] [PDF]  

Olivia S. Gardner, Brian J. Dewar, and Lee M. Graves

Activation of Mitogen-Activated Protein Kinases by Peroxisome Proliferator-Activated Receptor Ligands: An Example of Nongenomic Signaling
Mol Pharmacol 2005 68: 933-941. Published online July 14, 2005; 10.1124/mol.105.012260 [Abstract] [Full Text] [PDF]  

Steven David Buckingham, Philip Charles Biggin, Benedict Mark Sattelle, Laurence Andrew Brown, and David Barry Sattelle

Insect GABA Receptors: Splicing, Editing, and Targeting by Antiparasitics and Insecticides
Mol Pharmacol 2005 68: 942-951. Published online July 18, 2005; 10.1124/mol.105.015313 [Abstract] [Full Text] [PDF]  

Perspectives:

Katerina Akassoglou

Nerve Growth Factor-Independent Neuronal Survival: A Role for NO Donors
Mol Pharmacol 2005 68: 952-955. Published online July 26, 2005; 10.1124/mol.105.017277 [Abstract] [Full Text] [PDF] Related Article  

Thomas P. Burris and Venkatesh Krishnan

Estrogen: A Mitochrondrial Energizer That Keeps on Going
Mol Pharmacol 2005 68: 956-958. Published online July 28, 2005; 10.1124/mol.105.017335 [Abstract] [Full Text] [PDF] Related Article  

Articles:

Chris Stirone, Sue P. Duckles, Diana N. Krause, and Vincent Procaccio

Estrogen Increases Mitochondrial Efficiency and Reduces Oxidative Stress in Cerebral Blood Vessels
Mol Pharmacol 2005 68: 959-965. Published online June 30, 2005; 10.1124/mol.105.014662 [Abstract] [Full Text] [PDF]  

Tobias Dreker and Stephan Grissmer

Investigation of the Phenylalkylamine Binding Site in hKv1.3 (H399T), a Mutant with a Reduced C-Type Inactivated State
Mol Pharmacol 2005 68: 966-973. Published online July 6, 2005; 10.1124/mol.105.012401 [Abstract] [Full Text] [PDF]  

John Dunlop, H. Beal McIlvain, Tikva A. Carrick, Brian Jow, Qiang Lu, Dianne Kowal, Steven Lin, Alexander Greenfield, Cristina Grosanu, Kristi Fan, Robert Petroski, John Williams, Alan Foster, and John Butera

Characterization of Novel Aryl-Ether, Biaryl, and Fluorene Aspartic Acid and Diaminopropionic Acid Analogs as Potent Inhibitors of the High-Affinity Glutamate Transporter EAAT2
Mol Pharmacol 2005 68: 974-982. Published online July 13, 2005; 10.1124/mol.105.012005 [Abstract] [Full Text] [PDF]  

Hua-Rui Lu, Hong Zhu, Min Huang, Yi Chen, Yu-Jun Cai, Ze-Hong Miao, Jin-Sheng Zhang, and Jian Ding

Reactive Oxygen Species Elicit Apoptosis by Concurrently Disrupting Topoisomerase II and DNA-Dependent Protein Kinase
Mol Pharmacol 2005 68: 983-994. Published online July 15, 2005; 10.1124/mol.105.011544 [Abstract] [Full Text] [PDF]  

Niels Decher, Pradeep Kumar, Teresa Gonzalez, Vijay Renigunta, and Michael C. Sanguinetti

Structural Basis for Competition between Drug Binding and Kv1.3 Accessory Subunit-Induced N-Type Inactivation of Kv1.5 Channels
Mol Pharmacol 2005 68: 995-1005. Published online July 15, 2005; 10.1124/mol.105.011668 [Abstract] [Full Text] [PDF]  

Carsten Culmsee, Norbert Gerling, Stefan Landshamer, Bianca Rickerts, Hans-Jürgen Duchstein, Kazuo Umezawa, Susanne Klumpp, and Josef Krieglstein

Nitric Oxide Donors Induce Neurotrophin-Like Survival Signaling and Protect Neurons against Apoptosis
Mol Pharmacol 2005 68: 1006-1017. Published online July 18, 2005; 10.1124/mol.105.013086 [Abstract] [Full Text] [PDF]  

Won Jun Lee, Joong-Youn Shim, and Bao Ting Zhu

Mechanisms for the Inhibition of DNA Methyltransferases by Tea Catechins and Bioflavonoids
Mol Pharmacol 2005 68: 1018-1030. Published online July 21, 2005; 10.1124/mol.104.008367 [Abstract] [Full Text] [PDF]  

Kathrin Kopplow, Katrin Letschert, Jörg König, Bettina Walter, and Dietrich Keppler

Human Hepatobiliary Transport of Organic Anions Analyzed by Quadruple-Transfected Cells
Mol Pharmacol 2005 68: 1031-1038. Published online July 26, 2005; 10.1124/mol.105.014605 [Abstract] [Full Text] [PDF]  

Jessica P. Ryman-Rasmussen, David E. Nichols, and Richard B. Mailman

Differential Activation of Adenylate Cyclase and Receptor Internalization by Novel Dopamine D₁ Receptor Agonists
Mol Pharmacol 2005 68: 1039-1048. Published online June 28, 2005; 10.1124/mol.105.012153 [Abstract] [Full Text] [PDF]  

Dillon I. Beardsley, Wan-Ju Kim, and Kevin D. Brown

N-Methyl-N'-nitro-N-nitrosoguanidine Activates Cell-Cycle Arrest through Distinct Mechanisms Activated in a Dose-Dependent Manner
Mol Pharmacol 2005 68: 1049-1060. Published online June 30, 2005; 10.1124/mol.105.013888 [Abstract] [Full Text] [PDF]  

Men Luh Yen, Jen Liang Su, Chung Liang Chien, Kuang Wen Tseng, Ching Yao Yang, Wei Fang Chen, Chiao Chia Chang, and Min Liang Kuo

Diosgenin Induces Hypoxia-Inducible Factor-1 Activation and Angiogenesis through Estrogen Receptor-Related Phosphatidylinositol 3-kinase/Akt and p38 Mitogen-Activated Protein Kinase Pathways in Osteoblasts
Mol Pharmacol 2005 68: 1061-1073. Published online July 5, 2005; 10.1124/mol.104.010082 [Abstract] [Full Text] [PDF]  

Gi-Wook Hwang, Daisuke Sasaki, and Akira Naganuma

Overexpression of Rad23 Confers Resistance to Methylmercury in Saccharomyces cerevisiae via Inhibition of the Degradation of Ubiquitinated Proteins
Mol Pharmacol 2005 68: 1074-1078. Published online July 5, 2005; 10.1124/mol.105.013516 [Abstract] [Full Text] [PDF]  

Zhihua Xie, Rashmi G. Bhushan, David J. Daniels, and Philip S. Portoghese

Interaction of Bivalent Ligand KDN21 with Heterodimeric - Opioid Receptors in Human Embryonic Kidney 293 Cells
Mol Pharmacol 2005 68: 1079-1086. Published online July 8, 2005; 10.1124/mol.105.012070 [Abstract] [Full Text] [PDF]  

Heui-Young Ryu, Jessica K. Emberley, Jennifer J. Schlezinger, Lenka L. Allan, Songqing Na, and David H. Sherr

Environmental Chemical-Induced Bone Marrow B Cell Apoptosis: Death Receptor-Independent Activation of a Caspase-3 to Caspase-8 Pathway
Mol Pharmacol 2005 68: 1087-1096. Published online July 12, 2005; 10.1124/mol.105.014712 [Abstract] [Full Text] [PDF]  

Henrike Heissig, Karin A. Urban, Katja Hastedt, Bernd J. Zünkler, and Uwe Panten

Mechanism of the Insulin-Releasing Action of -Ketoisocaproate and Related -Keto Acid Anions
Mol Pharmacol 2005 68: 1097-1105. Published online July 13, 2005; 10.1124/mol.105.015388 [Abstract] [Full Text] [PDF]  

Romy Frenzel, Knut Krohn, Markus Eszlinger, Anke Tönjes, and Ralf Paschke

Sialylation of Human Thyrotropin Receptor Improves and Prolongs Its Cell-Surface Expression
Mol Pharmacol 2005 68: 1106-1113. Published online July 13, 2005; 10.1124/mol.105.012906 [Abstract] [Full Text] [PDF]  

Jun-Ho Lee, Sang Min Jeong, Jong-Hoon Kim, Byung-Hwan Lee, In-Soo Yoon, Joon-Hee Lee, Sun-Hye Choi, Dong-Hyun Kim, Hyewhon Rhim, Sung Soo Kim, Jai-Il Kim, Choon-Gon Jang, Jin-Ho Song, and Seung-Yeol Nah

Characteristics of Ginsenoside Rg₃-Mediated Brain Na⁺ Current Inhibition
Mol Pharmacol 2005 68: 1114-1126. Published online July 13, 2005; 10.1124/mol.105.015115 [Abstract] [Full Text] [PDF]  

Vu C. Dang and John T. Williams

Morphine-Induced µ-Opioid Receptor Desensitization
Mol Pharmacol 2005 68: 1127-1132. Published online July 14, 2005; 10.1124/mol.105.013185 [Abstract] [Full Text] [PDF]  

Andreas Papapetropoulos, Zongmin Zhou, Christina Gerassimou, Gunay Yetik, Richard C. Venema, Charis Roussos, William C. Sessa, and John D. Catravas

Interaction between the 90-kDa Heat Shock Protein and Soluble Guanylyl Cyclase: Physiological Significance and Mapping of the Domains Mediating Binding
Mol Pharmacol 2005 68: 1133-1141. Published online July 15, 2005; 10.1124/mol.105.012682 [Abstract] [Full Text] [PDF] Data Supplement  

Hisao Yamamura, Shinya Ugawa, Takashi Ueda, Masataka Nagao, and Shoichi Shimada

Icilin Activates the -Subunit of the Human Epithelial Na⁺ Channel
Mol Pharmacol 2005 68: 1142-1147. Published online July 20, 2005; 10.1124/mol.104.010850 [Abstract] [Full Text] [PDF]  

Gabriela Popescu

Principles of N-Methyl-D-aspartate Receptor Allosteric Modulation
Mol Pharmacol 2005 68: 1148-1155. Published online July 20, 2005; 10.1124/mol.105.013896 [Abstract] [Full Text] [PDF]  

Hironori Ushijima, Ken-Ichiiro Tanaka, Miho Takeda, Takashi Katsu, Shinji Mima, and Tohru Mizushima

Geranylgeranylacetone Protects Membranes against Nonsteroidal Anti-Inflammatory Drugs
Mol Pharmacol 2005 68: 1156-1161. Published online July 26, 2005; 10.1124/mol.105.015784 [Abstract] [Full Text] [PDF]  

Cecilia Gotti, Milena Moretti, Alessio Zanardi, Annalisa Gaimarri, Nicolas Champtiaux, Jean-Pierre Changeux, Paul Whiteaker, Michael J. Marks, Francesco Clementi, and Michele Zoli

Heterogeneity and Selective Targeting of Neuronal Nicotinic Acetylcholine Receptor (nAChR) Subtypes Expressed on Retinal Afferents of the Superior Colliculus and Lateral Geniculate Nucleus: Identification of a New Native nAChR Subtype 32(5 or 3) Enriched in Retinocollicular Afferents
Mol Pharmacol 2005 68: 1162-1171. Published online July 27, 2005; 10.1124/mol.105.015925 [Abstract] [Full Text] [PDF]  

Stuart R. Hawtin

Charged Residues of the Conserved DRY Triplet of the Vasopressin V1a Receptor Provide Molecular Determinants for Cell Surface Delivery and Internalization
Mol Pharmacol 2005 68: 1172-1182. Published online July 27, 2005; 10.1124/mol.105.013359 [Abstract] [Full Text] [PDF]  

Tzu-Hurng Cheng, Neng-Lang Shih, Shin-Yee Chen, Jia-Wei Lin, Yen-Ling Chen, Cheng-Hsien Chen, Heng Lin, Ching-Feng Cheng, Wen-Ta Chiu, Danny Ling Wang, and Jin-Jer Chen

Nitric Oxide Inhibits Endothelin-1-Induced Cardiomyocyte Hypertrophy through cGMP-mediated Suppression of Extracellular-Signal Regulated Kinase Phosphorylation
Mol Pharmacol 2005 68: 1183-1192. Published online July 27, 2005; 10.1124/mol.105.014449 [Abstract] [Full Text] [PDF]  

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