Mol Pharm -- Table of Contents (73 [6])

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June 2008; 73 (6)   [Index by Author] [Cover Caption]

       Perspectives

       Articles

       Errata

       Errata

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Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF) |

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

Perspectives:

Diego L. Varela, Tamara Hermosilla, and Gerald W. Zamponi: Making the T-Type Even Tinier: Corticotropin-Releasing Factor-Mediated Inhibition of Low-Voltage-Activated Calcium Channel Activity
Mol Pharmacol 2008 73: 1589-1591. Published online March 7, 2008; 10.1124/mol.108.046961 [Abstract] [Full Text] [PDF] [Related Article]

Jules C. Hancox and Andrew F. James: Refining Insights into High-Affinity Drug Binding to the Human Ether-à-go-go-Related Gene Potassium Channel
Mol Pharmacol 2008 73: 1592-1595. Published online April 1, 2008; 10.1124/mol.108.047563 [Abstract] [Full Text] [PDF] [Related Article]

Articles:

Jin Tao, Michael E. Hildebrand, Ping Liao, Mui Cheng Liang, Gregory Tan, Shengnan Li, Terrance P. Snutch, and Tuck Wah Soong: Activation of Corticotropin-Releasing Factor Receptor 1 Selectively Inhibits Ca_V3.2 T-Type Calcium Channels
Mol Pharmacol 2008 73: 1596-1609. Published online February 21, 2008; 10.1124/mol.107.043612 [Abstract] [Full Text] [PDF] [Data Supplement]

Giuseppe Nocentini, Salvatore Cuzzocrea, Tiziana Genovese, Rodolfo Bianchini, Emanuela Mazzon, Simona Ronchetti, Emanuela Esposito, Di Paola Rosanna, Placido Bramanti, and Carlo Riccardi: Glucocorticoid-Induced Tumor Necrosis Factor Receptor-Related (GITR)-Fc Fusion Protein Inhibits GITR Triggering and Protects from the Inflammatory Response after Spinal Cord Injury
Mol Pharmacol 2008 73: 1610-1621. Published online March 5, 2008; 10.1124/mol.107.044354 [Abstract] [Full Text] [PDF] [Data Supplement]

Caroline Pinet, Vincent Algalarrondo, Sylvie Sablayrolles, Bruno Le Grand, Christophe Pignier, Didier Cussac, Michel Perez, Stephane N. Hatem, and Alain Coulombe: Protease-Activated Receptor-1 Mediates Thrombin-Induced Persistent Sodium Current in Human Cardiomyocytes
Mol Pharmacol 2008 73: 1622-1631. Published online March 6, 2008; 10.1124/mol.107.043182 [Abstract] [Full Text] [PDF]

Amanda L. Boehm, Malabika Sen, Raja Seethala, William E. Gooding, Maria Freilino, Silvia Man Yan Wong, Shaomeng Wang, Daniel E. Johnson, and Jennifer Rubin Grandis: Combined Targeting of Epidermal Growth Factor Receptor, Signal Transducer and Activator of Transcription-3, and Bcl-X_L Enhances Antitumor Effects in Squamous Cell Carcinoma of the Head and Neck
Mol Pharmacol 2008 73: 1632-1642. Published online March 6, 2008; 10.1124/mol.107.044636 [Abstract] [Full Text] [PDF]

Toshihiko Myokai, Sunghi Ryu, Hirofumi Shimizu, and Shigetoshi Oiki: Topological Mapping of the Asymmetric Drug Binding to the Human Ether-à-go-go-Related Gene Product (HERG) Potassium Channel by Use of Tandem Dimers
Mol Pharmacol 2008 73: 1643-1651. Published online March 7, 2008; 10.1124/mol.107.042085 [Abstract] [Full Text] [PDF] [Data Supplement]

R. C. Zangar, N. Bollinger, S. Verma, N. J. Karin, and Y. Lu: The Nuclear Factor- ${kappa}$ B Pathway Regulates Cytochrome P450 3A4 Protein Stability
Mol Pharmacol 2008 73: 1652-1658. Published online March 11, 2008; 10.1124/mol.107.043976 [Abstract] [Full Text] [PDF]

Shiva Amiri, Masaru Shimomura, Ranjit Vijayan, Hisashi Nishiwaki, Miki Akamatsu, Kazuhiko Matsuda, Andrew K. Jones, Mark S. P. Sansom, Philip C. Biggin, and David B. Sattelle: A Role for Leu118 of Loop E in Agonist Binding to the ${alpha}$ 7 Nicotinic Acetylcholine Receptor
Mol Pharmacol 2008 73: 1659-1667. Published online March 13, 2008; 10.1124/mol.107.041590 [Abstract] [Full Text] [PDF]

Neil Kumar, Raffi Afeyan, Hyung-Do Kim, and Douglas A. Lauffenburger: Multipathway Model Enables Prediction of Kinase Inhibitor Cross-Talk Effects on Migration of Her2-Overexpressing Mammary Epithelial Cells
Mol Pharmacol 2008 73: 1668-1678. Published online March 18, 2008; 10.1124/mol.107.043794 [Abstract] [Full Text] [PDF] [Data Supplement]

Jordi M. Serra, Antonio Gutiérrez, Regina Alemany, María Navarro, Teresa Ros, Carlos Saus, Jordi Ginés, Antonia Sampol, Juan Carlos Amat, Lorenzo Serra-Moisés, Javier Martín, Antonio Galmés, Oliver Vögler, and Joan Besalduch: Inhibition of c-Myc Down-Regulation by Sustained Extracellular Signal-Regulated Kinase Activation Prevents the Antimetabolite Methotrexate- and Gemcitabine-Induced Differentiation in Non-Small-Cell Lung Cancer Cells
Mol Pharmacol 2008 73: 1679-1687. Published online March 19, 2008; 10.1124/mol.107.043372 [Abstract] [Full Text] [PDF]

Aurélia Ravni, David Vaudry, Matthew J. Gerdin, Maribeth V. Eiden, Anthony Falluel-Morel, Bruno J. Gonzalez, Hubert Vaudry, and Lee E. Eiden: A cAMP-Dependent, Protein Kinase A-Independent Signaling Pathway Mediating Neuritogenesis through Egr1 in PC12 Cells
Mol Pharmacol 2008 73: 1688-1708. Published online March 24, 2008; 10.1124/mol.107.044792 [Abstract] [Full Text] [PDF]

Xulin Xu, Maurizio Recanatini, Marinella Roberti, and Gea-Ny Tseng: Probing the Binding Sites and Mechanisms of Action of Two Human Ether-a-go-go-Related Gene Channel Activators, 1,3-bis-(2-Hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-Dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243)
Mol Pharmacol 2008 73: 1709-1721. Published online March 27, 2008; 10.1124/mol.108.045591 [Abstract] [Full Text] [PDF] [Data Supplement]

Narendra P. Singh, Mitzi Nagarkatti, and Prakash Nagarkatti: Primary Peripheral T Cells Become Susceptible to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin-Mediated Apoptosis in Vitro upon Activation and in the Presence of Dendritic Cells
Mol Pharmacol 2008 73: 1722-1735. Published online March 11, 2008; 10.1124/mol.107.043406 [Abstract] [Full Text] [PDF]

Pari Malherbe, Caterina Bissantz, Anne Marcuz, Claudia Kratzeisen, Marie-Thérèse Zenner, Joseph G. Wettstein, Hasane Ratni, Claus Riemer, and Will Spooren: Me-Talnetant and Osanetant Interact within Overlapping but Not Identical Binding Pockets in the Human Tachykinin Neurokinin 3 Receptor Transmembrane Domains
Mol Pharmacol 2008 73: 1736-1750. Published online February 28, 2008; 10.1124/mol.107.042754 [Abstract] [Full Text] [PDF]

Melissa A. Kramer, Allan E. Rettie, Mark J. Rieder, Erwin T. Cabacungan, and Ronald N. Hines: Novel CYP2C9 Promoter Variants and Assessment of Their Impact on Gene Expression
Mol Pharmacol 2008 73: 1751-1760. Published online February 29, 2008; 10.1124/mol.107.044149 [Abstract] [Full Text] [PDF] [Data Supplement]

Nilusha Ragunathan, Julien Dairou, Benjamin Pluvinage, Marta Martins, Emile Petit, Nathalie Janel, Jean-Marie Dupret, and Fernando Rodrigues-Lima: Identification of the Xenobiotic-Metabolizing Enzyme Arylamine N-Acetyltransferase 1 as a New Target of Cisplatin in Breast Cancer Cells: Molecular and Cellular Mechanisms of Inhibition
Mol Pharmacol 2008 73: 1761-1768. Published online February 29, 2008; 10.1124/mol.108.045328 [Abstract] [Full Text] [PDF]

Linling Cheng, Benjamin J. Stewart, Qiang You, Dennis R. Petersen, Joseph A. Ware, Joseph R. Piccotti, Thomas T. Kawabata, and Cynthia Ju: Covalent Binding of the Nitroso Metabolite of Sulfamethoxazole Is Important in Induction of Drug-Specific T-Cell Responses in Vivo
Mol Pharmacol 2008 73: 1769-1775. Published online March 11, 2008; 10.1124/mol.107.043273 [Abstract] [Full Text] [PDF]

Franck Madoux, Xiaolin Li, Peter Chase, Gina Zastrow, Michael D. Cameron, Juliana J. Conkright, Patrick R. Griffin, Scott Thacher, and Peter Hodder: Potent, Selective and Cell Penetrant Inhibitors of SF-1 by Functional Ultra-High-Throughput Screening
Mol Pharmacol 2008 73: 1776-1784. Published online March 11, 2008; 10.1124/mol.108.045963 [Abstract] [Full Text] [PDF]

Christoph J. Wruck, Mario E. Götz, Thomas Herdegen, Deike Varoga, Lars-Ove Brandenburg, and Thomas Pufe: Kavalactones Protect Neural Cells against Amyloid β Peptide-Induced Neurotoxicity via Extracellular Signal-Regulated Kinase 1/2-Dependent Nuclear Factor Erythroid 2-Related Factor 2 Activation
Mol Pharmacol 2008 73: 1785-1795. Published online March 11, 2008; 10.1124/mol.107.042499 [Abstract] [Full Text] [PDF]

Cecilia Gotti, Milena Moretti, Natalie M. Meinerz, Francesco Clementi, Annalisa Gaimarri, Allan C. Collins, and Michael J. Marks: Partial Deletion of the Nicotinic Cholinergic Receptor ${alpha}$ 4 or β2 Subunit Genes Changes the Acetylcholine Sensitivity of Receptor-Mediated ⁸⁶Rb⁺ Efflux in Cortex and Thalamus and Alters Relative Expression of ${alpha}$ 4 and β2 Subunits
Mol Pharmacol 2008 73: 1796-1807. Published online March 12, 2008; 10.1124/mol.108.045203 [Abstract] [Full Text] [PDF]

Laura H. Heitman, Kai Ye, Julia Oosterom, and Adriaan P. IJzerman: Amiloride Derivatives and a Nonpeptidic Antagonist Bind at Two Distinct Allosteric Sites in the Human Gonadotropin-Releasing Hormone Receptor
Mol Pharmacol 2008 73: 1808-1815. Published online March 14, 2008; 10.1124/mol.107.043521 [Abstract] [Full Text] [PDF]

Xiqun Chen, Lu Xu, Pheona Radcliffe, Baoyong Sun, and A. William Tank: Activation of Tyrosine Hydroxylase mRNA Translation by cAMP in Midbrain Dopaminergic Neurons
Mol Pharmacol 2008 73: 1816-1828. Published online March 18, 2008; 10.1124/mol.107.043968 [Abstract] [Full Text] [PDF]

Shin-Young Park, Chung-Hang Leung, and Yung-Chi Cheng: ATP Modulates Poly(ADP-Ribose) Polymerase-1-Facilitated Topoisomerase I-Linked DNA Religation in the Presence of Camptothecin
Mol Pharmacol 2008 73: 1829-1837. Published online March 18, 2008; 10.1124/mol.107.044438 [Abstract] [Full Text] [PDF]

Ruud Zwart, Anna L. Carbone, Mirko Moroni, Isabel Bermudez, Adrian J. Mogg, Elizabeth A. Folly, Lisa M. Broad, Andrew C. Williams, Deyi Zhang, Chunjin Ding, Beverly A. Heinz, and Emanuele Sher: Sazetidine-A Is a Potent and Selective Agonist at Native and Recombinant ${alpha}$ 4β2 Nicotinic Acetylcholine Receptors
Mol Pharmacol 2008 73: 1838-1843. Published online March 26, 2008; 10.1124/mol.108.045104 [Abstract] [Full Text] [PDF]

Nadine Dragin, Zhanquan Shi, Rajat Madan, Christopher L. Karp, Maureen A. Sartor, Chi Chen, Frank J. Gonzalez, and Daniel W. Nebert: Phenotype of the Cyp1a1/1a2/1b1(-/-) Triple-Knockout Mouse
Mol Pharmacol 2008 73: 1844-1856. Published online March 27, 2008; 10.1124/mol.108.045658 [Abstract] [Full Text] [PDF] [Data Supplement]

Nathalie Méthot, Daniel Guay, Joel Rubin, Diane Ethier, Karen Ortega, Simon Wong, Denis Normandin, Christian Beaulieu, T. Jagadeeswar Reddy, Denis Riendeau, and M. David Percival: In Vivo Inhibition of Serine Protease Processing Requires a High Fractional Inhibition of Cathepsin C
Mol Pharmacol 2008 73: 1857-1865. Published online March 6, 2008; 10.1124/mol.108.045682 [Abstract] [Full Text] [PDF]

Errata:

: Correction to Table of Contents (Volume 73, Number 4, April 2008)
Mol Pharmacol 2008 73: 1867. [Full Text] [PDF]

Errata:

: Correction to " ${alpha}$ 2 Subunit Specificity of Cyclothiazide Inhibition on Glycine Receptors"
Mol Pharmacol 2008 73: 1866. [Full Text] [PDF]

Cover Caption:

About the cover: SWISS-PROT homology model of P. falciparum cytochrome b in cartoon representation showing WR249685 docked at the Qo site region. See the article by Biagini et al. on page 1347 of this issue.