Perspective:

Terry P. Kenakin

Seven Transmembrane Receptors as Nature's Prototype Allosteric Protein: De-emphasizing the Geography of Binding
Mol Pharmacol 2008 74: 541-543. Published online June 26, 2008; 10.1124/mol.108.050062 [Abstract] [Full Text] [PDF] [Related Article]   

Accelerated Communication:

Pierre-Alexandre Vidi, Benjamin R. Chemel, Chang-Deng Hu, and Val J. Watts

Ligand-Dependent Oligomerization of Dopamine D₂ and Adenosine A_2A Receptors in Living Neuronal Cells
Mol Pharmacol 2008 74: 544-551. Published online June 4, 2008; 10.1124/mol.108.047472 [Abstract] [Full Text] [PDF] [Data Supplement]   

Articles:

Christophe D. Proulx, Brian J. Holleran, Antony A. Boucard, Emanuel Escher, Gaétan Guillemette, and Richard Leduc

Mutational Analysis of the Conserved Asp^2.50 and ERY Motif Reveals Signaling Bias of the Urotensin II Receptor
Mol Pharmacol 2008 74: 552-561. Published online May 28, 2008; 10.1124/mol.108.045054 [Abstract] [Full Text] [PDF]  

Laura Stanasila, Liliane Abuin, Julien Dey, and Susanna Cotecchia

Different Internalization Properties of the 1a- and 1b-Adrenergic Receptor Subtypes: The Potential Role of Receptor Interaction with β-Arrestins and AP50
Mol Pharmacol 2008 74: 562-573. Published online June 3, 2008; 10.1124/mol.107.043422 [Abstract] [Full Text] [PDF] [Data Supplement]   

Stewart M. Knoepp, Manpreet S. Chahal, Yuhuan Xie, Zhihong Zhang, Daniel J. Brauner, Mark A. Hallman, Stephanie A. Robinson, Shujie Han, Masaki Imai, Stephen Tomlinson, and Kathryn E. Meier

Effects of Active and Inactive Phospholipase D2 on Signal Transduction, Adhesion, Migration, Invasion, and Metastasis in EL4 Lymphoma Cells
Mol Pharmacol 2008 74: 574-584. Published online June 3, 2008; 10.1124/mol.107.040105 [Abstract] [Full Text] [PDF]  

Larry S. Barak, Ali Salahpour, Xiaodong Zhang, Bernard Masri, Tatyana D. Sotnikova, Amy J. Ramsey, Jonathan D. Violin, Robert J. Lefkowitz, Marc G. Caron, and Raul R. Gainetdinov

Pharmacological Characterization of Membrane-Expressed Human Trace Amine-Associated Receptor 1 (TAAR1) by a Bioluminescence Resonance Energy Transfer cAMP Biosensor
Mol Pharmacol 2008 74: 585-594. Published online June 4, 2008; 10.1124/mol.108.048884 [Abstract] [Full Text] [PDF]  

Rama Panford-Walsh, Wibke Singer, Lukas Rüttiger, Saida Hadjab, Justin Tan, Hyun-Soon Geisler, Ulrike Zimmermann, Iris Köpschall, Karin Rohbock, Anna Vieljans, Elmar Oestreicher, and Marlies Knipper

Midazolam Reverses Salicylate-Induced Changes in Brain-Derived Neurotrophic Factor and Arg3.1 Expression: Implications for Tinnitus Perception and Auditory Plasticity
Mol Pharmacol 2008 74: 595-604. Published online June 4, 2008; 10.1124/mol.108.046375 [Abstract] [Full Text] [PDF]  

Rosalind Mann, Mark J. Wigglesworth, and Dan Donnelly

Ligand-Receptor Interactions at the Parathyroid Hormone Receptors: Subtype Binding Selectivity Is Mediated via an Interaction between Residue 23 on the Ligand and Residue 41 on the Receptor
Mol Pharmacol 2008 74: 605-613. Published online June 6, 2008; 10.1124/mol.108.048017 [Abstract] [Full Text] [PDF]  

Gustav Akk, Ping Li, John Bracamontes, David E. Reichert, Douglas F. Covey, and Joe Henry Steinbach

Mutations of the GABA-A Receptor 1 Subunit M1 Domain Reveal Unexpected Complexity for Modulation by Neuroactive Steroids
Mol Pharmacol 2008 74: 614-627. Published online June 10, 2008; 10.1124/mol.108.048520 [Abstract] [Full Text] [PDF]  

Jianxi Liu, Thirumalini Vaithianathan, Kandiah Manivannan, Abby Parrill, and Alejandro M. Dopico

Ethanol Modulates BK_Ca Channels by Acting as an Adjuvant of Calcium
Mol Pharmacol 2008 74: 628-640. Published online June 13, 2008; 10.1124/mol.108.048694 [Abstract] [Full Text] [PDF] [Data Supplement]   

Lisa Mathiasen, Daniel M. Dupont, Anni Christensen, Grant E. Blouse, Jan K. Jensen, Ann Gils, Paul J. Declerck, Troels Wind, and Peter A. Andreasen

A Peptide Accelerating the Conversion of Plasminogen Activator Inhibitor-1 to an Inactive Latent State
Mol Pharmacol 2008 74: 641-653. Published online June 17, 2008; 10.1124/mol.108.046417 [Abstract] [Full Text] [PDF]  

Andrea L. Kasinski, Yuhong Du, Shala L. Thomas, Jing Zhao, Shi-Yong Sun, Fadlo R. Khuri, Cun-Yu Wang, Mamoru Shoji, Aiming Sun, James P. Snyder, Dennis Liotta, and Haian Fu

Inhibition of IB Kinase-Nuclear Factor-B Signaling Pathway by 3,5-Bis(2-flurobenzylidene)piperidin-4-one (EF24), a Novel Monoketone Analog of Curcumin
Mol Pharmacol 2008 74: 654-661. Published online June 24, 2008; 10.1124/mol.108.046201 [Abstract] [Full Text] [PDF] [Data Supplement]   

Sean Ekins, Vladyslav Kholodovych, Ni Ai, Michael Sinz, Joseph Gal, Lajos Gera, William J. Welsh, Kenneth Bachmann, and Sridhar Mani

Computational Discovery of Novel Low Micromolar Human Pregnane X Receptor Antagonists
Mol Pharmacol 2008 74: 662-672. Published online June 25, 2008; 10.1124/mol.108.049437 [Abstract] [Full Text] [PDF] [Data Supplement]   

Frederick S. Jones, Jie Jing, Anthony H. Stonehouse, Anthony Stevens, and Gerald M. Edelman

Caffeine Stimulates Cytochrome Oxidase Expression and Activity in the Striatum in a Sexually Dimorphic Manner
Mol Pharmacol 2008 74: 673-684. Published online June 26, 2008; 10.1124/mol.108.046888 [Abstract] [Full Text] [PDF]  

Dharini van der Hoeven, Tina C. Wan, and John A. Auchampach

Activation of the A₃ Adenosine Receptor Suppresses Superoxide Production and Chemotaxis of Mouse Bone Marrow Neutrophils
Mol Pharmacol 2008 74: 685-696. Published online June 26, 2008; 10.1124/mol.108.048066 [Abstract] [Full Text] [PDF]  

Helen H. W. Chen, Im-Sook Song, Anwar Hossain, Min-Koo Choi, Yoshiaki Yamane, Zheng D. Liang, Jia Lu, Lily Y.-H. Wu, Zahid H. Siddik, Leo W. J. Klomp, Niramol Savaraj, and Macus Tien Kuo

Elevated Glutathione Levels Confer Cellular Sensitization to Cisplatin Toxicity by Up-Regulation of Copper Transporter hCtr1
Mol Pharmacol 2008 74: 697-704. Published online June 3, 2008; 10.1124/mol.108.047969 [Abstract] [Full Text] [PDF]  

Im-Sook Song, Helen H. W. Chen, Isamu Aiba, Anwar Hossain, Zheng D. Liang, Leo W. J. Klomp, and Macus Tien Kuo

Transcription Factor Sp1 Plays an Important Role in the Regulation of Copper Homeostasis in Mammalian Cells
Mol Pharmacol 2008 74: 705-713. Published online May 15, 2008; 10.1124/mol.108.046771 [Abstract] [Full Text] [PDF]  

Huixia Zhang, Xiaohui Wu, Honggang Wang, Andrei M. Mikheev, Qingcheng Mao, and Jashvant D. Unadkat

Effect of Pregnancy on Cytochrome P450 3a and P-Glycoprotein Expression and Activity in the Mouse: Mechanisms, Tissue Specificity, and Time Course
Mol Pharmacol 2008 74: 714-723. Published online May 28, 2008; 10.1124/mol.107.043851 [Abstract] [Full Text] [PDF]  

Marina Gálvez-Peralta, Nga T. Dai, David A. Loegering, Karen S. Flatten, Stephanie L. Safgren, Jill M. Wagner, Matthew M. Ames, Larry M. Karnitz, and Scott H. Kaufmann

Overcoming S-Phase Checkpoint-Mediated Resistance: Sequence-Dependent Synergy of Gemcitabine and 7-Ethyl-10-hydroxycamptothecin (SN-38) in Human Carcinoma Cell Lines
Mol Pharmacol 2008 74: 724-735. Published online May 28, 2008; 10.1124/mol.108.047787 [Abstract] [Full Text] [PDF] [Data Supplement]   

Adebowale Adebiyi, Elizabeth M. McNally, and Jonathan H. Jaggar

Sulfonylurea Receptor-Dependent and -Independent Pathways Mediate Vasodilation Induced by ATP-Sensitive K⁺ Channel Openers
Mol Pharmacol 2008 74: 736-743. Published online May 29, 2008; 10.1124/mol.108.048165 [Abstract] [Full Text] [PDF]  

Michael H. Court, Suwagmani Hazarika, Soundararajan Krishnaswamy, Moshe Finel, and J. Andrew Williams

Novel Polymorphic Human UDP-glucuronosyltransferase 2A3: Cloning, Functional Characterization of Enzyme Variants, Comparative Tissue Expression, and Gene Induction
Mol Pharmacol 2008 74: 744-754. Published online June 3, 2008; 10.1124/mol.108.045500 [Abstract] [Full Text] [PDF]  

Ohad Mazor, Ofer Cohen, Chanoch Kronman, Lily Raveh, Dana Stein, Arie Ordentlich, and Avigdor Shafferman

Aging-Resistant Organophosphate Bioscavenger Based on Polyethylene Glycol-Conjugated F338A Human Acetylcholinesterase
Mol Pharmacol 2008 74: 755-763. Published online June 3, 2008; 10.1124/mol.108.047449 [Abstract] [Full Text] [PDF]  

Julius Militante, Bei-Wen Ma, Gustav Akk, and Joe Henry Steinbach

Activation and Block of the Adult Muscle-Type Nicotinic Receptor by Physostigmine: Single-Channel Studies
Mol Pharmacol 2008 74: 764-776. Published online June 3, 2008; 10.1124/mol.108.047134 [Abstract] [Full Text] [PDF]  

Isabelle Bar, Pieter-Jan Guns, Jessica Metallo, Dorothée Cammarata, Françoise Wilkin, Jean-Marie Boeynams, Hidde Bult, and Bernard Robaye

Knockout Mice Reveal a Role for P2Y₆ Receptor in Macrophages, Endothelial Cells, and Vascular Smooth Muscle Cells
Mol Pharmacol 2008 74: 777-784. Published online June 3, 2008; 10.1124/mol.108.046904 [Abstract] [Full Text] [PDF]  

Louis-Philippe Bernier, Ariel R. Ase, Xinkang Tong, Edith Hamel, Dominique Blais, Qi Zhao, Diomedes E. Logothetis, and Philippe Séguéla

Direct Modulation of P2X₁ Receptor-Channels by the Lipid Phosphatidylinositol 4,5-Bisphosphate
Mol Pharmacol 2008 74: 785-792. Published online June 3, 2008; 10.1124/mol.108.047019 [Abstract] [Full Text] [PDF]  

Yi-He Ling, Ruoping Lin, and Roman Perez-Soler

Erlotinib Induces Mitochondrial-Mediated Apoptosis in Human H3255 Non-Small-Cell Lung Cancer Cells with Epidermal Growth Factor Receptor^L858R Mutation through Mitochondrial Oxidative Phosphorylation-Dependent Activation of BAX and BAK
Mol Pharmacol 2008 74: 793-806. Published online June 4, 2008; 10.1124/mol.107.044396 [Abstract] [Full Text] [PDF] [Data Supplement]   

Aditi Pandya Martin, Anna Miller, Luni Emad, Mohammed Rahmani, Teneille Walker, Clint Mitchell, Michael P. Hagan, Margaret A. Park, Adly Yacoub, Paul B. Fisher, Steven Grant, and Paul Dent

Lapatinib Resistance in HCT116 Cells Is Mediated by Elevated MCL-1 Expression and Decreased BAK Activation and Not by ERBB Receptor Kinase Mutation
Mol Pharmacol 2008 74: 807-822. Published online June 10, 2008; 10.1124/mol.108.047365 [Abstract] [Full Text] [PDF] [Data Supplement]   

Isamu Aiba, Anwar Hossain, and Macus Tien Kuo

Elevated GSH Level Increases Cadmium Resistance through Down-Regulation of Sp1-Dependent Expression of the Cadmium Transporter ZIP8
Mol Pharmacol 2008 74: 823-833. Published online June 12, 2008; 10.1124/mol.108.046862 [Abstract] [Full Text] [PDF]  

Dar'ya S. Redka, Luca F. Pisterzi, and James W. Wells

Binding of Orthosteric Ligands to the Allosteric Site of the M₂ Muscarinic Cholinergic Receptor
Mol Pharmacol 2008 74: 834-843. Published online June 13, 2008; 10.1124/mol.108.048074 [Abstract] [Full Text] [PDF]  

Xiomara A. Perez, Tanuja Bordia, J. Michael McIntosh, Sharon R. Grady, and Maryka Quik

Long-Term Nicotine Treatment Differentially Regulates Striatal 64β2^* and 6(Non4)β2^* nAChR Expression and Function
Mol Pharmacol 2008 74: 844-853. Published online June 26, 2008; 10.1124/mol.108.048843 [Abstract] [Full Text] [PDF]  

Rongbao Zhao, Andong Qiu, Eugenia Tsai, Michaela Jansen, Myles H. Akabas, and I. David Goldman

The Proton-Coupled Folate Transporter: Impact on Pemetrexed Transport and on Antifolates Activities Compared with the Reduced Folate Carrier
Mol Pharmacol 2008 74: 854-862. Published online June 4, 2008; 10.1124/mol.108.045443 [Abstract] [Full Text] [PDF]  

Sheryl A. Flanagan, Christina M. Krokosky, Sudha Mannava, Mikhail A. Nikiforov, and Donna S. Shewach

MLH1 Deficiency Enhances Radiosensitization with 5-Fluorodeoxyuridine by Increasing DNA Mismatches
Mol Pharmacol 2008 74: 863-871. Published online June 5, 2008; 10.1124/mol.107.043349 [Abstract] [Full Text] [PDF]  

Yun Ge, Jung S. Byun, Paola De Luca, Geraldine Gueron, Idalia M. Yabe, Sara G. Sadiq-Ali, William D. Figg, Jesse Quintero, Cynthia M. Haggerty, Quentin Q. Li, Adriana De Siervi, and Kevin Gardner

Combinatorial Antileukemic Disruption of Oxidative Homeostasis and Mitochondrial Stability by the Redox Reactive Thalidomide 2-(2,4-Difluoro-phenyl)-4,5,6,7-tetrafluoro-1H-isoindole-1,3(2H)-dione (CPS49) and Flavopiridol
Mol Pharmacol 2008 74: 872-883. Published online June 12, 2008; 10.1124/mol.107.040808 [Abstract] [Full Text] [PDF]  

Federica Falà, William L. Blalock, Pier Luigi Tazzari, Alessandra Cappellini, Francesca Chiarini, Giovanni Martinelli, Agostino Tafuri, James A. McCubrey, Lucio Cocco, and Alberto M. Martelli

Proapoptotic Activity and Chemosensitizing Effect of the Novel Akt Inhibitor (2S)-1-(1H-Indol-3-yl)-3-[5-(3-methyl-2H-indazol-5-yl)pyridin-3-yl]oxypropan2-amine (A443654) in T-Cell Acute Lymphoblastic Leukemia
Mol Pharmacol 2008 74: 884-895. Published online June 24, 2008; 10.1124/mol.108.047639 [Abstract] [Full Text] [PDF]  

David Marsolais, Bumsuk Hahm, Kurt H. Edelmann, Kevin B. Walsh, Miguel Guerrero, Yasuko Hatta, Yoshihiro Kawaoka, Edward Roberts, Michael B. A. Oldstone, and Hugh Rosen

Local Not Systemic Modulation of Dendritic Cell S1P Receptors in Lung Blunts Virus-Specific Immune Responses to Influenza
Mol Pharmacol 2008 74: 896-903. Published online June 24, 2008; 10.1124/mol.108.048769 [Abstract] [Full Text] [PDF] [Data Supplement]   

Patrice M. Mich and William A. Horne

Alternative Splicing of the Ca²⁺ Channel β4 Subunit Confers Specificity for Gabapentin Inhibition of Ca_v2.1 Trafficking
Mol Pharmacol 2008 74: 904-912. Published online June 26, 2008; 10.1124/mol.108.045153 [Abstract] [Full Text] [PDF]  

Sailesh Surapureddi, Ritu Rana, Janardan K. Reddy, and Joyce A. Goldstein

Nuclear Receptor Coactivator 6 Mediates the Synergistic Activation of Human Cytochrome P-450 2C9 by the Constitutive Androstane Receptor and Hepatic Nuclear Factor-4
Mol Pharmacol 2008 74: 913-923. Published online June 13, 2008; 10.1124/mol.108.048983 [Abstract] [Full Text] [PDF]  

Errata:

Correction to "Fluvastatin Synergistically Improves the Antiproliferative Effect of Everolimus on Rat Smooth Muscle Cells by Altering p27^Kip1/Cyclin E Expression"
Mol Pharmacol 2008 74: 924. [Full Text] [PDF]  

Correction to "Slc39a14 Gene Encodes ZIP14, A Metal/Bicarbonate Symporter: Similarities to the ZIP8 Transporter"
Mol Pharmacol 2008 74: 924. [Full Text] [PDF]  

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