Mol Pharm -- Table of Contents (73 [3])

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March 2008; 73 (3)   [Index by Author] [Cover Caption]

       Perspectives

       Articles

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Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF) |

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Perspectives:

Mary Vore and Markos Leggas: Progesterone Acts via Progesterone Receptors A and B to Regulate Breast Cancer Resistance Protein Expression
Mol Pharmacol 2008 73: 613-615. Published online December 17, 2007; 10.1124/mol.107.044289 [Abstract] [Full Text] [PDF] [Related Article]

L. Keith Henry and Randy D. Blakely: Distinctions between Dopamine Transporter Antagonists Could be Just around the Bend
Mol Pharmacol 2008 73: 616-618. Published online December 21, 2007; 10.1124/mol.107.044586 [Abstract] [Full Text] [PDF] [Related Artcle]

Articles:

Jun-Ho Lee, Byung-Hwan Lee, Sun-Hye Choi, In-Soo Yoon, Mi Kyung Pyo, Tae-Joon Shin, Woo-Sung Choi, Yoongho Lim, Hyewhon Rhim, Kwang Hee Won, Yong Whan Lim, Han Choe, Dong-Hyun Kim, Yang In Kim, and Seung-Yeol Nah: Ginsenoside Rg₃ Inhibits Human Kv1.4 Channel Currents by Interacting with the Lys531 Residue
Mol Pharmacol 2008 73: 619-626. Published online October 24, 2007; 10.1124/mol.107.040360 [Abstract] [Full Text] [PDF]

Sufi Mary Thomas, Michelene Jeter Ogagan, Maria L. Freilino, Sandy Strychor, Dustin R. Walsh, William E. Gooding, Jennifer Rubin Grandis, and William C. Zamboni: Antitumor Mechanisms of Systemically Administered Epidermal Growth Factor Receptor Antisense Oligonucleotides in Combination with Docetaxel in Squamous Cell Carcinoma of the Head and Neck
Mol Pharmacol 2008 73: 627-638. Published online November 19, 2007; 10.1124/mol.107.041160 [Abstract] [Full Text] [PDF]

Earl Gordon, Irina M. Lozinskaya, Zuojun Lin, Simon F. Semus, Frank E. Blaney, Robert N. Willette, and Xiaoping Xu: 2-[2-(3,4-Dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic Acid (PD-307243) Causes Instantaneous Current through Human Ether-a-go-go-Related Gene Potassium Channels
Mol Pharmacol 2008 73: 639-651. Published online November 27, 2007; 10.1124/mol.107.041152 [Abstract] [Full Text] [PDF] [Data Supplement]

Silke Plaumann, Roland Blume, Svenja Börchers, Hans Jürgen Steinfelder, Willhart Knepel, and Elke Oetjen: Activation of the Dual-Leucine-Zipper-Bearing Kinase and Induction of β-Cell Apoptosis by the Immunosuppressive Drug Cyclosporin A
Mol Pharmacol 2008 73: 652-659. Published online November 27, 2007; 10.1124/mol.107.040782 [Abstract] [Full Text] [PDF] [Data Supplement]

Lu-Yi Lu, Yin-Cheng Hsieh, Ming-Yih Liu, Yih-Hung Lin, Chun-Jung Chen, and Yuh-Shyong Yang: Identification and Characterization of Two Amino Acids Critical for the Substrate Inhibition of Human Dehydroepiandrosterone Sulfotransferase (SULT2A1)
Mol Pharmacol 2008 73: 660-668. Published online November 27, 2007; 10.1124/mol.107.041038 [Abstract] [Full Text] [PDF]

Lauren A. Seiple, John H. Cardellina, II, Rhone Akee, and James T. Stivers: Potent Inhibition of Human Apurinic/Apyrimidinic Endonuclease 1 by Arylstibonic Acids
Mol Pharmacol 2008 73: 669-677. Published online November 27, 2007; 10.1124/mol.107.042622 [Abstract] [Full Text] [PDF] [Data Supplement]

Dyke P. McEwen, Qiuju Li, Sajida Jackson, Paul M. Jenkins, and Jeffrey R. Martens: Caveolin Regulates Kv1.5 Trafficking to Cholesterol-Rich Membrane Microdomains
Mol Pharmacol 2008 73: 678-685. Published online November 28, 2007; 10.1124/mol.107.042093 [Abstract] [Full Text] [PDF]

Hong Liang, Xing Wu, Jack C. Yalowich, and Brian B. Hasinoff: A Three-Dimensional Quantitative Structure-Activity Analysis of a New Class of Bisphenol Topoisomerase II ${alpha}$ Inhibitors
Mol Pharmacol 2008 73: 686-696. Published online November 28, 2007; 10.1124/mol.107.041624 [Abstract] [Full Text] [PDF] [Data Supplement]

Isabel Schwieger, Katja Lautz, Eberhard Krause, Walter Rosenthal, Burkhard Wiesner, and Ricardo Hermosilla: Derlin-1 and p97/Valosin-Containing Protein Mediate the Endoplasmic Reticulum-Associated Degradation of Human V2 Vasopressin Receptors
Mol Pharmacol 2008 73: 697-708. Published online November 29, 2007; 10.1124/mol.107.040931 [Abstract] [Full Text] [PDF] [Data Supplement]

Yvette Bren-Mattison, Amy M. Meyer, Vicki Van Putten, Howard Li, Katherine Kuhn, Robert Stearman, Mary Weiser-Evans, Robert A. Winn, Lynn E. Heasley, and Raphael A. Nemenoff: Antitumorigenic Effects of Peroxisome Proliferator-Activated Receptor- ${gamma}$ in Non-Small-Cell Lung Cancer Cells Are Mediated by Suppression of Cyclooxygenase-2 via Inhibition of Nuclear Factor- ${kappa}$ B
Mol Pharmacol 2008 73: 709-717. Published online November 30, 2007; 10.1124/mol.107.042002 [Abstract] [Full Text] [PDF] [Data Supplement]

Brianne S. Raccor, Andreas Vogt, Rachel P. Sikorski, Charitha Madiraju, Raghavan Balachandran, Kia Montgomery, Youseung Shin, Yoshikazu Fukui, Won-Hyuk Jung, Dennis P. Curran, and Billy W. Day: Cell-Based and Biochemical Structure-Activity Analyses of Analogs of the Microtubule Stabilizer Dictyostatin
Mol Pharmacol 2008 73: 718-726. Published online December 11, 2007; 10.1124/mol.107.042598 [Abstract] [Full Text] [PDF]

Luigi Formisano, Mariangela Saggese, Agnese Secondo, Rossana Sirabella, Pasquale Vito, Valeria Valsecchi, Pasquale Molinaro, Gianfranco Di Renzo, and Lucio Annunziato: The Two Isoforms of the Na⁺/Ca²⁺ Exchanger, NCX1 and NCX3, Constitute Novel Additional Targets for the Prosurvival Action of Akt/Protein Kinase B Pathway
Mol Pharmacol 2008 73: 727-737. Published online December 13, 2007; 10.1124/mol.107.042549 [Abstract] [Full Text] [PDF]

Juliann G. Kiang, Sandeep Krishnan, Xinyue Lu, and Yansong Li: Inhibition of Inducible Nitric-Oxide Synthase Protects Human T Cells from Hypoxia-Induced Apoptosis
Mol Pharmacol 2008 73: 738-747. Published online December 13, 2007; 10.1124/mol.107.041079 [Abstract] [Full Text] [PDF]

Benjamin Chanrion, Clotilde Mannoury la Cour, Sophie Gavarini, Mathieu Seimandi, Laurent Vincent, Jean-François Pujol, Joël Bockaert, Philippe Marin, and Mark J. Millan: Inverse Agonist and Neutral Antagonist Actions of Antidepressants at Recombinant and Native 5-Hydroxytryptamine_2C Receptors: Differential Modulation of Cell Surface Expression and Signal Transduction
Mol Pharmacol 2008 73: 748-757. Published online December 14, 2007; 10.1124/mol.107.041574 [Abstract] [Full Text] [PDF]

Ricardo De La Fuente, Wan Namkung, Aaron Mills, and A. S. Verkman: Small-Molecule Screen Identifies Inhibitors of a Human Intestinal Calcium-Activated Chloride Channel
Mol Pharmacol 2008 73: 758-768. Published online December 14, 2007; 10.1124/mol.107.043208 [Abstract] [Full Text] [PDF]

Patricia Monteiro, David Gilot, Eric Le Ferrec, Claudine Rauch, Dominique Lagadic-Gossmann, and Olivier Fardel: Dioxin-Mediated Up-Regulation of Aryl Hydrocarbon Receptor Target Genes Is Dependent on the Calcium/Calmodulin/CaMKI ${alpha}$ Pathway
Mol Pharmacol 2008 73: 769-777. Published online December 18, 2007; 10.1124/mol.107.043125 [Abstract] [Full Text] [PDF]

Elena A. Goncharova, Dmitry A. Goncharov, Amelia Chisolm, Matthew S. Spaits, Poay N. Lim, Gregory Cesarone, Irene Khavin, Omar Tliba, Yassine Amrani, Reynold A. Panettieri, Jr., and Vera P. Krymskaya: Interferon β Augments Tuberous Sclerosis Complex 2 (TSC2)-Dependent Inhibition of TSC2-Null ELT3 and Human Lymphangioleiomyomatosis-Derived Cell Proliferation
Mol Pharmacol 2008 73: 778-788. Published online December 19, 2007; 10.1124/mol.107.040824 [Abstract] [Full Text] [PDF]

Rama Kondru, Jun Zhang, Changhua Ji, Tara Mirzadegan, David Rotstein, Surya Sankuratri, and Marianna Dioszegi: Molecular Interactions of CCR5 with Major Classes of Small-Molecule Anti-HIV CCR5 Antagonists
Mol Pharmacol 2008 73: 789-800. Published online December 20, 2007; 10.1124/mol.107.042101 [Abstract] [Full Text] [PDF]

Metta Pinthong, Stefanie A. G. Black, Fabiola M. Ribeiro, Chumpol Pholpramool, Stephen S. G. Ferguson, and R. Jane Rylett: Activity and Subcellular Trafficking of the Sodium-Coupled Choline Transporter CHT Is Regulated Acutely by Peroxynitrite
Mol Pharmacol 2008 73: 801-812. Published online October 30, 2007; 10.1124/mol.107.040881 [Abstract] [Full Text] [PDF]

Claus J. Loland, Rajeev I. Desai, Mu-Fa Zou, Jianjing Cao, Peter Grundt, Klaus Gerstbrein, Harald H. Sitte, Amy Hauck Newman, Jonathan L. Katz, and Ulrik Gether: Relationship between Conformational Changes in the Dopamine Transporter and Cocaine-Like Subjective Effects of Uptake Inhibitors
Mol Pharmacol 2008 73: 813-823. Published online October 31, 2007; 10.1124/mol.107.039800 [Abstract] [Full Text] [PDF]

Yong-Wei Zhang, Zhi-Xiang Zhang, Ze-Hong Miao, and Jian Ding: The Telomeric Protein TRF2 Is Critical for the Protection of A549 Cells from Both Telomere Erosion and DNA Double-Strand Breaks Driven by Salvicine
Mol Pharmacol 2008 73: 824-832. Published online November 19, 2007; 10.1124/mol.107.039081 [Abstract] [Full Text] [PDF] [Erratum]

X. Xu, R. Sutak, and D. R. Richardson: Iron Chelation by Clinically Relevant Anthracyclines: Alteration in Expression of Iron-Regulated Genes and Atypical Changes in Intracellular Iron Distribution and Trafficking
Mol Pharmacol 2008 73: 833-844. Published online November 20, 2007; 10.1124/mol.107.041335 [Abstract] [Full Text] [PDF]

Honggang Wang, Eun-Woo Lee, Lin Zhou, Peter C. K. Leung, Douglas D. Ross, Jashvant D. Unadkat, and Qingcheng Mao: Progesterone Receptor (PR) Isoforms PRA and PRB Differentially Regulate Expression of the Breast Cancer Resistance Protein in Human Placental Choriocarcinoma BeWo Cells
Mol Pharmacol 2008 73: 845-854. Published online November 27, 2007; 10.1124/mol.107.041087 [Abstract] [Full Text] [PDF]

Glen Andrews, Carolyn Jones, and Keith A. Wreggett: An Intracellular Allosteric Site for a Specific Class of Antagonists of the CC Chemokine G Protein-Coupled Receptors CCR4 and CCR5
Mol Pharmacol 2008 73: 855-867. Published online November 27, 2007; 10.1124/mol.107.039321 [Abstract] [Full Text] [PDF]

Michael Shy, Sumita Chakrabarti, and Alan R. Gintzler: Plasticity of Adenylyl Cyclase-Related Signaling Sequelae after Long-Term Morphine Treatment
Mol Pharmacol 2008 73: 868-879. Published online November 28, 2007; 10.1124/mol.107.042184 [Abstract] [Full Text] [PDF]

John E. Baenziger, Stephen E. Ryan, Michael M. Goodreid, Ngoc Q. Vuong, Raymond M. Sturgeon, and Corrie J. B. daCosta: Lipid Composition Alters Drug Action at the Nicotinic Acetylcholine Receptor
Mol Pharmacol 2008 73: 880-890. Published online November 30, 2007; 10.1124/mol.107.039008 [Abstract] [Full Text] [PDF] [Data Supplement]

Taira Wada, Hong Soon Kang, Martin Angers, Haibiao Gong, Shikha Bhatia, Shaheen Khadem, Songrong Ren, Ewa Ellis, Stephen C. Strom, Anton M. Jetten, and Wen Xie: Identification of Oxysterol 7 ${alpha}$ -Hydroxylase (Cyp7b1) as a Novel Retinoid-Related Orphan Receptor ${alpha}$ (ROR ${alpha}$ ) (NR1F1) Target Gene and a Functional Cross-Talk between ROR ${alpha}$ and Liver X Receptor (NR1H3)
Mol Pharmacol 2008 73: 891-899. Published online November 30, 2007; 10.1124/mol.107.040741 [Abstract] [Full Text] [PDF]

Andria L. Del Tredici, Carsten B. Andersen, Erika A. Currier, Steven R. Ohrmund, Luke C. Fairbain, Birgitte W. Lund, Norman Nash, Roger Olsson, and Fabrice Piu: Identification of the First Synthetic Steroidogenic Factor 1 Inverse Agonists: Pharmacological Modulation of Steroidogenic Enzymes
Mol Pharmacol 2008 73: 900-908. Published online November 30, 2007; 10.1124/mol.107.040089 [Abstract] [Full Text] [PDF]

Yelin Chen, Cyril Goudet, Jean-Philippe Pin, and P. Jeffrey Conn: N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) Acts through a Novel Site as a Positive Allosteric Modulator of Group 1 Metabotropic Glutamate Receptors
Mol Pharmacol 2008 73: 909-918. Published online December 4, 2007; 10.1124/mol.107.040097 [Abstract] [Full Text] [PDF]

Rajesh R. Nair, Hector Avila, Xujun Ma, Zhengxin Wang, Michelle Lennartz, Bryant G. Darnay, Douglas D. Boyd, and Chunhong Yan: A Novel High-Throughput Screening System Identifies a Small Molecule Repressive for Matrix Metalloproteinase-9 Expression
Mol Pharmacol 2008 73: 919-929. Published online December 7, 2007; 10.1124/mol.107.042606 [Abstract] [Full Text] [PDF]

Radu Vasilcanu, Daiana Vasilcanu, Bita Sehat, Shucheng Yin, Ada Girnita, Magnus Axelson, and Leonard Girnita: Insulin-Like Growth Factor Type-I Receptor-Dependent Phosphorylation of Extracellular Signal-Regulated Kinase 1/2 but not Akt (Protein Kinase B) Can Be Induced by Picropodophyllin
Mol Pharmacol 2008 73: 930-939. Published online December 10, 2007; 10.1124/mol.107.040014 [Abstract] [Full Text] [PDF]

Ging Kuo Wang, Joanna Calderon, and Sho-Ya Wang: State- and Use-Dependent Block of Muscle Nav1.4 and Neuronal Nav1.7 Voltage-Gated Na⁺ Channel Isoforms by Ranolazine
Mol Pharmacol 2008 73: 940-948. Published online December 13, 2007; 10.1124/mol.107.041541 [Abstract] [Full Text] [PDF]

Lin Zhou, Suresh Babu Naraharisetti, Honggang Wang, Jashvant D. Unadkat, Mary F. Hebert, and Qingcheng Mao: The Breast Cancer Resistance Protein (Bcrp1/Abcg2) Limits Fetal Distribution of Glyburide in the Pregnant Mouse: An Obstetric-Fetal Pharmacology Research Unit Network and University of Washington Specialized Center of Research Study
Mol Pharmacol 2008 73: 949-959. Published online December 13, 2007; 10.1124/mol.107.041616 [Abstract] [Full Text] [PDF]

Nelson P. Barrera, Jill Betts, Haitao You, Robert M. Henderson, Ian L. Martin, Susan M. J. Dunn, and J. Michael Edwardson: Atomic Force Microscopy Reveals the Stoichiometry and Subunit Arrangement of the ${alpha}$ ₄β₃ ${delta}$ GABA_A Receptor
Mol Pharmacol 2008 73: 960-967. Published online December 13, 2007; 10.1124/mol.107.042481 [Abstract] [Full Text] [PDF]

Viola Tamasi, Kristy K. Michael Miller, Sharon L. Ripp, Ermin Vila, Thomas E. Geoghagen, and Russell A. Prough: Modulation of Receptor Phosphorylation Contributes to Activation of Peroxisome Proliferator Activated Receptor ${alpha}$ by Dehydroepiandrosterone and Other Peroxisome Proliferators
Mol Pharmacol 2008 73: 968-976. Published online December 13, 2007; 10.1124/mol.107.036780 [Abstract] [Full Text] [PDF]

A. D. Wickenden, J. L. Krajewski, B. London, P. K. Wagoner, W. A. Wilson, S. Clark, R. Roeloffs, G. McNaughton-Smith, and G. C. Rigdon: N-(6-Chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): A Novel, Selective KCNQ2/Q3 Potassium Channel Activator
Mol Pharmacol 2008 73: 977-986. Published online December 18, 2007; 10.1124/mol.107.043216 [Abstract] [Full Text] [PDF] [Data Supplement]

Makoto Yoshida, Yasuaki Kabe, Tadashi Wada, Akira Asai, and Hiroshi Handa: A New Mechanism of 6-((2-(Dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno(2,1-c)quinolin-7-one Dihydrochloride (TAS-103) Action Discovered by Target Screening with Drug-Immobilized Affinity Beads
Mol Pharmacol 2008 73: 987-994. Published online December 18, 2007; 10.1124/mol.107.043307 [Abstract] [Full Text] [PDF]

Reddy M. Pabbidi, De-Shou Cao, Arti Parihar, Mary E. Pauza, and Louis S. Premkumar: Direct Role of Streptozotocin in Inducing Thermal Hyperalgesia by Enhanced Expression of Transient Receptor Potential Vanilloid 1 in Sensory Neurons
Mol Pharmacol 2008 73: 995-1004. Published online December 18, 2007; 10.1124/mol.107.041707 [Abstract] [Full Text] [PDF]

Sung-Keum Seo, Hyeon-Ok Jin, Hyung-Chahn Lee, Sang-Hyeok Woo, Eun-Sung Kim, Doo-Hyun Yoo, Su-Jae Lee, Sungkwan An, Chang-Hun Rhee, Seok-Il Hong, Tae-Boo Choe, and In-Chul Park: Combined Effects of Sulindac and Suberoylanilide Hydroxamic Acid on Apoptosis Induction in Human Lung Cancer Cells
Mol Pharmacol 2008 73: 1005-1012. Published online December 21, 2007; 10.1124/mol.107.041293 [Abstract] [Full Text] [PDF]

Christine Börner, Andrea Bedini, Volker Höllt, and Jürgen Kraus: Analysis of Promoter Regions Regulating Basal and Interleukin-4-Inducible Expression of the Human CB1 Receptor Gene in T Lymphocytes
Mol Pharmacol 2008 73: 1013-1019. Published online December 21, 2007; 10.1124/mol.107.042945 [Abstract] [Full Text] [PDF]

Stanislav Sokolov, Richard L. Kraus, Todd Scheuer, and William A. Catterall: Inhibition of Sodium Channel Gating by Trapping the Domain II Voltage Sensor with Protoxin II
Mol Pharmacol 2008 73: 1020-1028. Published online December 21, 2007; 10.1124/mol.107.041046 [Abstract] [Full Text] [PDF]

Robert A. B. van Waterschoot, Antonius E. van Herwaarden, Jurjen S. Lagas, Rolf W. Sparidans, Els Wagenaar, Cornelia M. M. van der Kruijssen, Joyce A. Goldstein, Darryl C. Zeldin, Jos H. Beijnen, and Alfred H. Schinkel: Midazolam Metabolism in Cytochrome P450 3A Knockout Mice Can Be Attributed to Up-Regulated CYP2C Enzymes
Mol Pharmacol 2008 73: 1029-1036. Published online December 21, 2007; 10.1124/mol.107.043869 [Abstract] [Full Text] [PDF] [Data Supplement]

Cover Caption:

About the cover: Immunofluorescence images of HeLa cells treated with dictyostatin and analogs. See the article by Raccor et al. on page 718 of this issue.