Minireview:

Jiri Neuzil, Marco Tomasetti, Yan Zhao, Lan-Feng Dong, Marc Birringer, Xiu-Fang Wang, Pauline Low, Kun Wu, Brian A. Salvatore, and Steven J. Ralph

Vitamin E Analogs, a Novel Group of "Mitocans," as Anticancer Agents: The Importance of Being Redox-Silent
Mol Pharmacol 2007 71: 1185-1199. Published online January 12, 2007; 10.1124/mol.106.030122 [Abstract] [Full Text] [PDF]  

Perspectives:

Richard R. Neubig

Missing Links: Mechanisms of Protean Agonism
Mol Pharmacol 2007 71: 1200-1202. Published online February 9, 2007; 10.1124/mol.107.034926 [Abstract] [Full Text] [PDF] [Related Article]   

Sailen Barik

The Thrill Can Kill: Murder by Methylation
Mol Pharmacol 2007 71: 1203-1205. Published online February 15, 2007; 10.1124/mol.107.035196 [Abstract] [Full Text] [PDF] [Related Article]   

Randy D. Blakely and Louis J. DeFelice

All Aglow about Presynaptic Receptor Regulation of Neurotransmitter Transporters
Mol Pharmacol 2007 71: 1206-1208. Published online February 28, 2007; 10.1124/mol.107.035493 [Abstract] [Full Text] [PDF] [Related Article]   

Accelerated Communications:

Wende Niforatos, Xu-Feng Zhang, Marc R. Lake, Karl A. Walter, Torben Neelands, Thomas F. Holzman, Victoria E. Scott, Connie R. Faltynek, Robert B. Moreland, and Jun Chen

Activation of TRPA1 Channels by the Fatty Acid Amide Hydrolase Inhibitor 3'-Carbamoylbiphenyl-3-yl cyclohexylcarbamate (URB597)
Mol Pharmacol 2007 71: 1209-1216. Published online February 21, 2007; 10.1124/mol.106.033621 [Abstract] [Full Text] [PDF]  

Chika Koike, Rick Moore, and Masahiko Negishi

Extracellular Signal-Regulated Kinase Is an Endogenous Signal Retaining the Nuclear Constitutive Active/Androstane Receptor (CAR) in the Cytoplasm of Mouse Primary Hepatocytes
Mol Pharmacol 2007 71: 1217-1221. Published online February 21, 2007; 10.1124/mol.107.034538 [Abstract] [Full Text] [PDF]  

Articles:

Elizabeth A. Bolan, Bronwyn Kivell, Vanaja Jaligam, Murat Oz, Lankupalle D. Jayanthi, Yang Han, Namita Sen, Eneki Urizar, Ivone Gomes, Lakshmi A. Devi, Sammanda Ramamoorthy, Jonathan A. Javitch, Agustin Zapata, and Toni S. Shippenberg

D₂ Receptors Regulate Dopamine Transporter Function via an Extracellular Signal-Regulated Kinases 1 and 2-Dependent and Phosphoinositide 3 Kinase-Independent Mechanism
Mol Pharmacol 2007 71: 1222-1232. Published online January 31, 2007; 10.1124/mol.106.027763 [Abstract] [Full Text] [PDF]  

Elizabeth Alli, Jin-Ming Yang, James M. Ford, and William N. Hait

Reversal of Stathmin-Mediated Resistance to Paclitaxel and Vinblastine in Human Breast Carcinoma Cells
Mol Pharmacol 2007 71: 1233-1240. Published online February 1, 2007; 10.1124/mol.106.029702 [Abstract] [Full Text] [PDF]  

Godfrey Lisk, Seth Scott, Tsione Solomon, Ajay D. Pillai, and Sanjay A. Desai

Solute-Inhibitor Interactions in the Plasmodial Surface Anion Channel Reveal Complexities in the Transport Process
Mol Pharmacol 2007 71: 1241-1250. Published online February 7, 2007; 10.1124/mol.106.030734 [Abstract] [Full Text] [PDF]  

Michael Schupp, Joshua C. Curtin, Roy J. Kim, Andrew N. Billin, and Mitchell A. Lazar

A Widely Used Retinoic Acid Receptor Antagonist Induces Peroxisome Proliferator-Activated Receptor- Activity
Mol Pharmacol 2007 71: 1251-1257. Published online February 8, 2007; 10.1124/mol.106.033662 [Abstract] [Full Text] [PDF]  

Wenming Li, Jian Xue, Chunying Niu, Hongjun Fu, Colin S. C. Lam, Jialie Luo, Hugh H. N. Chan, Huaiguo Xue, Kelvin K. W. Kan, Nelson T. K. Lee, Chaoying Li, Yuanping Pang, Mingtao Li, Karl W. K. Tsim, Hualiang Jiang, Kaixian Chen, Xiaoyuan Li, and Yifan Han

Synergistic Neuroprotection by Bis(7)-tacrine via Concurrent Blockade of N-Methyl-D-aspartate Receptors and Neuronal Nitric-Oxide Synthase
Mol Pharmacol 2007 71: 1258-1267. Published online February 13, 2007; 10.1124/mol.106.029108 [Abstract] [Full Text] [PDF]  

Deguang Zhu, Robert I. Tate, Ralf Ruediger, Thomas E. Meigs, and Bradley M. Denker

Domains Necessary for G₁₂ Binding and Stimulation of Protein Phosphatase-2A (PP2A): Is G₁₂ a Novel Regulatory Subunit of PP2A?
Mol Pharmacol 2007 71: 1268-1276. Published online February 15, 2007; 10.1124/mol.106.033555 [Abstract] [Full Text] [PDF]  

Valerie B. Caraiscos, Robert P. Bonin, J. Glen Newell, Elzbieta Czerwinska, John F. Macdonald, and Beverley A. Orser

Insulin Increases the Potency of Glycine at Ionotropic Glycine Receptors
Mol Pharmacol 2007 71: 1277-1287. Published online February 16, 2007; 10.1124/mol.106.033563 [Abstract] [Full Text] [PDF]  

Dennis B. McKay, Cheng Chang, Tatiana F. González-Cestari, Susan B. McKay, Raed A. El-Hajj, Darrell L. Bryant, Michael X. Zhu, Peter W. Swaan, Kristjan M. Arason, Aravinda B. Pulipaka, Crina M. Orac, and Stephen C. Bergmeier

Analogs of Methyllycaconitine as Novel Noncompetitive Inhibitors of Nicotinic Receptors: Pharmacological Characterization, Computational Modeling, and Pharmacophore Development
Mol Pharmacol 2007 71: 1288-1297. Published online February 16, 2007; 10.1124/mol.106.033233 [Abstract] [Full Text] [PDF]  

Yuka Inaba, Keiko Yamamoto, Nobuko Yoshimoto, Manabu Matsunawa, Shigeyuki Uno, Sachiko Yamada, and Makoto Makishima

Vitamin D₃ Derivatives with Adamantane or Lactone Ring Side Chains are Cell Type-Selective Vitamin D Receptor Modulators
Mol Pharmacol 2007 71: 1298-1311. Published online February 26, 2007; 10.1124/mol.106.032318 [Abstract] [Full Text] [PDF]  

James T. McLaughlin, Jie Fu, and Robert L. Rosenberg

Agonist-Driven Conformational Changes in the Inner -Sheet of 7 Nicotinic Receptors
Mol Pharmacol 2007 71: 1312-1318. Published online February 26, 2007; 10.1124/mol.106.033092 [Abstract] [Full Text] [PDF]  

Haitao Zhang, Agus Darwanto, Thomas A. Linkhart, Lawrence C. Sowers, and Lubo Zhang

Maternal Cocaine Administration Causes an Epigenetic Modification of Protein Kinase C Gene Expression in Fetal Rat Heart
Mol Pharmacol 2007 71: 1319-1328. Published online January 3, 2007; 10.1124/mol.106.032011 [Abstract] [Full Text] [PDF]  

Mohammed A. Ayoub, Damien Maurel, Virginie Binet, Michel Fink, Laurent Prézeau, Hervé Ansanay, and Jean-Philippe Pin

Real-Time Analysis of Agonist-Induced Activation of Protease-Activated Receptor 1/G_i1 Protein Complex Measured by Bioluminescence Resonance Energy Transfer in Living Cells
Mol Pharmacol 2007 71: 1329-1340. Published online January 31, 2007; 10.1124/mol.106.030304 [Abstract] [Full Text] [PDF]  

Irina Shlaifer and Baruch I. Kanner

Conformationally Sensitive Reactivity to Permeant Sulfhydryl Reagents of Cysteine Residues Engineered into Helical Hairpin 1 of the Glutamate Transporter GLT-1
Mol Pharmacol 2007 71: 1341-1348. Published online February 1, 2007; 10.1124/mol.106.032607 [Abstract] [Full Text] [PDF]  

J. Robert Lane, Ben Powney, Alan Wise, Steven Rees, and Graeme Milligan

Protean Agonism at the Dopamine D₂ Receptor: (S)-3-(3-Hydroxyphenyl)-N-propylpiperidine Is an Agonist for Activation of G_o1 but an Antagonist/Inverse Agonist for G_i1,G_i2, and G_i3
Mol Pharmacol 2007 71: 1349-1359. Published online February 7, 2007; 10.1124/mol.106.032722 [Abstract] [Full Text] [PDF]  

Chantal N. St. Aubin, Jing-Jun Zhou, and Paul Linsdell

Identification of a Second Blocker Binding Site at the Cytoplasmic Mouth of the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Pore
Mol Pharmacol 2007 71: 1360-1368. Published online February 9, 2007; 10.1124/mol.106.031732 [Abstract] [Full Text] [PDF]  

Renata Ciccarelli, Iolanda D'Alimonte, Patrizia Ballerini, Mariagrazia D'Auro, Eleonora Nargi, Silvana Buccella, Patrizia Di Iorio, Valeria Bruno, Ferdinando Nicoletti, and Francesco Caciagli

Molecular Signalling Mediating the Protective Effect of A₁ Adenosine and mGlu3 Metabotropic Glutamate Receptor Activation against Apoptosis by Oxygen/Glucose Deprivation in Cultured Astrocytes
Mol Pharmacol 2007 71: 1369-1380. Published online February 9, 2007; 10.1124/mol.106.031617 [Abstract] [Full Text] [PDF]  

Wei Ju, Xia Wang, Honglian Shi, Wenshu Chen, Steven A. Belinsky, and Yong Lin

A Critical Role of Luteolin-Induced Reactive Oxygen Species in Blockage of Tumor Necrosis Factor-Activated Nuclear Factor-B Pathway and Sensitization of Apoptosis in Lung Cancer Cells
Mol Pharmacol 2007 71: 1381-1388. Published online February 12, 2007; 10.1124/mol.106.032185 [Abstract] [Full Text] [PDF] [Data Supplement]   

Yelin Chen, Yi Nong, Cyril Goudet, Kamondanai Hemstapat, Tomas de Paulis, Jean-Philippe Pin, and P. Jeffrey Conn

Interaction of Novel Positive Allosteric Modulators of Metabotropic Glutamate Receptor 5 with the Negative Allosteric Antagonist Site Is Required for Potentiation of Receptor Responses
Mol Pharmacol 2007 71: 1389-1398. Published online February 15, 2007; 10.1124/mol.106.032425 [Abstract] [Full Text] [PDF]  

Bryan Voss, Joseph N. McLaughlin, Michael Holinstat, Roy Zent, and Heidi E. Hamm

PAR1, but Not PAR4, Activates Human Platelets through a G_i/o/Phosphoinositide-3 Kinase Signaling Axis
Mol Pharmacol 2007 71: 1399-1406. Published online February 15, 2007; 10.1124/mol.106.033365 [Abstract] [Full Text] [PDF]  

Diego Rayes, Marina Flamini, Guillermina Hernando, and Cecilia Bouzat

Activation of Single Nicotinic Receptor Channels from Caenorhabditis elegans Muscle
Mol Pharmacol 2007 71: 1407-1415. Published online February 21, 2007; 10.1124/mol.106.033514 [Abstract] [Full Text] [PDF]  

Edita Navratilova, Sue Waite, Dagmar Stropova, Miriam C. Eaton, Isabel D. Alves, Victor J. Hruby, William R. Roeske, Henry I. Yamamura, and Eva V. Varga

Quantitative Evaluation of Human Opioid Receptor Desensitization Using the Operational Model of Drug Action
Mol Pharmacol 2007 71: 1416-1426. Published online February 22, 2007; 10.1124/mol.106.030023 [Abstract] [Full Text] [PDF]  

Riku Korhonen, Katrin Linker, Andrea Pautz, Ulrich Förstermann, Eeva Moilanen, and Hartmut Kleinert

Post-Transcriptional Regulation of Human Inducible Nitric-Oxide Synthase Expression by the Jun N-terminal Kinase
Mol Pharmacol 2007 71: 1427-1434. Published online February 22, 2007; 10.1124/mol.106.033449 [Abstract] [Full Text] [PDF]  

Vivian Wai Yan Lui, Amanda L. Boehm, Priya Koppikar, Rebecca J. Leeman, Daniel Johnson, Michelene Ogagan, Erin Childs, Maria Freilino, and Jennifer Rubin Grandis

Antiproliferative Mechanisms of a Transcription Factor Decoy Targeting Signal Transducer and Activator of Transcription (STAT) 3: The Role of STAT1
Mol Pharmacol 2007 71: 1435-1443. Published online February 26, 2007; 10.1124/mol.106.032284 [Abstract] [Full Text] [PDF]  

Errata:

Correction to "A Pair-Feeding Study Reveals That a Y5 Antagonist Causes Weight Loss in Diet-Induced Obese Mice by Modulating Food Intake and Energy Expenditure"
Mol Pharmacol 2007 71: 1444. [Full Text] [PDF]  

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