Minireview:

Paul F. Pilch and Nils Bergenhem

Pharmacological Targeting of Adipocytes/Fat Metabolism for Treatment of Obesity and Diabetes
Mol Pharmacol 2006 70: 779-785. Published online June 7, 2006; 10.1124/mol.106.026104 [Abstract] [Full Text] [PDF]  

Accelerated Communications:

Joseph Tam, Orr Ofek, Ester Fride, Catherine Ledent, Yankel Gabet, Ralph Müller, Andreas Zimmer, Ken Mackie, Raphael Mechoulam, Esther Shohami, and Itai Bab

Involvement of Neuronal Cannabinoid Receptor CB1 in Regulation of Bone Mass and Bone Remodeling
Mol Pharmacol 2006 70: 786-792. Published online June 13, 2006; 10.1124/mol.106.026435 [Abstract] [Full Text] [PDF]  

Guilherme M. Santos, Valéry Afonso, Gustavo B. Barra, Marie Togashi, Paul Webb, Francisco A. R. Neves, Noureddine Lomri, and Abderrahim Lomri

Negative Regulation of Superoxide Dismutase-1 Promoter by Thyroid Hormone
Mol Pharmacol 2006 70: 793-800. Published online May 31, 2006; 10.1124/mol.106.025627 [Abstract] [Full Text] [PDF]  

Karla B. Mihalak, F. Ivy Carroll, and Charles W. Luetje

Varenicline Is a Partial Agonist at 42 and a Full Agonist at 7 Neuronal Nicotinic Receptors
Mol Pharmacol 2006 70: 801-805. Published online June 9, 2006; 10.1124/mol.106.025130 [Abstract] [Full Text] [PDF]  

Articles:

Emanuel Hänggi, Anne Freimoser Grundschober, Simone Leuthold, Peter J. Meier, and Marie V. St-Pierre

Functional Analysis of the Extracellular Cysteine Residues in the Human Organic Anion Transporting Polypeptide, OATP2B1
Mol Pharmacol 2006 70: 806-817. Published online June 5, 2006; 10.1124/mol.105.019547 [Abstract] [Full Text] [PDF]  

Tami Wolf-Goldberg, Izhak Michaelevski, Laura Sheu, Herbert Y. Gaisano, Dodo Chikvashvili, and Ilana Lotan

Target Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptors (t-SNAREs) Differently Regulate Activation and Inactivation Gating of Kv2.2 and Kv2.1: Implications on Pancreatic Islet Cell Kv Channels
Mol Pharmacol 2006 70: 818-828. Published online June 5, 2006; 10.1124/mol.105.021717 [Abstract] [Full Text] [PDF]  

Yukio Kato, Mikihiro Sugiura, Tomoko Sugiura, Tomohiko Wakayama, Yoshiyuki Kubo, Daisuke Kobayashi, Yoshimichi Sai, Ikumi Tamai, Shoichi Iseki, and Akira Tsuji

Organic Cation/Carnitine Transporter OCTN2 (Slc22a5) Is Responsible for Carnitine Transport across Apical Membranes of Small Intestinal Epithelial Cells in Mouse
Mol Pharmacol 2006 70: 829-837. Published online June 5, 2006; 10.1124/mol.106.024158 [Abstract] [Full Text] [PDF]  

Omeima Zeitoun, Noel M. Delos Santos, Lidia A. Gardner, Stephen W. White, and Suleiman W. Bahouth

Mutagenesis within Helix 6 of the Human ₁-Adrenergic Receptor Identifies Lysine³²⁴ as a Residue Involved in Imparting the High-Affinity Binding State of Agonists
Mol Pharmacol 2006 70: 838-850. Published online June 7, 2006; 10.1124/mol.106.025346 [Abstract] [Full Text] [PDF]  

Guo Jun Liu, Adrianna Kalous, Eryn L. Werry, and Max R. Bennett

Purine Release from Spinal Cord Microglia after Elevation of Calcium by Glutamate
Mol Pharmacol 2006 70: 851-859. Published online June 7, 2006; 10.1124/mol.105.021436 [Abstract] [Full Text] [PDF]  

Yong Zhang, Walter K. Vogel, Jennifer S. McCullar, Jeffrey A. Greenwood, and Theresa M. Filtz

Phospholipase C-3 and -1 Form Homodimers, but Not Heterodimers, through Catalytic and Carboxyl-Terminal Domains
Mol Pharmacol 2006 70: 860-868. Published online June 8, 2006; 10.1124/mol.105.021923 [Abstract] [Full Text] [PDF]  

Li Xu and Raymond C. Bergan

Genistein Inhibits Matrix Metalloproteinase Type 2 Activation and Prostate Cancer Cell Invasion by Blocking the Transforming Growth Factor -Mediated Activation of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2-27-kDa Heat Shock Protein Pathway
Mol Pharmacol 2006 70: 869-877. Published online June 13, 2006; 10.1124/mol.106.023861 [Abstract] [Full Text] [PDF]  

Tung-Chung Mou, Andreas Gille, Srividya Suryanarayana, Mark Richter, Roland Seifert, and Stephen R. Sprang

Broad Specificity of Mammalian Adenylyl Cyclase for Interaction with 2',3'-Substituted Purine- and Pyrimidine Nucleotide Inhibitors
Mol Pharmacol 2006 70: 878-886. Published online June 9, 2006; 10.1124/mol.106.026427 [Abstract] [Full Text] [PDF] [Data Supplement]   

Ryota Kikuchi, Hiroyuki Kusuhara, Naka Hattori, Kunio Shiota, Insook Kim, Frank J. Gonzalez, and Yuichi Sugiyama

Regulation of the Expression of Human Organic Anion Transporter 3 by Hepatocyte Nuclear Factor 1/ and DNA Methylation
Mol Pharmacol 2006 70: 887-896. Published online June 22, 2006; 10.1124/mol.106.025494 [Abstract] [Full Text] [PDF]  

Robert J. McKallip, Wentao Jia, Jerome Schlomer, James W. Warren, Prakash S. Nagarkatti, and Mitzi Nagarkatti

Cannabidiol-Induced Apoptosis in Human Leukemia Cells: A Novel Role of Cannabidiol in the Regulation of p22^phox and Nox4 Expression
Mol Pharmacol 2006 70: 897-908. Published online June 5, 2006; 10.1124/mol.106.023937 [Abstract] [Full Text] [PDF]  

Edoardo Parrella, Maurizio Giannì, Maddalena Fratelli, Maria Monica Barzago, Ivan Raska, Jr, Luisa Diomede, Mami Kurosaki, Claudio Pisano, Paolo Carminati, Lucio Merlini, Sabrina Dallavalle, Michele Tavecchio, Cecile Rochette-Egly, Mineko Terao, and Enrico Garattini

Antitumor Activity of the Retinoid-Related Molecules (E)-3-(4'-Hydroxy-3'-adamantylbiphenyl-4-yl)acrylic Acid (ST1926) and 6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalene Carboxylic Acid (CD437) in F9 Teratocarcinoma: Role of Retinoic Acid Receptor and Retinoid-Independent Pathways
Mol Pharmacol 2006 70: 909-924. Published online June 20, 2006; 10.1124/mol.106.023614 [Abstract] [Full Text] [PDF] [Data Supplement]   

Eiichi Hinoi, Takeshi Takarada, Yuriko Tsuchihashi, Sayumi Fujimori, Nobuaki Moriguchi, Liyang Wang, Kyosuke Uno, and Yukio Yoneda

A Molecular Mechanism of Pyruvate Protection against Cytotoxicity of Reactive Oxygen Species in Osteoblasts
Mol Pharmacol 2006 70: 925-935. Published online June 9, 2006; 10.1124/mol.106.024398 [Abstract] [Full Text] [PDF]  

Birgitte Holst, Manja Lang, Erik Brandt, Anders Bach, Andrew Howard, Thomas M. Frimurer, Annette Beck-Sickinger, and Thue W. Schwartz

Ghrelin Receptor Inverse Agonists: Identification of an Active Peptide Core and Its Interaction Epitopes on the Receptor
Mol Pharmacol 2006 70: 936-946. Published online June 23, 2006; 10.1124/mol.106.024422 [Abstract] [Full Text] [PDF]  

Michael J. Marks, Paul Whiteaker, and Allan C. Collins

Deletion of the 7, 2, or 4 Nicotinic Receptor Subunit Genes Identifies Highly Expressed Subtypes with Relatively Low Affinity for [³H]Epibatidine
Mol Pharmacol 2006 70: 947-959. Published online May 25, 2006; 10.1124/mol.106.025338 [Abstract] [Full Text] [PDF]  

Seoyoung Park, Jungsug Gwak, Munju Cho, Taeyun Song, Jaejoon Won, Dong-Eun Kim, Jae-Gook Shin, and Sangtaek Oh

Hexachlorophene Inhibits Wnt/-Catenin Pathway by Promoting Siah-Mediated -Catenin Degradation
Mol Pharmacol 2006 70: 960-966. Published online May 30, 2006; 10.1124/mol.106.024729 [Abstract] [Full Text] [PDF]  

Layla Azam and J. Michael McIntosh

Characterization of Nicotinic Acetylcholine Receptors That Modulate Nicotine-Evoked [³H]Norepinephrine Release from Mouse Hippocampal Synaptosomes
Mol Pharmacol 2006 70: 967-976. Published online May 30, 2006; 10.1124/mol.106.024513 [Abstract] [Full Text] [PDF]  

Bin-Nan Wu, Chien-Wen Chen, Shu-Fen Liou, Jwu-Lai Yeh, Hui-Hsuan Chung, and Ing-Jun Chen

Inhibition of Proinflammatory Tumor Necrosis Factor--Induced Inducible Nitric-Oxide Synthase by Xanthine-Based 7-[2-[4-(2-Chlorobenzene)piperazinyl]ethyl]-1,3-dimethylxanthine (KMUP-1) and 7-[2-[4-(4-Nitrobenzene)piperazinyl]ethyl]-1, 3-dimethylxanthine (KMUP-3) in Rat Trachea: The Involvement of Soluble Guanylate Cyclase and Protein Kinase G
Mol Pharmacol 2006 70: 977-985. Published online June 5, 2006; 10.1124/mol.106.024919 [Abstract] [Full Text] [PDF]  

Laura J. Sim-Selley, Nicole S. Schechter, W. Kirk Rorrer, George D. Dalton, Jerry Hernandez, Billy R. Martin, and Dana E. Selley

Prolonged Recovery Rate of CB₁ Receptor Adaptation after Cessation of Long-Term Cannabinoid Administration
Mol Pharmacol 2006 70: 986-996. Published online June 7, 2006; 10.1124/mol.105.019612 [Abstract] [Full Text] [PDF]  

Chiung-Huei Peng, Chien-Ning Huang, Shu-Ping Hsu, and Chau-Jong Wang

Penta-Acetyl Geniposide Induce Apoptosis in C6 Glioma Cells by Modulating the Activation of Neutral Sphingomyelinase-Induced p75 Nerve Growth Factor Receptor and Protein Kinase C Pathway
Mol Pharmacol 2006 70: 997-1004. Published online June 8, 2006; 10.1124/mol.106.022178 [Abstract] [Full Text] [PDF] [Data Supplement]   

Daniel M. Johnson, Elizabeth M. Garrett, Richard Rutter, Timothy P. Bonnert, Ying-Duo Gao, Richard E. Middleton, and Kathy G. Sutton

Functional Mapping of the Transient Receptor Potential Vanilloid 1 Intracellular Binding Site
Mol Pharmacol 2006 70: 1005-1012. Published online June 8, 2006; 10.1124/mol.106.023945 [Abstract] [Full Text] [PDF]  

Clotilde Mannoury la Cour, Salah El Mestikawy, Naïma Hanoun, Michel Hamon, and Laurence Lanfumey

Regional Differences in the Coupling of 5-Hydroxytryptamine-1A Receptors to G Proteins in the Rat Brain
Mol Pharmacol 2006 70: 1013-1021. Published online June 13, 2006; 10.1124/mol.106.022756 [Abstract] [Full Text] [PDF]  

Pamela A. Frizelle, Philip E. Chen, and David J. A. Wyllie

Equilibrium Constants for (R)-[(S)-1-(4-Bromo-phenyl)-ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-methyl]-phosphonic Acid (NVP-AAM077) Acting at Recombinant NR1/NR2A and NR1/NR2B N-Methyl-D-aspartate Receptors: Implications for Studies of Synaptic Transmission
Mol Pharmacol 2006 70: 1022-1032. Published online June 15, 2006; 10.1124/mol.106.024042 [Abstract] [Full Text] [PDF] [Data Supplement]   

Man-Soo Yoon, Jun Sik Lee, Byoung-Moon Choi, Young-Il Jeong, Chang-Min Lee, Jong-Hoon Park, Yuseok Moon, Si-Chan Sung, Sang Kwon Lee, Yun Hee Chang, Hae Young Chung, and Yeong-Min Park

Apigenin Inhibits Immunostimulatory Function of Dendritic Cells: Implication of Immunotherapeutic Adjuvant
Mol Pharmacol 2006 70: 1033-1044. Published online June 16, 2006; 10.1124/mol.106.024547 [Abstract] [Full Text] [PDF]  

Ke Liang, Yang Lu, Xinqun Li, Xiao Zeng, Robert I. Glazer, Gordon B. Mills, and Zhen Fan

Differential Roles of Phosphoinositide-Dependent Protein Kinase-1 and Akt1 Expression and Phosphorylation in Breast Cancer Cell Resistance to Paclitaxel, Doxorubicin, and Gemcitabine
Mol Pharmacol 2006 70: 1045-1052. Published online June 16, 2006; 10.1124/mol.106.023333 [Abstract] [Full Text] [PDF]  

In Sup Kil, Seoung Woo Shin, Hyun Seok Yeo, Young Sup Lee, and Jeen-Woo Park

Mitochondrial NADP⁺-Dependent Isocitrate Dehydrogenase Protects Cadmium-Induced Apoptosis
Mol Pharmacol 2006 70: 1053-1061. Published online June 19, 2006; 10.1124/mol.106.023515 [Abstract] [Full Text] [PDF]  

Garret R. Anderson, Aliya Hasan, Hao Yin, Ishtiaq Qadri, and Linda C. Quattrochi

Regulation of the CYP1A1 Gene by 2,3,7,8-Tetrachlorodibenzo-p-dioxin but Not by -Naphthoflavone or 3-Methylcholanthrene Is Altered in Hepatitis C Virus Replicon-Expressing Cells
Mol Pharmacol 2006 70: 1062-1070. Published online June 20, 2006; 10.1124/mol.106.024125 [Abstract] [Full Text] [PDF]  

Daniel Poeckel, Lars Tausch, Nicole Kather, Johann Jauch, and Oliver Werz

Boswellic Acids Stimulate Arachidonic Acid Release and 12-Lipoxygenase Activity in Human Platelets Independent of Ca²⁺ and Differentially Interact with Platelet-Type 12-Lipoxygenase
Mol Pharmacol 2006 70: 1071-1078. Published online June 20, 2006; 10.1124/mol.106.024836 [Abstract] [Full Text] [PDF]  

Khan Shoeb Zafar, David Siegel, and David Ross

A Potential Role for Cyclized Quinones Derived from Dopamine, DOPA, and 3,4-Dihydroxyphenylacetic Acid in Proteasomal Inhibition
Mol Pharmacol 2006 70: 1079-1086. Published online June 21, 2006; 10.1124/mol.106.024703 [Abstract] [Full Text] [PDF]  

Patrick T. Ronaldson and Reina Bendayan

HIV-1 Viral Envelope Glycoprotein gp120 Triggers an Inflammatory Response in Cultured Rat Astrocytes and Regulates the Functional Expression of P-Glycoprotein
Mol Pharmacol 2006 70: 1087-1098. Published online June 21, 2006; 10.1124/mol.106.025973 [Abstract] [Full Text] [PDF]  

Hee Sun Byun, Kyeong Ah Park, Minho Won, Keum-Jin Yang, Sanghee Shin, Longzhen Piao, Jin Young Kwak, Zee-Won Lee, Jongsun Park, Jeong Ho Seok, Zheng-Gang Liu, and Gang Min Hur

Phorbol 12-Myristate 13-Acetate Protects against Tumor Necrosis Factor (TNF)-Induced Necrotic Cell Death by Modulating the Recruitment of TNF Receptor 1-Associated Death Domain and Receptor-Interacting Protein into the TNF Receptor 1 Signaling Complex: Implication for the Regulatory Role of Protein Kinase C
Mol Pharmacol 2006 70: 1099-1108. Published online June 23, 2006; 10.1124/mol.106.025452 [Abstract] [Full Text] [PDF]  

Smitha Antony, Keli K. Agama, Ze-Hong Miao, Melinda Hollingshead, Susan L. Holbeck, Mollie H. Wright, Lyuba Varticovski, Muthukaman Nagarajan, Andrew Morrell, Mark Cushman, and Yves Pommier

Bisindenoisoquinoline Bis-1,3-{(5,6-dihydro-5,11-diketo-11H-indeno[1,2-c]isoquinoline)-6-propylamino}propane bis(trifluoroacetate) (NSC 727357), a DNA Intercalator and Topoisomerase Inhibitor with Antitumor Activity
Mol Pharmacol 2006 70: 1109-1120. Published online June 23, 2006; 10.1124/mol.106.024372 [Abstract] [Full Text] [PDF]  

Ofer Cohen, Chanoch Kronman, Lily Raveh, Ohad Mazor, Arie Ordentlich, and Avigdor Shafferman

Comparison of Polyethylene Glycol-Conjugated Recombinant Human Acetylcholinesterase and Serum Human Butyrylcholinesterase as Bioscavengers of Organophosphate Compounds
Mol Pharmacol 2006 70: 1121-1131. Published online June 26, 2006; 10.1124/mol.106.026179 [Abstract] [Full Text] [PDF]  

Stuart J. Mundell, Matthew L. Jones, Adam R. Hardy, Johanna F. Barton, Stephanie M. Beaucourt, Pamela B. Conley, and Alastair W. Poole

Distinct Roles for Protein Kinase C Isoforms in Regulating Platelet Purinergic Receptor Function
Mol Pharmacol 2006 70: 1132-1142. Published online June 27, 2006; 10.1124/mol.106.023549 [Abstract] [Full Text] [PDF]  

Kiyomi Nigorikawa, Kyoko Yoshikawa, Tomo Sasaki, Eiji Iida, Mariko Tsukamoto, Hitomi Murakami, Tomohiko Maehama, Kaoru Hazeki, and Osamu Hazeki

A Naphthoquinone Derivative, Shikonin, Has Insulin-Like Actions by Inhibiting Both Phosphatase and Tensin Homolog Deleted on Chromosome 10 and Tyrosine Phosphatases
Mol Pharmacol 2006 70: 1143-1149. Published online June 27, 2006; 10.1124/mol.106.025809 [Abstract] [Full Text] [PDF]  

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