Mol Pharm -- Table of Contents (73 [5])

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May 2008; 73 (5)   [Index by Author] [Cover Caption]

       Commentary

       Perspectives

       Accelerated Communications

       Articles

       Errata

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Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF) |

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Commentary:

Arun K. Shukla, Jin-Peng Sun, and Robert J. Lefkowitz: Crystallizing Thinking about the β2-Adrenergic Receptor
Mol Pharmacol 2008 73: 1333-1338. Published online January 31, 2008; 10.1124/mol.108.045849 [Abstract] [Full Text] [PDF]

Perspectives:

Thomas Del'guidice and Jean-Martin Beaulieu: Messing Up with Traffic: Different Effects of Antipsychotic Agents on Glutamate Receptor Complexes in Vivo
Mol Pharmacol 2008 73: 1339-1342. Published online February 26, 2008; 10.1124/mol.108.046540 [Abstract] [Full Text] [PDF] [Related Article]

Robert W. Robey, Alberto Lazarowski, and Susan E. Bates: P-Glycoprotein—a Clinical Target in Drug-Refractory Epilepsy?
Mol Pharmacol 2008 73: 1343-1346. Published online February 26, 2008; 10.1124/mol.108.046680 [Abstract] [Full Text] [PDF] [Related Article]

Accelerated Communications:

Giancarlo A. Biagini, Nicholas Fisher, Neil Berry, Paul A. Stocks, Brigitte Meunier, Dominic P. Williams, Richard Bonar-Law, Patrick G. Bray, Andrew Owen, Paul M. O'Neill, and Stephen A. Ward: Acridinediones: Selective and Potent Inhibitors of the Malaria Parasite Mitochondrial bc₁ Complex
Mol Pharmacol 2008 73: 1347-1355. Published online March 4, 2008; 10.1124/mol.108.045120 [Abstract] [Full Text] [PDF]

Douglas M. Yau, Nan Sethakorn, Sebastien Taurin, Steven Kregel, Nathan Sandbo, Blanca Camoretti-Mercado, Anne I. Sperling, and Nickolai O. Dulin: Regulation of Smad-Mediated Gene Transcription by RGS3
Mol Pharmacol 2008 73: 1356-1361. Published online February 20, 2008; 10.1124/mol.108.044990 [Abstract] [Full Text] [PDF]

Articles:

Aron Chakera, Ruth M. Seeber, Alison E. John, Karin A. Eidne, and David R. Greaves: The Duffy Antigen/Receptor for Chemokines Exists in an Oligomeric Form in Living Cells and Functionally Antagonizes CCR5 Signaling through Hetero-Oligomerization
Mol Pharmacol 2008 73: 1362-1370. Published online January 29, 2008; 10.1124/mol.107.040915 [Abstract] [Full Text] [PDF]

Sam R. J. Hoare, Beth A. Fleck, Raymond S. Gross, Paul D. Crowe, John P. Williams, and Dimitri E. Grigoriadis: Allosteric Ligands for the Corticotropin Releasing Factor Type 1 Receptor Modulate Conformational States Involved in Receptor Activation
Mol Pharmacol 2008 73: 1371-1380. Published online January 31, 2008; 10.1124/mol.107.042978 [Abstract] [Full Text] [PDF] [Data Supplement]

Ajaib Singh Paintlia, Manjeet Kaur Paintlia, Avtar Kaur Singh, and Inderjit Singh: Inhibition of Rho Family Functions by Lovastatin Promotes Myelin Repair in Ameliorating Experimental Autoimmune Encephalomyelitis
Mol Pharmacol 2008 73: 1381-1393. Published online January 31, 2008; 10.1124/mol.107.044230 [Abstract] [Full Text] [PDF]

Eric M. Grund, David Kagan, Cam Anh Tran, Andreas Zeitvogel, Anna Starzinski-Powitz, Selvaraj Nataraja, and Stephen S. Palmer: Tumor Necrosis Factor- ${alpha}$ Regulates Inflammatory and Mesenchymal Responses via Mitogen-Activated Protein Kinase Kinase, p38, and Nuclear Factor ${kappa}$ B in Human Endometriotic Epithelial Cells
Mol Pharmacol 2008 73: 1394-1404. Published online February 5, 2008; 10.1124/mol.107.042176 [Abstract] [Full Text] [PDF]

Tamás Kark, Zsolt Bagi, Erzsébet Lizanecz, Eniko T. Pásztor, Nóra Erdei, Ágnes Czikora, Zoltán Papp, István Édes, Róbert Pórszász, and Attila Tóth: Tissue-Specific Regulation of Microvascular Diameter: Opposite Functional Roles of Neuronal and Smooth Muscle Located Vanilloid Receptor-1
Mol Pharmacol 2008 73: 1405-1412. Published online February 6, 2008; 10.1124/mol.107.043323 [Abstract] [Full Text] [PDF]

Kuppuswami Girijashanker, Lei He, Manoocher Soleimani, Jodie M. Reed, Hong Li, Zhiwei Liu, Bin Wang, Timothy P. Dalton, and Daniel W. Nebert: Slc39a14 Gene Encodes ZIP14, A Metal/Bicarbonate Symporter: Similarities to the ZIP8 Transporter
Mol Pharmacol 2008 73: 1413-1423. Published online February 12, 2008; 10.1124/mol.107.043588 [Abstract] [Full Text] [PDF] [Erratum]

Ibolya E. András, GeunBae Rha, Wen Huang, SungYong Eum, Pierre-Olivier Couraud, Ignacio A. Romero, Bernhard Hennig, and Michal Toborek: Simvastatin Protects against Amyloid β and HIV-1 Tat-Induced Promoter Activities of Inflammatory Genes in Brain Endothelial Cells
Mol Pharmacol 2008 73: 1424-1433. Published online February 14, 2008; 10.1124/mol.107.042028 [Abstract] [Full Text] [PDF]

Andrea Biserni, Fabio Giannessi, Anna Floriana Sciarroni, Ferdinando Maria Milazzo, Adriana Maggi, and Paolo Ciana: In Vivo Imaging Reveals Selective Peroxisome Proliferator Activated Receptor Modulator Activity of the Synthetic Ligand 3-(1-(4-Chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl)-2,2-dimethylpropanoic acid (MK-886)
Mol Pharmacol 2008 73: 1434-1443. Published online February 21, 2008; 10.1124/mol.107.042689 [Abstract] [Full Text] [PDF]

Björn Bauer, Anika M. S. Hartz, Anton Pekcec, Kathrin Toellner, David S. Miller, and Heidrun Potschka: Seizure-Induced Up-Regulation of P-Glycoprotein at the Blood-Brain Barrier through Glutamate and Cyclooxygenase-2 Signaling
Mol Pharmacol 2008 73: 1444-1453. Published online December 19, 2007; 10.1124/mol.107.041210 [Abstract] [Full Text] [PDF]

Chiang-Wen Lee, Chih-Chung Lin, Shue-Fen Luo, Hui-Chun Lee, I.-Ta Lee, William C. Aird, Tsong-Long Hwang, and Chuen-Mao Yang: Tumor Necrosis Factor- ${alpha}$ Enhances Neutrophil Adhesiveness: Induction of Vascular Cell Adhesion Molecule-1 via Activation of Akt and CaM Kinase II and Modifications of Histone Acetyltransferase and Histone Deacetylase 4 in Human Tracheal Smooth Muscle Cells
Mol Pharmacol 2008 73: 1454-1464. Published online January 28, 2008; 10.1124/mol.107.038091 [Abstract] [Full Text] [PDF]

Yumei Fu, Shizhong Zheng, Shelly C. Lu, and Anping Chen: Epigallocatechin-3-gallate Inhibits Growth of Activated Hepatic Stellate Cells by Enhancing the Capacity of Glutathione Synthesis
Mol Pharmacol 2008 73: 1465-1473. Published online January 29, 2008; 10.1124/mol.107.040634 [Abstract] [Full Text] [PDF]

Soichiro Matsushima, Kazuya Maeda, Hisamitsu Hayashi, Yasuyuki Debori, Alfred H. Schinkel, John D. Schuetz, Hiroyuki Kusuhara, and Yuichi Sugiyama: Involvement of Multiple Efflux Transporters in Hepatic Disposition of Fexofenadine
Mol Pharmacol 2008 73: 1474-1483. Published online February 1, 2008; 10.1124/mol.107.041459 [Abstract] [Full Text] [PDF]

Fabio Fumagalli, Angelisa Frasca, Giorgio Racagni, and Marco Andrea Riva: Dynamic Regulation of Glutamatergic Postsynaptic Activity in Rat Prefrontal Cortex by Repeated Administration of Antipsychotic Drugs
Mol Pharmacol 2008 73: 1484-1490. Published online February 4, 2008; 10.1124/mol.107.043786 [Abstract] [Full Text] [PDF]

Prashanthi Javvadi, Andrew T. Segan, Stephen W. Tuttle, and Constantinos Koumenis: The Chemopreventive Agent Curcumin Is a Potent Radiosensitizer of Human Cervical Tumor Cells via Increased Reactive Oxygen Species Production and Overactivation of the Mitogen-Activated Protein Kinase Pathway
Mol Pharmacol 2008 73: 1491-1501. Published online February 5, 2008; 10.1124/mol.107.043554 [Abstract] [Full Text] [PDF]

Eun Ju Bae, Yoon Mee Yang, and Sang Geon Kim: Abrogation of Hyperosmotic Impairment of Insulin Signaling by a Novel Class of 1,2-Dithiole-3-thiones through the Inhibition of S6K1 Activation
Mol Pharmacol 2008 73: 1502-1512. Published online February 5, 2008; 10.1124/mol.107.044347 [Abstract] [Full Text] [PDF]

Günter Müller, Susanne Wied, Nicole Walz, and Christian Jung: Translocation of Glycosylphosphatidylinositol-Anchored Proteins from Plasma Membrane Microdomains to Lipid Droplets in Rat Adipocytes Is Induced by Palmitate, H₂O₂, and the Sulfonylurea Drug Glimepiride
Mol Pharmacol 2008 73: 1513-1529. Published online February 13, 2008; 10.1124/mol.107.043935 [Abstract] [Full Text] [PDF]

Hanan S. M. Farghaly, Ian S. Blagbrough, David A. Medina-Tato, and Malcolm L. Watson: Interleukin 13 Increases Contractility of Murine Tracheal Smooth Muscle by a Phosphoinositide 3-kinase p110 ${delta}$ -Dependent Mechanism
Mol Pharmacol 2008 73: 1530-1537. Published online February 14, 2008; 10.1124/mol.108.045419 [Abstract] [Full Text] [PDF]

M. J. Clark, J. J. Linderman, and J. R. Traynor: Endogenous Regulators of G Protein Signaling Differentially Modulate Full and Partial µ-Opioid Agonists at Adenylyl Cyclase as Predicted by a Collision Coupling Model
Mol Pharmacol 2008 73: 1538-1548. Published online February 19, 2008; 10.1124/mol.107.043547 [Abstract] [Full Text] [PDF]

Yasunari Takada, Gautam Sethi, Bokyung Sung, and Bharat B. Aggarwal: Flavopiridol Suppresses Tumor Necrosis Factor-Induced Activation of Activator Protein-1, c-Jun N-Terminal Kinase, p38 Mitogen-Activated Protein Kinase (MAPK), p44/p42 MAPK, and Akt, Inhibits Expression of Antiapoptotic Gene Products, and Enhances Apoptosis through Cytochrome c Release and Caspase Activation in Human Myeloid Cells
Mol Pharmacol 2008 73: 1549-1557. Published online February 20, 2008; 10.1124/mol.107.041350 [Abstract] [Full Text] [PDF]

Kyle J. Christian, Matti A. Lang, and Françoise Raffalli-Mathieu: Interaction of Heterogeneous Nuclear Ribonucleoprotein C1/C2 with a Novel cis-Regulatory Element within p53 mRNA as a Response to Cytostatic Drug Treatment
Mol Pharmacol 2008 73: 1558-1567. Published online February 22, 2008; 10.1124/mol.107.042507 [Abstract] [Full Text] [PDF]

Vérène Stierlé, Maria Duca, Ludovic Halby, Catherine Senamaud-Beaufort, Massimo L. Capobianco, Alain Laigle, Béatrice Jollès, and Paola B. Arimondo: Targeting MDR1 Gene: Synthesis and Cellular Study of Modified Daunomycin-Triplex-Forming Oligonucleotide Conjugates Able to Inhibit Gene Expression in Resistant Cell Lines
Mol Pharmacol 2008 73: 1568-1577. Published online February 25, 2008; 10.1124/mol.107.042010 [Abstract] [Full Text] [PDF] [Data Supplement]

Madanahally D. Kiran, Nallini Vijayarangan Adikesavan, Oscar Cirioni, Andrea Giacometti, Carmela Silvestri, Giorgio Scalise, Roberto Ghiselli, Vittorio Saba, Fiorenza Orlando, Menachem Shoham, and Naomi Balaban: Discovery of a Quorum-Sensing Inhibitor of Drug-Resistant Staphylococcal Infections by Structure-Based Virtual Screening
Mol Pharmacol 2008 73: 1578-1586. Published online February 26, 2008; 10.1124/mol.107.044164 [Abstract] [Full Text] [PDF]

Errata:

: Correction to "The Telomeric Protein TRF2 Is Critical for the Protection of A549 Cells from Both Telomere Erosion and DNA Double-Strand Breaks Driven by Salvicine"
Mol Pharmacol 2008 73: 1587. [Full Text] [PDF]

Cover Caption:

About the cover: SWISS-PROT homology model of P. falciparum cytochrome b in cartoon representation showing WR249685 docked at the Qo site region. See the article by Biagini et al. on page 1347 of this issue.