EDITOR'S NOTE:

P. Jeffrey Conn

Molecular Pharmacology in the Postgenomic Era
Mol Pharmacol 2007 71: 1-2. [Full Text] [PDF]  

Accelerated Communication:

Jan Balzarini, Yven Van Herrewege, Kurt Vermeire, Guido Vanham, and Dominique Schols

Carbohydrate-Binding Agents Efficiently Prevent Dendritic Cell-Specific Intercellular Adhesion Molecule-3-Grabbing Nonintegrin (DC-SIGN)-Directed HIV-1 Transmission to T Lymphocytes
Mol Pharmacol 2007 71: 3-11. Published online October 20, 2006; 10.1124/mol.106.030155 [Abstract] [Full Text] [PDF]  

Articles:

Jeannette Endres-Becker, Paul A. Heppenstall, Shaaban A. Mousa, Dominika Labuz, Alexander Oksche, Michael Schäfer, Christoph Stein, and Christian Zöllner

µ-Opioid Receptor Activation Modulates Transient Receptor Potential Vanilloid 1 (TRPV1) Currents in Sensory Neurons in A Model of Inflammatory Pain
Mol Pharmacol 2007 71: 12-18. Published online September 27, 2006; 10.1124/mol.106.026740 [Abstract] [Full Text] [PDF]  

Brian E. Hawes, Kim A. O'Neill, Xiaorui Yao, James H. Crona, Harry R. Davis, Jr., Michael P. Graziano, and Scott W. Altmann

In Vivo Responsiveness to Ezetimibe Correlates with Niemann-Pick C1 Like-1 (NPC1L1) Binding Affinity: Comparison of Multiple Species NPC1L1 Orthologs
Mol Pharmacol 2007 71: 19-29. Published online September 27, 2006; 10.1124/mol.106.027896 [Abstract] [Full Text] [PDF] [Data Supplement]   

Toni Ahtoniemi, Gundars Goldsteins, Velta Keksa-Goldsteine, Tarja Malm, Katja Kanninen, Antero Salminen, and Jari Koistinaho

Pyrrolidine Dithiocarbamate Inhibits Induction of Immunoproteasome and Decreases Survival in a Rat Model of Amyotrophic Lateral Sclerosis
Mol Pharmacol 2007 71: 30-37. Published online September 28, 2006; 10.1124/mol.106.028415 [Abstract] [Full Text] [PDF]  

Feyza Sancar, Spencer S. Ericksen, Amy M. Kucken, Jeremy A. Teissére, and Cynthia Czajkowski

Structural Determinants for High-Affinity Zolpidem Binding to GABA-A receptors
Mol Pharmacol 2007 71: 38-46. Published online September 29, 2006; 10.1124/mol.106.029595 [Abstract] [Full Text] [PDF]  

Tuan M. Tran, Jacqueline Friedman, Faiza Baameur, Brian J. Knoll, Robert H. Moore, and Richard B. Clark

Characterization of ₂-Adrenergic Receptor Dephosphorylation: Comparison with the Rate of Resensitization
Mol Pharmacol 2007 71: 47-60. Published online September 29, 2006; 10.1124/mol.106.028456 [Abstract] [Full Text] [PDF]  

Ravindra Kamath, Zhihua Jiang, Guoming Sun, Jack C. Yalowich, and R. Baskaran

c-Abl Kinase Regulates Curcumin-Induced Cell Death through Activation of c-Jun N-Terminal Kinase
Mol Pharmacol 2007 71: 61-72. Published online October 4, 2006; 10.1124/mol.106.026575 [Abstract] [Full Text] [PDF]  

Walt F. Lima, John B. Rose, Josh G. Nichols, Hongjiang Wu, Michael T. Migawa, Tadeusz K. Wyrzykiewicz, Guillermo Vasquez, Eric E. Swayze, and Stanley T. Crooke

The Positional Influence of the Helical Geometry of the Heteroduplex Substrate on Human RNase H1 Catalysis
Mol Pharmacol 2007 71: 73-82. Published online October 6, 2006; 10.1124/mol.106.025429 [Abstract] [Full Text] [PDF]  

Walt F. Lima, John B. Rose, Josh G. Nichols, Hongjiang Wu, Michael T. Migawa, Tadeusz K. Wyrzykiewicz, Andrew M. Siwkowski, and Stanley T. Crooke

Human RNase H1 Discriminates between Subtle Variations in the Structure of the Heteroduplex Substrate
Mol Pharmacol 2007 71: 83-91. Published online October 6, 2006; 10.1124/mol.106.025015 [Abstract] [Full Text] [PDF]  

Mark T. Young, Pablo Pelegrin, and Annmarie Surprenant

Amino Acid Residues in the P2X₇ Receptor that Mediate Differential Sensitivity to ATP and BzATP
Mol Pharmacol 2007 71: 92-100. Published online October 10, 2006; 10.1124/mol.106.030163 [Abstract] [Full Text] [PDF]  

Xiang-Hong Peng, Prasanthi Karna, Ruth M. O'Regan, XiuJu Liu, Rajesh Naithani, Robert M. Moriarty, William C. Wood, Ho-Young Lee, and Lily Yang

Down-Regulation of Inhibitor of Apoptosis Proteins by Deguelin Selectively Induces Apoptosis in Breast Cancer Cells
Mol Pharmacol 2007 71: 101-111. Published online October 11, 2006; 10.1124/mol.106.027367 [Abstract] [Full Text] [PDF]  

Marc Awobuluyi, Jin Yang, Yuzhen Ye, Jon E. Chatterton, Adam Godzik, Stuart A. Lipton, and Dongxian Zhang

Subunit-Specific Roles of Glycine-Binding Domains in Activation of NR1/NR3 N-Methyl-D-aspartate Receptors
Mol Pharmacol 2007 71: 112-122. Published online October 17, 2006; 10.1124/mol.106.030700 [Abstract] [Full Text] [PDF]  

Ying-Jian Liang, Dai-Fei Wu, Li-Quan Yang, Volker Höllt, and Thomas Koch

Interaction of the µ-Opioid Receptor with Synaptophysin Influences Receptor Trafficking and Signaling
Mol Pharmacol 2007 71: 123-131. Published online September 27, 2006; 10.1124/mol.106.026062 [Abstract] [Full Text] [PDF]  

Salvatore Cuzzocrea, Stefano Bruscoli, Concetta Crisafulli, Emanuela Mazzon, Massimiliano Agostini, Carmelo Muià, Emanuela Esposito, Rosa Di Virgilio, Rosaria Meli, Elisabetta Vegeto, Adriana Maggi, and Carlo Riccardi

Estrogen Receptor Antagonist Fulvestrant (ICI 182,780) Inhibits the Anti-Inflammatory Effect of Glucocorticoids
Mol Pharmacol 2007 71: 132-144. Published online October 11, 2006; 10.1124/mol.106.029629 [Abstract] [Full Text] [PDF]  

Narendra P. Singh, Mitzi Nagarkatti, and Prakash S. Nagarkatti

Role of Dioxin Response Element and Nuclear Factor-B Motifs in 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Mediated Regulation of Fas and Fas Ligand Expression
Mol Pharmacol 2007 71: 145-157. Published online August 29, 2006; 10.1124/mol.106.028365 [Abstract] [Full Text] [PDF]  

C. Y. Ung, H. Li, C. W. Yap, and Y. Z. Chen

In Silico Prediction of Pregnane X Receptor Activators by Machine Learning Approache
Mol Pharmacol 2007 71: 158-168. Published online September 26, 2006; 10.1124/mol.106.027623 [Abstract] [Full Text] [PDF] [Data Supplement]   

David L. Roman, Jeffery N. Talbot, Rebecca A. Roof, Roger K. Sunahara, John R. Traynor, and Richard R. Neubig

Identification of Small-Molecule Inhibitors of RGS4 Using a High-Throughput Flow Cytometry Protein Interaction Assay
Mol Pharmacol 2007 71: 169-175. Published online September 29, 2006; 10.1124/mol.106.028670 [Abstract] [Full Text] [PDF]  

Scott R. Bright, Elizabeth D. Rich, and Michael D. Varnum

Regulation of Human Cone Cyclic Nucleotide-Gated Channels by Endogenous Phospholipids and Exogenously Applied Phosphatidylinositol 3,4,5-trisphosphate
Mol Pharmacol 2007 71: 176-183. Published online October 3, 2006; 10.1124/mol.106.026401 [Abstract] [Full Text] [PDF]  

Marni Brisson, Caleb Foster, Peter Wipf, Beomjun Joo, Robert J. Tomko, Jr., Theresa Nguyen, and John S. Lazo

Independent Mechanistic Inhibition of Cdc25 Phosphatases by a Natural Product Caulibugulone
Mol Pharmacol 2007 71: 184-192. Published online October 3, 2006; 10.1124/mol.106.028589 [Abstract] [Full Text] [PDF]  

John P. Evans, Fengyun Xu, Mint Sirisawad, Richard Miller, Louie Naumovski, and Paul R. Ortiz de Montellano

Motexafin Gadolinium-Induced Cell Death Correlates with Heme oxygenase-1 Expression and Inhibition of P450 Reductase-Dependent Activities
Mol Pharmacol 2007 71: 193-200. Published online October 3, 2006; 10.1124/mol.106.028407 [Abstract] [Full Text] [PDF]  

Lorraine Ng, Kathleen Nichols, Kelly O'Rourke, Ann Maslen, and Gordon M. Kirby

Repression of Human GSTA1 by Interleukin-1 Is Mediated by Variant Hepatic Nuclear Factor-1C
Mol Pharmacol 2007 71: 201-208. Published online October 4, 2006; 10.1124/mol.106.028563 [Abstract] [Full Text] [PDF]  

Kwang Seok Ahn, Gautam Sethi, and Bharat B. Aggarwal

Embelin, an Inhibitor of X Chromosome-Linked Inhibitor-of-Apoptosis Protein, Blocks Nuclear Factor-B (NF-B) Signaling Pathway Leading to Suppression of NF-B-Regulated Antiapoptotic and Metastatic Gene Products
Mol Pharmacol 2007 71: 209-219. Published online October 6, 2006; 10.1124/mol.106.028787 [Abstract] [Full Text] [PDF]  

Changcheng Zhou, Emma-Jane Poulton, Felix Grün, Theo K. Bammler, Bruce Blumberg, Kenneth E. Thummel, and David L. Eaton

The Dietary Isothiocyanate Sulforaphane Is an Antagonist of the Human Steroid and Xenobiotic Nuclear Receptor
Mol Pharmacol 2007 71: 220-229. Published online October 6, 2006; 10.1124/mol.106.029264 [Abstract] [Full Text] [PDF]  

Concetta Dipace, Uhna Sung, Francesca Binda, Randy D. Blakely, and Aurelio Galli

Amphetamine Induces a Calcium/Calmodulin-Dependent Protein Kinase II-Dependent Reduction in Norepinephrine Transporter Surface Expression Linked to Changes in Syntaxin 1A/Transporter Complexes
Mol Pharmacol 2007 71: 230-239. Published online October 10, 2006; 10.1124/mol.106.026690 [Abstract] [Full Text] [PDF]  

Pauline Breedveld, Dick Pluim, Greta Cipriani, Femke Dahlhaus, Maria A. J. van Eijndhoven, Cornelia J. F. de Wolf, Annemieke Kuil, Jos H. Beijnen, George L. Scheffer, Gerrit Jansen, Piet Borst, and Jan H. M. Schellens

The Effect of Low pH on Breast Cancer Resistance Protein (ABCG2)-Mediated Transport of Methotrexate, 7-Hydroxymethotrexate, Methotrexate Diglutamate, Folic Acid, Mitoxantrone, Topotecan, and Resveratrol in In Vitro Drug Transport Models
Mol Pharmacol 2007 71: 240-249. Published online October 10, 2006; 10.1124/mol.106.028167 [Abstract] [Full Text] [PDF]  

Makoto Osanai, Nami Nishikiori, Masaki Murata, Hideki Chiba, Takashi Kojima, and Norimasa Sawada

Cellular Retinoic Acid Bioavailability Determines Epithelial Integrity: Role of Retinoic Acid Receptor Agonists in Colitis
Mol Pharmacol 2007 71: 250-258. Published online October 11, 2006; 10.1124/mol.106.029579 [Abstract] [Full Text] [PDF]  

Adly Yacoub, William Hawkins, David Hanna, Hong Young, Margaret A. Park, Mark Grant, John D. Roberts, David T. Curiel, Paul B. Fisher, Kristoffer Valerie, Steven Grant, Michael P. Hagan, and Paul Dent

Human Chorionic Gonadotropin Modulates Prostate Cancer Cell Survival after Irradiation or HMG CoA Reductase Inhibitor Treatment
Mol Pharmacol 2007 71: 259-275. Published online October 18, 2006; 10.1124/mol.106.031153 [Abstract] [Full Text] [PDF]  

C. Wolf, M. Brüss, B. Hänisch, M. Göthert, I. von Kügelgen, and G. J. Molderings

Molecular Basis for the Antiproliferative Effect of Agmatine in Tumor Cells of Colonic, Hepatic, and Neuronal Origin
Mol Pharmacol 2007 71: 276-283. Published online October 17, 2006; 10.1124/mol.106.028449 [Abstract] [Full Text] [PDF]  

Ulises Meza, Ashish Thapliyal, Roger A. Bannister, and Brett A. Adams

Neurokinin 1 Receptors Trigger Overlapping Stimulation and Inhibition of Ca_V2.3 (R-Type) Calcium Channels
Mol Pharmacol 2007 71: 284-293. Published online October 18, 2006; 10.1124/mol.106.028530 [Abstract] [Full Text] [PDF]  

Keiko Shimamoto, Yasuto Otsubo, Yasushi Shigeri, Yoshimi Yasuda-Kamatani, Masamichi Satoh, Shuji Kaneko, and Takayuki Nakagawa

Characterization of the Tritium-Labeled Analog of L-threo--Benzyloxyaspartate Binding to Glutamate Transporters
Mol Pharmacol 2007 71: 294-302. Published online October 17, 2006; 10.1124/mol.106.027250 [Abstract] [Full Text] [PDF]  

Ju Shi, Bozena Zemaitaitis, and Nancy A. Muma

Phosphorylation of G₁₁ Protein Contributes to Agonist-Induced Desensitization of 5-HT_2A Receptor Signaling
Mol Pharmacol 2007 71: 303-313. Published online October 20, 2006; 10.1124/mol.106.028241 [Abstract] [Full Text] [PDF]  

Shujie Han, Stewart M. Knoepp, Mark A. Hallman, and Kathryn E. Meier

RasGRP1 Confers the Phorbol Ester-Sensitive Phenotype to EL4 Lymphoma Cells
Mol Pharmacol 2007 71: 314-322. Published online October 25, 2006; 10.1124/mol.106.028639 [Abstract] [Full Text] [PDF]  

Martin Fugere, Jon Appel, Richard A. Houghten, Iris Lindberg, and Robert Day

Short Polybasic Peptide Sequences Are Potent Inhibitors of PC5/6 and PC7: Use of Positional Scanning-Synthetic Peptide Combinatorial Libraries as a Tool for the Optimization of Inhibitory Sequences
Mol Pharmacol 2007 71: 323-332. Published online September 29, 2006; 10.1124/mol.106.027946 [Abstract] [Full Text] [PDF]  

B. Ory, F. Blanchard, S. Battaglia, F. Gouin, F. Rédini, and D. Heymann

Zoledronic Acid Activates the DNA S-Phase Checkpoint and Induces Osteosarcoma Cell Death Characterized by Apoptosis-Inducing Factor and Endonuclease-G Translocation Independently of p53 and Retinoblastoma Status
Mol Pharmacol 2007 71: 333-343. Published online October 18, 2006; 10.1124/mol.106.028837 [Abstract] [Full Text] [PDF]  

Hsien-Yeh Hsu, Hua-Lin Wu, Sai-Koong Tan, Vivian Pei-Hsin Li, Wei-Ting Wang, Jason Hsu, and Ching-Hsun Cheng

Geldanamycin Interferes with the 90-kDa Heat Shock Protein, Affecting Lipopolysaccharide-Mediated Interleukin-1 Expression and Apoptosis within Macrophages
Mol Pharmacol 2007 71: 344-356. Published online July 25, 2006; 10.1124/mol.106.024240 [Abstract] [Full Text] [PDF]  

Stefanie Zorbas-Seifried, Michael A. Jakupec, Nikolay V. Kukushkin, Michael Groessl, Christian G. Hartinger, Olga Semenova, Haralabos Zorbas, Vadim Yu. Kukushkin, and Bernhard K. Keppler

Reversion of Structure-Activity Relationships of Antitumor Platinum Complexes by Acetoxime but Not Hydroxylamine Ligands
Mol Pharmacol 2007 71: 357-365. Published online October 18, 2006; 10.1124/mol.106.030726 [Abstract] [Full Text] [PDF]  

Marisa Sousa, Jiraporn Ousingsawat, Roswitha Seitz, Supaporn Puntheeranurak, Ana Regalado, André Schmidt, Tiago Grego, Chaweewan Jansakul, Margarida D. Amaral, Rainer Schreiber, and Karl Kunzelmann

An Extract from the Medicinal Plant Phyllanthus acidus and Its Isolated Compounds Induce Airway Chloride Secretion: A Potential Treatment for Cystic Fibrosis
Mol Pharmacol 2007 71: 366-376. Published online October 25, 2006; 10.1124/mol.106.025262 [Abstract] [Full Text] [PDF]  

Yuanyuan Zhang, Wei Li, and Mary Vore

Translational Regulation of Rat Multidrug Resistance-Associated Protein 2 Expression Is Mediated by Upstream Open Reading Frames in the 5' Untranslated Region
Mol Pharmacol 2007 71: 377-383. Published online October 25, 2006; 10.1124/mol.106.029793 [Abstract] [Full Text] [PDF]  

Letters to the Editor:

Richard S. Pollenz

Comments on "Calpain Mediates the Dioxin-Induced Activation and Down-Regulation of the Aryl Hydrocarbon Receptor"
Mol Pharmacol 2007 71: 384-385. [Full Text] [PDF]  

Sakina E. Eltom and Yolanda Dale

Response to Comments on "Calpain Mediates the Dioxin-Induced Activation and Down-Regulation of the Aryl Hydrocarbon Receptor"
Mol Pharmacol 2007 71: 386-387. [Full Text] [PDF]  

Notice of Retraction:

Re: Henschler R, Brennscheidt U, Mertelsmann R, and Herrmann F (1991) Induction of c-jun expression in the myeloid leukemia cell line KG-1 by 1--D-arabinofuranosylcytosine. Mol Pharmacol 39:171-176
Mol Pharmacol 2007 71: 388. [Full Text] [PDF]  

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