Mol Pharm -- Table of Contents (71 [4])

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April 2007; 71 (4)   [Index by Author] [Cover Caption]

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Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF) |

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Minireview:

G. Enrico Rovati, Valérie Capra, and Richard R. Neubig: The Highly Conserved DRY Motif of Class A G Protein-Coupled Receptors: Beyond the Ground State
Mol Pharmacol 2007 71: 959-964. Published online December 27, 2006; 10.1124/mol.106.029470 [Abstract] [Full Text] [PDF]

Perspective:

Laura M. Bohn: Constitutive Trafficking—More Than Just Running in Circles?
Mol Pharmacol 2007 71: 957-958. Published online January 24, 2007; 10.1124/mol.107.034223 [Abstract] [Full Text] [PDF] [Related Article]

Articles:

Jin Hee Shin, Sung Ig Cho, Hyang Ran Lim, Jae Keun Lee, Young Ae Lee, Jai Sung Noh, In Soo Joo, Kee-Won Kim, and Byoung Joo Gwag: Concurrent Administration of Neu2000 and Lithium Produces Marked Improvement of Motor Neuron Survival, Motor Function, and Mortality in a Mouse Model of Amyotrophic Lateral Sclerosis
Mol Pharmacol 2007 71: 965-975. Published online November 14, 2006; 10.1124/mol.106.030676 [Abstract] [Full Text] [PDF] [Data Supplement]

Neil A. McDonald, Christopher M. Henstridge, Christopher N. Connolly, and Andrew J. Irving: An Essential Role for Constitutive Endocytosis, but Not Activity, in the Axonal Targeting of the CB₁ Cannabinoid Receptor
Mol Pharmacol 2007 71: 976-984. Published online December 20, 2006; 10.1124/mol.106.029348 [Abstract] [Full Text] [PDF]

Ken-ichiro Tanaka, Shinji Tsutsumi, Yasuhiro Arai, Tatsuya Hoshino, Keitarou Suzuki, Eiichi Takaki, Takaaki Ito, Koji Takeuchi, Akira Nakai, and Tohru Mizushima: Genetic Evidence for a Protective Role of Heat Shock Factor 1 against Irritant-Induced Gastric Lesions
Mol Pharmacol 2007 71: 985-993. Published online December 22, 2006; 10.1124/mol.106.033282 [Abstract] [Full Text] [PDF]

Leigh A. Stoddart, Andrew J. Brown, and Graeme Milligan: Uncovering the Pharmacology of the G Protein-Coupled Receptor GPR40: High Apparent Constitutive Activity in Guanosine 5'-O-(3-[³⁵S]thio)triphosphate Binding Studies Reflects Binding of an Endogenous Agonist
Mol Pharmacol 2007 71: 994-1005. Published online January 2, 2007; 10.1124/mol.106.031534 [Abstract] [Full Text] [PDF]

Chrysoula Leontiou, Gary P. Watters, Kathryn L. Gilroy, Pauline Heslop, Ian G. Cowell, Kate Craig, Robert N. Lightowlers, Jeremy H. Lakey, and Caroline A. Austin: Differential Selection of Acridine Resistance Mutations in Human DNA Topoisomerase II $beta$ Is Dependent on the Acridine Structure
Mol Pharmacol 2007 71: 1006-1014. Published online January 5, 2007; 10.1124/mol.106.032953 [Abstract] [Full Text] [PDF] [Data Supplement]

Juan F. Lopez-Gimenez, Meritxell Canals, John D. Pediani, and Graeme Milligan: The ${alpha}$ _1b-Adrenoceptor Exists as a Higher-Order Oligomer: Effective Oligomerization Is Required for Receptor Maturation, Surface Delivery, and Function
Mol Pharmacol 2007 71: 1015-1029. Published online January 12, 2007; 10.1124/mol.106.033035 [Abstract] [Full Text] [PDF] [Data Supplement]

Zhenglin Gu, Qian Jiang, and Zhen Yan: RGS4 Modulates Serotonin Signaling in Prefrontal Cortex and Links to Serotonin Dysfunction in a Rat Model of Schizophrenia
Mol Pharmacol 2007 71: 1030-1039. Published online January 12, 2007; 10.1124/mol.106.032490 [Abstract] [Full Text] [PDF]

Johannes Bodenstein, Roger K. Sunahara, and Richard R. Neubig: N-Terminal Residues Control Proteasomal Degradation of RGS2, RGS4, and RGS5 in Human Embryonic Kidney 293 Cells
Mol Pharmacol 2007 71: 1040-1050. Published online January 12, 2007; 10.1124/mol.106.029397 [Abstract] [Full Text] [PDF]

Timothy Wiltshire, Jamie Senft, Yutian Wang, Gregory W. Konat, Sharon L. Wenger, Eddie Reed, and Weixin Wang: BRCA1 Contributes to Cell Cycle Arrest and Chemoresistance in Response to the Anticancer Agent Irofulven
Mol Pharmacol 2007 71: 1051-1060. Published online January 17, 2007; 10.1124/mol.106.029504 [Abstract] [Full Text] [PDF]

Igor A. Schepetkin, Liliya N. Kirpotina, Andrei I. Khlebnikov, and Mark T. Quinn: High-Throughput Screening for Small-Molecule Activators of Neutrophils: Identification of Novel N-Formyl Peptide Receptor Agonists
Mol Pharmacol 2007 71: 1061-1074. Published online January 17, 2007; 10.1124/mol.106.033100 [Abstract] [Full Text] [PDF] [Data Supplement]

Takashi Morimoto, Kazuho Sakamoto, Hiroko Sade, Susumu Ohya, Katsuhiko Muraki, and Yuji Imaizumi: Voltage-Sensitive Oxonol Dyes Are Novel Large-Conductance Ca²⁺-Activated K⁺ Channel Activators Selective for $beta$ 1 and $beta$ 4 but Not for $beta$ 2 Subunits
Mol Pharmacol 2007 71: 1075-1088. Published online January 5, 2007; 10.1124/mol.106.031146 [Abstract] [Full Text] [PDF]

Corinne Planchamp, Antoine Hadengue, Bruno Stieger, Joëlle Bourquin, Alain Vonlaufen, Jean-Louis Frossard, Rafael Quadri, Christoph D. Becker, and Catherine M. Pastor: Function of Both Sinusoidal and Canalicular Transporters Controls the Concentration of Organic Anions within Hepatocytes
Mol Pharmacol 2007 71: 1089-1097. Published online January 18, 2007; 10.1124/mol.106.030759 [Abstract] [Full Text] [PDF]

Daniel J. Bridges, Matthew K. Gould, Barbara Nerima, Pascal Mäser, Richard J. S. Burchmore, and Harry P. de Koning: Loss of the High-Affinity Pentamidine Transporter Is Responsible for High Levels of Cross-Resistance between Arsenical and Diamidine Drugs in African Trypanosomes
Mol Pharmacol 2007 71: 1098-1108. Published online January 18, 2007; 10.1124/mol.106.031351 [Abstract] [Full Text] [PDF] [Data Supplement]

Yukun Yuan and William D. Atchison: Methylmercury-Induced Increase of Intracellular Ca²⁺ Increases Spontaneous Synaptic Current Frequency in Rat Cerebellar Slices
Mol Pharmacol 2007 71: 1109-1121. Published online January 23, 2007; 10.1124/mol.106.031286 [Abstract] [Full Text] [PDF]

Youwen Fang, Elaine Studer, Clint Mitchell, Steven Grant, William M. Pandak, Philip B. Hylemon, and Paul Dent: Conjugated Bile Acids Regulate Hepatocyte Glycogen Synthase Activity In Vitro and In Vivo via G ${alpha}$ _i Signaling
Mol Pharmacol 2007 71: 1122-1128. Published online January 2, 2007; 10.1124/mol.106.032060 [Abstract] [Full Text] [PDF]

Julie Y. H. Chan, Alice Y. W. Chang, Ling-Lin Wang, Chen-Chun Ou, and Samuel H. H. Chan: Protein Kinase C-Dependent Mitochondrial Translocation of Proapoptotic Protein Bax on Activation of Inducible Nitric-Oxide Synthase in Rostral Ventrolateral Medulla Mediates Cardiovascular Depression during Experimental Endotoxemia
Mol Pharmacol 2007 71: 1129-1139. Published online January 16, 2007; 10.1124/mol.106.031161 [Abstract] [Full Text] [PDF]

David Hamilton, Jian Hui Wu, and Gerald Batist: Structure-Based Identification of Novel Human ${gamma}$ -Glutamylcysteine Synthetase Inhibitors
Mol Pharmacol 2007 71: 1140-1147. Published online January 17, 2007; 10.1124/mol.106.024778 [Abstract] [Full Text] [PDF]

Guo-Chi Zhang, Li-Min Mao, Xian-Yu Liu, Nikhil K. Parelkar, Anish Arora, Lu Yang, Michelle Hains, Eugene E. Fibuch, and John Q. Wang: In Vivo Regulation of Homer1a Expression in the Striatum by Cocaine
Mol Pharmacol 2007 71: 1148-1158. Published online January 18, 2007; 10.1124/mol.106.028399 [Abstract] [Full Text] [PDF]

Chuan Chen, Xingguo Cheng, Matthew Z. Dieter, Yuji Tanaka, and Curtis D. Klaassen: Activation of cAMP-Dependent Signaling Pathway Induces Mouse Organic Anion Transporting Polypeptide 2 Expression
Mol Pharmacol 2007 71: 1159-1164. Published online January 23, 2007; 10.1124/mol.106.030841 [Abstract] [Full Text] [PDF]

Amin M. S. Abdul Majid, George Smythe, William A. Denny, and Laurence P. G. Wakelin: Structure of the d(CGCGAATTCGCG)₂ Complex of the Minor Groove Binding Alkylating Agent Alkamin Studied by Mass Spectrometry
Mol Pharmacol 2007 71: 1165-1178. Published online January 24, 2007; 10.1124/mol.106.030072 [Abstract] [Full Text] [PDF] [Data Supplement] [Erratum]

Takeharu Kawano, Peng Zhao, Christina V. Floreani, Yasuko Nakajima, Tohru Kozasa, and Shigehiro Nakajima: Interaction of G ${alpha}$ _q and Kir3, G Protein-Coupled Inwardly Rectifying Potassium Channels
Mol Pharmacol 2007 71: 1179-1184. Published online February 12, 2007; 10.1124/mol.106.032508 [Abstract] [Full Text] [PDF]

Cover Caption:

About the cover: Coexpression with Leu⁶⁵Ala,Val⁶⁶Ala,Leu¹⁶⁶AlaLeu¹⁶⁷Ala α_1b-adrenoceptor limits cell surface delivery of the wild-type α_1b-adrenoceptor but not the CXCR1 receptor. See the article by Lopez-Gimenez et al. on page 1015 of this issue.