Mol Pharm -- Table of Contents (70 [4])

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October 2006; 70 (4)   [Index by Author] [Cover Caption]

       Perspectives

       Accelerated Communication

       Articles

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Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF) |

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Perspectives:

Carmelle V. Remillard and Jason X.-J. Yuan: Transient Receptor Potential Channels and Caveolin-1: Good Friends in Tight Spaces
Mol Pharmacol 2006 70: 1151-1154. Published online July 27, 2006; 10.1124/mol.106.029280 [Abstract] [Full Text] [PDF] [Related Article]

Pamela L. Zeitlin: Is It Go or NO Go for S-Nitrosylation Modification-Based Therapies of Cystic Fibrosis Transmembrane Regulator Trafficking?
Mol Pharmacol 2006 70: 1155-1158. Published online July 28, 2006; 10.1124/mol.106.029207 [Abstract] [Full Text] [PDF] [Related Article]

Accelerated Communication:

William J. Wilkinson, Lin-Hua Jiang, Annmarie Surprenant, and R. Alan North: Role of Ectodomain Lysines in the Subunits of the Heteromeric P2X_2/3 Receptor
Mol Pharmacol 2006 70: 1159-1163. Published online July 13, 2006; 10.1124/mol.106.026658 [Abstract] [Full Text] [PDF]

Articles:

Giovanni Rizzo, Moises Disante, Andrea Mencarelli, Barbara Renga, Antimo Gioiello, Roberto Pellicciari, and Stefano Fiorucci: The Farnesoid X Receptor Promotes Adipocyte Differentiation and Regulates Adipose Cell Function in Vivo
Mol Pharmacol 2006 70: 1164-1173. Published online June 15, 2006; 10.1124/mol.106.023820 [Abstract] [Full Text] [PDF]

Angela M. Kwiatek, Richard D. Minshall, David R. Cool, Randal A. Skidgel, Asrar B. Malik, and Chinnaswamy Tiruppathi: Caveolin-1 Regulates Store-Operated Ca²⁺ Influx by Binding of Its Scaffolding Domain to Transient Receptor Potential Channel-1 in Endothelial Cells
Mol Pharmacol 2006 70: 1174-1183. Published online July 5, 2006; 10.1124/mol.105.021741 [Abstract] [Full Text] [PDF]

Kyung Sun Lee, So Ri Kim, Seoung Ju Park, Kyung Hoon Min, Ka Young Lee, Sun Mi Jin, Wan Hee Yoo, and Yong Chul Lee: Antioxidant Down-Regulates Interleukin-18 Expression in Asthma
Mol Pharmacol 2006 70: 1184-1193. Published online July 5, 2006; 10.1124/mol.106.024737 [Abstract] [Full Text] [PDF]

Wenchang Guo, Philip Reigan, David Siegel, Joseph Zirrolli, Daniel Gustafson, and David Ross: The Bioreduction of a Series of Benzoquinone Ansamycins by NAD(P)H:Quinone Oxidoreductase 1 to More Potent Heat Shock Protein 90 Inhibitors, the Hydroquinone Ansamycins
Mol Pharmacol 2006 70: 1194-1203. Published online July 6, 2006; 10.1124/mol.106.025643 [Abstract] [Full Text] [PDF] [Data supplement]

Niels Decher, Pradeep Kumar, Teresa Gonzalez, Bernard Pirard, and Michael C. Sanguinetti: Binding Site of a Novel Kv1.5 Blocker: A "Foot in the Door" against Atrial Fibrillation
Mol Pharmacol 2006 70: 1204-1211. Published online July 11, 2006; 10.1124/mol.106.026203 [Abstract] [Full Text] [PDF]

Björn Bauer, Xiaodong Yang, Anika M. S. Hartz, Emily R. Olson, Rong Zhao, J. Cory Kalvass, Gary M. Pollack, and David S. Miller: In Vivo Activation of Human Pregnane X Receptor Tightens the Blood-Brain Barrier to Methadone through P-Glycoprotein Up-Regulation
Mol Pharmacol 2006 70: 1212-1219. Published online July 12, 2006; 10.1124/mol.106.023796 [Abstract] [Full Text] [PDF]

Akiko Maeda, Tadao Maeda, Marcin Golczak, Yoshikazu Imanishi, Patrick Leahy, Ryo Kubota, and Krzysztof Palczewski: Effects of Potent Inhibitors of the Retinoid Cycle on Visual Function and Photoreceptor Protection from Light Damage in Mice
Mol Pharmacol 2006 70: 1220-1229. Published online July 12, 2006; 10.1124/mol.106.026823 [Abstract] [Full Text] [PDF] [Data Supplement]

Fan Gao, Georges Mer, Marco Tonelli, Scott B. Hansen, Thomas P. Burghardt, Palmer Taylor, and Steven M. Sine: Solution NMR of Acetylcholine Binding Protein Reveals Agonist-Mediated Conformational Change of the C-Loop
Mol Pharmacol 2006 70: 1230-1235. Published online July 17, 2006; 10.1124/mol.106.027185 [Abstract] [Full Text] [PDF]

Aldemar Degroot, Attila Köfalvi, Mark R. Wade, Richard J. Davis, Ricardo J. Rodrigues, Nelson Rebola, Rodrigo A. Cunha, and George G. Nomikos: CB₁ Receptor Antagonism Increases Hippocampal Acetylcholine Release: Site and Mechanism of Action
Mol Pharmacol 2006 70: 1236-1245. Published online July 19, 2006; 10.1124/mol.106.024661 [Abstract] [Full Text] [PDF]

Laurence Daulhac, Christophe Mallet, Christine Courteix, Monique Etienne, Eliane Duroux, Anne-Marie Privat, Alain Eschalier, and Joseph Fialip: Diabetes-Induced Mechanical Hyperalgesia Involves Spinal Mitogen-Activated Protein Kinase Activation in Neurons and Microglia via N-Methyl-D-aspartate-Dependent Mechanisms
Mol Pharmacol 2006 70: 1246-1254. Published online July 25, 2006; 10.1124/mol.106.025478 [Abstract] [Full Text] [PDF]

Masaru Shimomura, Maiko Yokota, Makoto Ihara, Miki Akamatsu, David B. Sattelle, and Kazuhiko Matsuda: Role in the Selectivity of Neonicotinoids of Insect-Specific Basic Residues in Loop D of the Nicotinic Acetylcholine Receptor Agonist Binding Site
Mol Pharmacol 2006 70: 1255-1263. Published online July 25, 2006; 10.1124/mol.106.026815 [Abstract] [Full Text] [PDF]

Carol Smith, Tariq Rahman, Nicole Toohey, Joseph Mazurkiewicz, Katharine Herrick-Davis, and Milt Teitler: Risperidone Irreversibly Binds to and Inactivates the h5-HT₇ Serotonin Receptor
Mol Pharmacol 2006 70: 1264-1270. Published online July 26, 2006; 10.1124/mol.106.024612 [Abstract] [Full Text] [PDF]

Panagiotis Karahalios, Dimitrios L. Kalpaxis, Hong Fu, Leonard Katz, Daniel N. Wilson, and George P. Dinos: On the Mechanism of Action of 9-O-Arylalkyloxime Derivatives of 6-O-Mycaminosyltylonolide, a New Class of 16-Membered Macrolide Antibiotics
Mol Pharmacol 2006 70: 1271-1280. Published online July 27, 2006; 10.1124/mol.106.026567 [Abstract] [Full Text] [PDF] [Data Supplement]

Mariko Shin, Insook Kim, Yusuke Inoue, Shioko Kimura, and Frank J. Gonzalez: Regulation of Mouse Hepatic ${alpha}$ -Amino- $beta$ -Carboxymuconate- ${epsilon}$ -Semialdehyde Decarboxylase, a Key Enzyme in the Tryptophan-Nicotinamide Adenine Dinucleotide Pathway, by Hepatocyte Nuclear Factor 4 ${alpha}$ and Peroxisome Proliferator-Activated Receptor ${alpha}$
Mol Pharmacol 2006 70: 1281-1290. Published online June 28, 2006; 10.1124/mol.106.026294 [Abstract] [Full Text] [PDF]

Xingguo Cheng, Jonathan Maher, Hong Lu, and Curtis D. Klaassen: Endocrine Regulation of Gender-Divergent Mouse Organic Anion-Transporting Polypeptide (Oatp) Expression
Mol Pharmacol 2006 70: 1291-1297. Published online June 28, 2006; 10.1124/mol.106.025122 [Abstract] [Full Text] [PDF] [Erratum]

Daniela Sarnataro, Simona Pisanti, Antonietta Santoro, Patrizia Gazzerro, Anna Maria Malfitano, Chiara Laezza, and Maurizio Bifulco: The Cannabinoid CB1 Receptor Antagonist Rimonabant (SR141716) Inhibits Human Breast Cancer Cell Proliferation through a Lipid Raft-Mediated Mechanism
Mol Pharmacol 2006 70: 1298-1306. Published online July 5, 2006; 10.1124/mol.106.025601 [Abstract] [Full Text] [PDF] [Data Supplement]

Mariana Bartos, Diego Rayes, and Cecilia Bouzat: Molecular Determinants of Pyrantel Selectivity in Nicotinic Receptors
Mol Pharmacol 2006 70: 1307-1318. Published online July 6, 2006; 10.1124/mol.106.026336 [Abstract] [Full Text] [PDF]

Rie Schultz Hansen, Thomas Goldin Diness, Torsten Christ, Erich Wettwer, Ursula Ravens, Søren-Peter Olesen, and Morten Grunnet: Biophysical Characterization of the New Human Ether-A-Go-Go-Related Gene Channel Opener NS3623 [N-(4-Bromo-2-(1H-tetrazol-5-yl)-phenyl)-N'-(3'-trifluoromethylphenyl)urea]
Mol Pharmacol 2006 70: 1319-1329. Published online July 6, 2006; 10.1124/mol.106.026492 [Abstract] [Full Text] [PDF]

Maroesja J. van Nimwegen, Merei Huigsloot, Annamarie Camier, Ine B. Tijdens, and Bob van de Water: Focal Adhesion Kinase and Protein Kinase B Cooperate to Suppress Doxorubicin-Induced Apoptosis of Breast Tumor Cells
Mol Pharmacol 2006 70: 1330-1339. Published online July 6, 2006; 10.1124/mol.106.026195 [Abstract] [Full Text] [PDF]

Elaine M. Quinet, Dawn A. Savio, Anita R. Halpern, Liang Chen, Gertrude U. Schuster, Jan-Åke Gustafsson, Mike D. Basso, and Ponnal Nambi: Liver X Receptor (LXR)- $beta$ Regulation in LXR ${alpha}$ -Deficient Mice: Implications for Therapeutic Targeting
Mol Pharmacol 2006 70: 1340-1349. Published online July 6, 2006; 10.1124/mol.106.022608 [Abstract] [Full Text] [PDF]

Steven Broadbent, Paul J. Groot-Kormelink, Paraskevi A. Krashia, Patricia C. Harkness, Neil S. Millar, Marco Beato, and Lucia G. Sivilotti: Incorporation of the $beta$ 3 Subunit Has a Dominant-Negative Effect on the Function of Recombinant Central-Type Neuronal Nicotinic Receptors
Mol Pharmacol 2006 70: 1350-1357. Published online July 5, 2006; 10.1124/mol.106.026682 [Abstract] [Full Text] [PDF]

Prem Tumkosit, Alexander Kuryatov, Jie Luo, and Jon Lindstrom: $beta$ 3 Subunits Promote Expression and Nicotine-Induced Up-Regulation of Human Nicotinic ${alpha}$ 6^* Nicotinic Acetylcholine Receptors Expressed in Transfected Cell Lines
Mol Pharmacol 2006 70: 1358-1368. Published online July 11, 2006; 10.1124/mol.106.027326 [Abstract] [Full Text] [PDF]

Richard S. Pollenz, Sarah E. Wilson, and Edward J. Dougherty: Role of Endogenous XAP2 Protein on the Localization and Nucleocytoplasmic Shuttling of the Endogenous Mouse Ah^b-1 Receptor in the Presence and Absence of Ligand
Mol Pharmacol 2006 70: 1369-1379. Published online July 11, 2006; 10.1124/mol.106.027672 [Abstract] [Full Text] [PDF]

Wei-Ya Wang, Yang-Chang Wu, and Chin-Chung Wu: Prevention of Platelet Glycoprotein IIb/IIIa Activation by 3,4-Methylenedioxy- $beta$ -Nitrostyrene, A Novel Tyrosine Kinase Inhibitor
Mol Pharmacol 2006 70: 1380-1389. Published online July 12, 2006; 10.1124/mol.106.023986 [Abstract] [Full Text] [PDF]

Alison K. Holzer, Gerald H. Manorek, and Stephen B. Howell: Contribution of the Major Copper Influx Transporter CTR1 to the Cellular Accumulation of Cisplatin, Carboplatin, and Oxaliplatin
Mol Pharmacol 2006 70: 1390-1394. Published online July 17, 2006; 10.1124/mol.106.022624 [Abstract] [Full Text] [PDF]

Yael Friedmann, Anat Shriki, Estelle R. Bennett, Stella Golos, Ron Diskin, Irit Marbach, Eyal Bengal, and David Engelberg: JX401, A p38 ${alpha}$ Inhibitor Containing a 4-Benzylpiperidine Motif, Identified via a Novel Screening System in Yeast
Mol Pharmacol 2006 70: 1395-1405. Published online July 17, 2006; 10.1124/mol.106.022962 [Abstract] [Full Text] [PDF]

Richa S. Mukherjee, Edward W. McBride, Martin Beinborn, Kathleen Dunlap, and Alan S. Kopin: Point Mutations in Either Subunit of the GABA_B Receptor Confer Constitutive Activity to the Heterodimer
Mol Pharmacol 2006 70: 1406-1413. Published online July 17, 2006; 10.1124/mol.106.024463 [Abstract] [Full Text] [PDF] [Data Supplement]

Adele Vivacqua, Daniela Bonofiglio, Lidia Albanito, Antonio Madeo, Vittoria Rago, Amalia Carpino, Anna Maria Musti, Didier Picard, Sebastiano Andò, and Marcello Maggiolini: 17 $beta$ -Estradiol, Genistein, and 4-Hydroxytamoxifen Induce the Proliferation of Thyroid Cancer Cells through the G Protein-Coupled Receptor GPR30
Mol Pharmacol 2006 70: 1414-1423. Published online July 11, 2006; 10.1124/mol.106.026344 [Abstract] [Full Text] [PDF]

Yicheng Zhang, Jonathan Soboloff, Ziping Zhu, and Stuart A. Berger: Inhibition of Ca²⁺ Influx Is Required for Mitochondrial Reactive Oxygen Species-Induced Endoplasmic Reticulum Ca²⁺ Depletion and Cell Death in Leukemia Cells
Mol Pharmacol 2006 70: 1424-1434. Published online July 18, 2006; 10.1124/mol.106.024323 [Abstract] [Full Text] [PDF]

Khalequz Zaman, Silvia Carraro, Joseph Doherty, Edward M. Henderson, Elizabeth Lendermon, Lei Liu, George Verghese, Molly Zigler, Mark Ross, Edward Park, Lisa A. Palmer, Allan Doctor, Jonathan S. Stamler, and Benjamin Gaston: S-Nitrosylating Agents: A Novel Class of Compounds That Increase Cystic Fibrosis Transmembrane Conductance Regulator Expression and Maturation in Epithelial Cells
Mol Pharmacol 2006 70: 1435-1442. Published online July 20, 2006; 10.1124/mol.106.023242 [Abstract] [Full Text] [PDF]

Chun-Wei Yeh, Sheng-Shun Huang, Ru-Ping Lee, and Benjamin Yat-Ming Yung: Ras-Dependent Recruitment of c-Myc for Transcriptional Activation of Nucleophosmin/B23 in Highly Malignant U1 Bladder Cancer Cells
Mol Pharmacol 2006 70: 1443-1453. Published online July 20, 2006; 10.1124/mol.106.024810 [Abstract] [Full Text] [PDF]

Yingxian Xiao, Hong Fan, John L. Musachio, Zhi-Liang Wei, Sheela K. Chellappan, Alan P. Kozikowski, and Kenneth J. Kellar: Sazetidine-A, A Novel Ligand That Desensitizes ${alpha}$ 4 $beta$ 2 Nicotinic Acetylcholine Receptors without Activating Them
Mol Pharmacol 2006 70: 1454-1460. Published online July 20, 2006; 10.1124/mol.106.027318 [Abstract] [Full Text] [PDF]

Laura N. Stemmle, Timothy A. Fields, and Patrick J. Casey: The Regulator of G Protein Signaling Domain of Axin Selectively Interacts with G ${alpha}$ ₁₂ but Not G ${alpha}$ ₁₃
Mol Pharmacol 2006 70: 1461-1468. Published online July 25, 2006; 10.1124/mol.106.023705 [Abstract] [Full Text] [PDF]

Cover Caption:

About the cover: Homology models of the agonist binding domain of the wild-type α4β2 (A) and Dα2β2 (B) nAChRs and their T77R;E79V mutants (C, α4β2 nAChR; D, Dα2β2 nAChRs) bound by imidacloprid constructed using the crystal structure (PDB code 1UW6) of the acetylcholine binding protein (AChBP) from snail Lymnaea stagnalis. See the article by Shimonura et al. on page 1255 of this issue.